Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Human ERG, GST-tagged

Cat.No. : ERG-28690TH
Product Overview : Recombinant Human ERG(1 a.a. - 100 a.a.), fused with GST-tag at N-terminal, was expressed in wheat germ.
  • Specification
  • Gene Information
  • Related Products
Description : This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
Source : Wheat germ
Species : Human
Tag : GST
Molecular Mass : 36.74 kDa
AA Sequence : MASTIKEALSVVSEDQSLFECAYGT PHLAKTEMTASSSSDYGQTSKMSPR VPQQDWLSQPPARVTIKMECNPSQV NGSRNSPDECSVAKGGKMVGSPDTV
Applications : ELISA; WB-Re; AP; Array
Storage : Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : ERG v-ets avian erythroblastosis virus E26 oncogene homolog [ Homo sapiens (human) ]
Official Symbol : ERG
Synonyms : ERG; p55; erg-3; v-ets avian erythroblastosis virus E26 oncogene homolog; transcriptional regulator ERG; ets-related; TMPRSS2/ERG fusion; v-ets erythroblastosis virus E26 oncogene like; v-ets erythroblastosis virus E26 oncogene homolog; v-ets avian erythroblastosis virus E26 oncogene related; transcriptional regulator ERG (transforming protein ERG)
Gene ID : 2078
mRNA Refseq : NM_182918
Protein Refseq : NP_891548
MIM : 165080
UniProt ID : P11308
Chromosome Location : 21q22.3
Pathway : Prostate Cancer; Transcriptional misregulation in cancer
Function : DNA binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (0)

Ask a question

Customer Reviews (0)

Write a review

Ask a Question for All ERG Products

Required fields are marked with *

My Review for All ERG Products

Required fields are marked with *

0

Inquiry Basket

cartIcon
logo

FOLLOW US

Terms and Conditions        Privacy Policy

Copyright © 2024 Creative BioMart. All Rights Reserved.

Contact Us

  • /

Stay Updated on the Latest Bioscience Trends