Recombinant Human TIMP3

• Cat.No.: TIMP3-31151TH
• Product Overview: Recombinant human TIMP3 (latent form) purified from transfected BHK cells.

Specification

• Description: This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsbys fundus dystrophy.
• Form: Liquid
• Storage buffer: Preservative: NoneConstituents: 50% Glycerol, PBS, pH 7.4.
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the protease inhibitor I35 (TIMP) family.Contains 1 NTR domain.

Gene Information

• Gene Name: TIMP3 TIMP metallopeptidase inhibitor 3 [ Homo sapiens ]
• Official Symbol: TIMP3
• Synonyms: TIMP3; TIMP metallopeptidase inhibitor 3; SFD, tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory); metalloproteinase inhibitor 3
• Gene ID: 7078
• mRNA Refseq: NM_000362
• Protein Refseq: NP_000353
• MIM: 188826
• Uniprot ID: P35625
• Chromosome Location: 22q12.3
• Pathway: Endochondral Ossification, organism-specific biosystem; Matrix Metalloproteinases, organism-specific biosystem
• Function: enzyme inhibitor activity; metal ion binding; metalloendopeptidase inhibitor activity; protein binding