Recombinant Human SRC protein, His-tagged

Cat.No.: SRC-29696TH
Product Overview: Recombinant Human SRC fused with His tag at N-terminal was expressed in Insect cells.
Description: This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.
Source: Insect cells
Species: Human
Tag: His
Form: 25 mM Tris-HCl, pH 8.0, 69 mM NaCl, 1.35 mM KCl, 0.025% Tween-20, 125 mM imidazole, 50% glycerol, and 3 mM DTT
Bio-activity: 205 pmol/min/μg
Molecular Mass: 60.5 kDa
Purity: > 85%
Applications: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Storage: >6 months at –80 centigrade. Avoid freeze/thaw cycles
Concentration: 1.2 mg/ml
Gene Name: SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [ Homo sapiens ]
Official Symbol: SRC
Synonyms: SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian); SRC1, v src avian sarcoma (Schmidt Ruppin A 2) viral oncogene homolog; proto-oncogene tyrosine-protein kinase Src; ASV; c src; proto-oncogene c-Src; tyrosine kinase pp60c-src; tyrosine-protein kinase SRC-1; protooncogene SRC, Rous sarcoma; SRC1; c-SRC; p60-Src;
Gene ID: 6714
mRNA Refseq: NM_005417
Protein Refseq: NP_005408
MIM: 190090
UniProt ID: P12931
Chromosome Location: 20q12-q13
Pathway: ADP signalling through P2Y purinoceptor 1, organism-specific biosystem; Adaptive Immune System, organism-specific biosystem; Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; Alpha-synuclein signaling, organism-specific biosystem;
Function: ATP binding; SH2 domain binding; SH3/SH2 adaptor activity; ephrin receptor binding; heme binding; integrin binding; ion channel binding; kinase activity; non-membrane spanning protein tyrosine kinase activity;

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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