Recombinant Human DPP4, His-tagged
Cat.No. : | DPP4-27255TH |
Product Overview : | Recombinant fragment corresponding to amino acids 29-766 of Human CD26 with C terminal His tag expressed in a Baculovirus infected Sf9 cell expression system, 89 kDa. |
- Specification
- Gene Information
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Description : | The protein encoded by this gene is identical to adenosine deaminase complexing protein-2, and to the T-cell activation antigen CD26. It is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. |
Conjugation : | HIS |
Tissue specificity : | Expressed specifically in lymphatic vessels but not in blood vessels in the skin, small intestine, esophagus, ovary, breast and prostate glands. Not detected in lymphatic vessels in the lung, kidney, uterus, liver and stomach (at protein level). Expressed |
Biological activity : | Specific Activity: 4630 pmol/min/μg. |
Form : | Liquid |
Purity : | >95% by SDS-PAGE |
Storage buffer : | Preservative: NoneConstituents: 50% Glycerol, 0.05% Tween 20, 3mM DTT, 25mM Tris HCl, 100mM Sodium chloride, pH 8.0 |
Storage : | Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles. |
Sequence Similarities : | Belongs to the peptidase S9B family. DPPIV subfamily. |
Gene Name : | DPP4 dipeptidyl-peptidase 4 [ Homo sapiens ] |
Official Symbol : | DPP4 |
Synonyms : | DPP4; dipeptidyl-peptidase 4; ADCP2, adenosine deaminase complexing protein 2 , CD26, dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2); dipeptidyl peptidase 4; DPPIV; |
Gene ID : | 1803 |
mRNA Refseq : | NM_001935 |
Protein Refseq : | NP_001926 |
MIM : | 102720 |
Uniprot ID : | P27487 |
Chromosome Location : | 2q23-qter |
Pathway : | Incretin Synthesis, Secretion, and Inactivation, organism-specific biosystem; Integration of energy metabolism, organism-specific biosystem; Metabolism, organism-specific biosystem; Protein digestion and absorption, organism-specific biosystem; Protein digestion and absorption, conserved biosystem; |
Function : | aminopeptidase activity; collagen binding; dipeptidyl-peptidase activity; peptidase activity; peptide binding; |
Products Types
◆ Recombinant Protein | ||
DPP4-4063H | Recombinant Human DPP4 protein(Asn29-Pro766), C-His-tagged | +Inquiry |
DPP4-783H | Recombinant Human DPP4 Protein, His (Fc)-Avi-tagged | +Inquiry |
DPP4-2844H | Recombinant Human DPP4 Protein | +Inquiry |
DPP4-203H | Recombinant Human DPP4 Protein, Fc-tagged | +Inquiry |
DPP4-040H | Recombinant Human DPP4 Protein, His-tagged | +Inquiry |
◆ Native Protein | ||
DPP4-197H | Native Human Dipeptidyl Peptidase IV | +Inquiry |
DPP4-31H | Active Native Human DPP4 | +Inquiry |
◆ Lysates | ||
DPP4-2979HCL | Recombinant Human DPP4 cell lysate | +Inquiry |
DPP4-733CCL | Recombinant Cynomolgus DPP4 cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-0314 | DPP4 Activity Fluorometric Assay Kit | +Inquiry |
Kit-0315 | DPP4 Inhibitor Screening Kit | +Inquiry |
Kit-0313 | DPP IV Immunocapture Activity Assay Kit | +Inquiry |
Kit-0312 | Dipeptidyl peptidase IV Inhibitor Screening Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionDPP4 plays a crucial role in glucose homeostasis by cleaving incretin hormones. In diabetes, inhibiting DPP4 can enhance the action of these hormones, promoting insulin release and lowering blood sugar levels.
Common side effects of DPP4 inhibitors include respiratory and urinary tract infections, headache, and nasopharyngitis. However, they are generally well-tolerated.
Inhibitors of DPP4 are used in the treatment of type 2 diabetes to improve glycemic control. They work by prolonging the activity of incretin hormones, such as GLP-1, which stimulate insulin secretion.
DPP4 inhibitors are often used as monotherapy or in combination with other antidiabetic medications to achieve optimal glycemic control.
DPP4 inhibitors work by enhancing the effects of incretin hormones, while other diabetes medications may act on insulin sensitivity, insulin release, or glucose absorption.
Customer Reviews (3)
Write a reviewIts purity and efficacy make it an ideal choice for precise and accurate analysis, allowing me to generate reliable results.
By incorporating the DPP4 Protein into their studies, scientists can confidently conduct their research, ushering in groundbreaking discoveries and novel insights within their respective domains.
Its exceptional purity and functionality make it an ideal choice for accurate and precise analysis, ensuring reliable and reproducible results.
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