Catalog # or name ...
Recombinant full-length human BID was expressed by
baculovirus in Sf9 insect cells using an N-terminal GST tag.
MW = 52kDa.
BID is a BH3 interacting death domain that heterodimerizes
with either agonist BAX or antagonist BCL2. BID is a member
of the BCL-2 family of cell death regulators and is a
mediator of mitochondrial damage induced by caspase-8
(CASP8). BID initiates apoptosis by binding to regulatory
sites on prosurvival BCL2 proteins to directly neutralize
their function. Multiple alternatively spliced transcript
variants of BID have been found, but the full-length nature
of some variants has not been defined. BID together with
Cathepsins play an important role in the actions of
Camptothecin on breast cancer cells.
Sf9 insect cells using baculovirus.
Storage And Stability
Store product at -70℃. For optimal storage, aliquot target
into smaller quantities after centrifugation and store at
recommended temperature. For most favorable performance,
avoid repeated handling and multiple freeze/thaw cycles.
BID BH3 interacting domain death agonist [ Homo sapiens ]
BID; BH3 interacting domain death agonist; FP497; MGC15319;
MGC42355; p22 BID
Alzheimer"s disease; Amyotrophic lateral sclerosis (ALS);
Apoptosis; Natural killer cell mediated cytotoxicity;
Pathways in cancer; p53 signaling pathway; Apoptosis
death receptor binding; protein binding
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