Recombinant Mouse Interferon Gamma Receptor 1, Fc-tagged
Cat.No. : | Ifngr1-1748M |
Product Overview : | Recombinant Mouse Ifngr1 encoding the extracellular domain was fused to the carboxy-terminal Fc region of human IgG1 via a linker peptide, inserted into a suitable mammalian expression vector and expressed inNSO cells. |
- Specification
- Gene Information
- Related Products
Cat. No. : | Ifngr1-1748M |
Description : | IFN-γ receptor ligand-binding chain (IFNγR1) or IFN-γ R α chain, also known CDw119, is member of the class II cytokine receptor family. The IFN-γ receptor is a complex of a high affinity IFN-γ-binding chain (aka, IFN-γ R α chain) and a second accessory protein required for signal transduction known as IFN-γ R β chain. Binding of IFN-γ induces receptor dimerization and internalization. Signal transduction involves Jak1 and Jak2 protein kinases and involves STAT1 activation. The IFN-γ receptor is expressed at moderate levels on virtually every cell with the exception of erythrocytes. |
Molecular Weight : | The predicted molecular weight of Recombinant Mouse IFN-γ R1 is Mr 52 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 70-90 kDa. |
Source : | Mammalian cells |
State Of Matter : | Lyophilized. |
Purity : | >95% by SDS Page and analyzed by silver stain. |
Endotoxin : | <1.0 EU/µg as determined by the LAL method. |
Biological Activity : | The biological activity of Mouse IFN-γ R1 was determined by its ability to inhibit rmIFN-γ mediated protection of mouse L929 cells viral lysis. The expected ED50 is typically 0.4 - 2 μg/mL in the presence of 1 ng/mL of rmIFN-γ. |
Storage And Stability : | This lyophilized protein is stable for six to twelve months when stored desiccated at -20°Cto -70°C. After aseptic reconstitution, this protein may be stored at 2°Cto 8°Cfor one month or at -20°Cto -70°Cin a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions. |
Gene Name : | Ifngr1 interferon gamma receptor 1 [ Mus musculus ] |
Synonyms : | Ifngr1; interferon gamma receptor 1; Ifgr; CD119; Ifngr; Nktar; IFN-gammaR; IFN-gamma R; INF-g receptor |
Gene ID : | 15979 |
mRNA Refseq : | NM_010511 |
Protein Refseq : | NP_034641 |
UniProt ID : | P15261 |
Chromosome Location : | 10 A3; 10 15.0 cM |
Pathway : | Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway; Natural killer cell mediated cytotoxicity |
Function : | cytokine binding; receptor activity |
Products Types
◆ Recombinant Protein | ||
IFNGR1-062H | Recombinant Human IFNGR1 Protein, C-His-tagged | +Inquiry |
Ifngr1-1652M | Recombinant Mouse Ifngr1 Protein, His-tagged | +Inquiry |
Ifngr1-6954M | Active Recombinant Mouse Ifngr1 protein(Met1-Asp253), His-tagged | +Inquiry |
IFNGR1-001H | Recombinant Human IFNGR1 Protein, His-tagged | +Inquiry |
IFNGR1-297H | Recombinant Human IFNGR1 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
IFNGR1-1775MCL | Recombinant Mouse IFNGR1 cell lysate | +Inquiry |
IFNGR1-1003CCL | Recombinant Cynomolgus IFNGR1 cell lysate | +Inquiry |
IFNGR1-2646HCL | Recombinant Human IFNGR1 cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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