Recombinant Human TNFSF13B

• Cat.No.: TNFSF13B-26302TH
• Product Overview: Recombinant full length Human BAFF, amino acids 134-285.

Specification

• Description: The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells. Alternatively spliced transcript variants encoding distinct isoforms have been identified.
• Tissue specificity: Abundantly expressed in peripheral blood Leukocytes and is specifically expressed in monocytes and macrophages. Also found in the spleen, lymph node, bone marrow, T-cells and dendritic cells. A lower expression seen in placenta, heart, lung, fetal liver,
• Biological activity: The ED50 of TNFSF13B-26302TH is typically 5-10 ng/ml as measured by its ability to neutralise dexamethasone toxicity using the RPMI 8226 cell line.
• Form: Lyophilised:It is recommended that 0.5 ml of sterile phosphate-buffered saline be added to the vial.Following reconstitution short-term storage at 4°C is recommended, with longer-term storage in aliquots at -18 to -20°C. Repeated freeze thawing is not rec
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 10% Trehalose, 1% Human serum albumin
• Storage: Store at +4°C.
• Sequences of amino acids: Theoretical sequence:AVQGPEETVTQDCLQLIADSETPTIQKGS YTFVPWLLSFKRGSALEEKENKILVKETGYFFIYGQVL YTDKTYAMGHLIQRKKVHVFGDELSLVTLFRCIQNMPE TLPNNSCYSAGIAKLEEGDELQLAIPRENAQISLDGDVTFFGALKLL
• Sequence Similarities: Belongs to the tumor necrosis factor family.

Gene Information

• Gene Name: TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b [ Homo sapiens ]
• Official Symbol: TNFSF13B
• Synonyms: TNFSF13B; tumor necrosis factor (ligand) superfamily, member 13b; TNFSF20; tumor necrosis factor ligand superfamily member 13B; BAFF; BLYS; CD257; TALL 1; TALL1; THANK
• Gene ID: 10673
• mRNA Refseq: NM_001145645
• Protein Refseq: NP_001139117
• MIM: 603969
• Uniprot ID: Q9Y275
• Chromosome Location: 13q32-q34
• Pathway: Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Intestinal immune network for IgA production, organism-specific biosystem; Intestinal immune network for IgA production, conserved biosystem; Rheumatoid arthritis, organism-specific biosystem
• Function: cytokine activity; protein binding; receptor binding; tumor necrosis factor receptor binding