Recombinant Human TNK2

• Cat.No.: TNK2-26295TH
• Product Overview: Recombinant fragment, corresponding to amino acids 110-476 of Human ACK1 with N-terminal proprietary tag expressed in a Baculovirus infected Sf9 cell expression system, 66kDa.

Specification

• Description: This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined.
• Biological activity: The Specific activity of TNK2-26295TH was determined to be 20 nmol/min/mg.
• Form: Liquid
• Storage buffer: Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.

Gene Information

• Gene Name: TNK2 tyrosine kinase, non-receptor, 2 [ Homo sapiens ]
• Official Symbol: TNK2
• Synonyms: TNK2; tyrosine kinase, non-receptor, 2; activated CDC42 kinase 1; ACK; ACK1; activated Cdc42 associated kinase 1; p21cdc42Hs
• Gene ID: 10188
• mRNA Refseq: NM_001010938
• Protein Refseq: NP_001010938
• MIM: 606994
• Uniprot ID: Q07912
• Chromosome Location: 3q29
• Pathway: CDC42 signaling events, organism-specific biosystem; EGFR1 Signaling Pathway, organism-specific biosystem; Focal Adhesion, organism-specific biosystem; G13 Signaling Pathway, organism-specific biosystem
• Function: ATP binding; GTPase inhibitor activity; metal ion binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding