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Cat. No. |
BID-1437H |
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Product Overview |
Recombinant full-length human BID was expressed by
baculovirus in Sf9 insect cells using an N-terminal GST tag.
MW = 52kDa. |
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Description |
BID is a BH3 interacting death domain that heterodimerizes
with either agonist BAX or antagonist BCL2. BID is a member
of the BCL-2 family of cell death regulators and is a
mediator of mitochondrial damage induced by caspase-8
(CASP8). BID initiates apoptosis by binding to regulatory
sites on prosurvival BCL2 proteins to directly neutralize
their function. Multiple alternatively spliced transcript
variants of BID have been found, but the full-length nature
of some variants has not been defined. BID together with
Cathepsins play an important role in the actions of
Camptothecin on breast cancer cells. |
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Source |
Sf9 insect cells using baculovirus. |
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Sequence |
Full-length. |
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Applications |
Western Blot. |
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Storage And Stability |
Store product at -70℃. For optimal storage, aliquot target
into smaller quantities after centrifugation and store at
recommended temperature. For most favorable performance,
avoid repeated handling and multiple freeze/thaw cycles. |
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Gene Information
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Gene Name |
BID BH3 interacting domain death agonist [ Homo sapiens ] |
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Synonyms |
BID; BH3 interacting domain death agonist; FP497; MGC15319;
MGC42355; p22 BID |
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GeneID |
637 |
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mRNA Refseq |
NM_00119 |
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Protein Refseq |
NP_001187 |
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MIM |
601997 |
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UniProt ID |
P55957 |
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Chromosome Location |
22q11.2 |
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Pathway |
Alzheimer"s disease; Amyotrophic lateral sclerosis (ALS);
Apoptosis; Natural killer cell mediated cytotoxicity;
Pathways in cancer; p53 signaling pathway; Apoptosis |
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Function |
death receptor binding; protein binding |
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