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Cat.No.
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PRKD2-30220TH
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Product Overview
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Recombinant full length Protein Kinase D2 protein (Human), was expressed by baculovirus in Sf9 insect cells using a N-terminal tag, MW 130 kDa.
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Description
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The protein encoded by this gene belongs to the protein kinase D (PKD) family of serine/threonine protein kinases. This kinase can be activated by phorbol esters as well as by gastrin via the cholecystokinin B receptor (CCKBR) in gastric cancer cells. It can bind to diacylglycerol (DAG) in the trans-Golgi network (TGN) and may regulate basolateral membrane protein exit from TGN. Alternative splicing results in multiple transcript variants encoding different isoforms.
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Tissue specificity
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Widely expressed.
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Form
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Liquid
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Storage buffer
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Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
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Storage
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Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
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Sequence Similarities
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Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.Contains 1 PH domain.Contains 2 phorbol-ester/DAG-type zinc fingers.Contains 1 protein kinase domain.
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Antigen Gene Information
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Gene Name
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PRKD2 protein kinase D2 [ Homo sapiens ]
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Official Symbol
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PRKD2
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Synonyms
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PRKD2; protein kinase D2; serine/threonine-protein kinase D2; DKFZP586E0820; HSPC187; PKD2;
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GeneID
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25865
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mRNA Refseq
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NM_001079880
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Protein Refseq
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NP_001073349
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MIM
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607074
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Uniprot ID
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Q9BZL6
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Chromosome Location
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19q13.2
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Pathway
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T Cell Receptor Signaling Pathway, organism-specific biosystem;
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Function
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ATP binding; metal ion binding; nucleotide binding; protein kinase C activity; protein kinase activity;
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Download Datasheet:
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