Recombinant Human AKR1A1
Cat.No. : | AKR1A1-485H |
Product Overview : | Recombinant humanAlcohol dehydrogenase was expressed inE.coliand purified by using conventional chromatography techniques. MW =36.5 kDa (325aa). |
- Specification
- Gene Information
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Cat. No. : | AKR1A1-485H |
Description : | Alcohol dehydrogenase [NADP+] (AKR1A1) is a member of the aldo/keto reductase superfamily and catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. This protein is closely related (65% identity) to aldose reductase, an enzyme involved in the pathogenesis of some diabetic and galactosemic complications. It plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN). |
Source : | E.coli. |
Amino Acid Sequence : | MAASCVLLHT GQKMPLIGLG TWKSEPGQVK AAVKYALSVG YRHIDCAAIY GNEPEIGEAL KEDVGPGKAV PREELFVTSK LWNTKHHPED VEPALRKTLA DLQLEYLDLY LMHWPYAFER GDNPFPKNAD GTICYDSTHY KETWKALEAL VAKGLVQALG LSNFNSRQID DILSVASVRP AVLQVECHPY LAQNELIAHC QARGLEVTAY SPLGSSDRAW RDPDEPVLLE EPVVLALAEKYGRSPAQILL RWQVQRKVIC IPKSITPSRI LQNIKVFDFT FSPEEMKQLN ALNKNWRYIV PMLTVDGKRV PRDAGHPLYP FNDPY |
Form : | Liquid. In 20mM Tris-HCl buffer (pH8.0) containing 50mM NaCl, 10% glycerol. |
Purity : | > 90% by SDS – PAGE. |
Concentration : | 1 mg/ml (determined by Bradford assay). |
Storage : | Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles. |
Gene Name : | AKR1A1 aldo-keto reductase family 1, member A1 (aldehyde reductase) [ Homo sapiens ] |
Synonyms : | AKR1A1; aldo-keto reductase family 1, member A1 (aldehyde reductase); ALR; ARM; DD3; ALDR1; MGC1380; MGC12529; OTTHUMP00000009240; aldehyde reductase; alcohol dehydrogenase; dihydrodiol dehydrogenase 3; EC 1.1.1.2; Alcohol dehydrogenase [NADP+]; Aldo-keto reductase family 1 member A1; OTTHUMP00000009241; aldo-keto reductase family 1, member A1 |
Gene ID : | 10327 |
mRNA Refseq : | NM_006066 |
Protein Refseq : | NP_006057 |
MIM : | 103830 |
UniProt ID : | P14550 |
Chromosome Location : | 1p33-p32 |
Pathway : | Glycerolipid metabolismC; Glycolysis / Gluconeogenesis; Metabolic pathways |
Function : | L-glucuronate reductase activity; alcohol dehydrogenase (NADP+) activity; aldehyde reductase activity; electron carrier activity; oxidoreductase activity; protein binding |
Products Types
◆ Recombinant Protein | ||
AKR1A1-2495H | Recombinant Human AKR1A1 protein(Met1-Tyr325), His-tagged | +Inquiry |
Akr1a1-1582M | Recombinant Mouse Akr1a1 Protein, Myc/DDK-tagged | +Inquiry |
AKR1A1-251R | Recombinant Rat AKR1A1 Protein, His (Fc)-Avi-tagged | +Inquiry |
AKR1A1-303H | Recombinant Human AKR1A1 Protein, His (Fc)-Avi-tagged | +Inquiry |
AKR1A1-119R | Recombinant Rhesus Macaque AKR1A1 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
AKR1A1-8932HCL | Recombinant Human AKR1A1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (12)
Ask a questionAKR1A1 protein is involved in many diseases, such as metabolic diseases, tumors, autoimmune diseases, etc.
The AKR1A1 protein is a REDOX enzyme capable of reducing and oxidizing a variety of compounds, such as toxins and drugs, to maintain the stability of the internal and external environment of the cell.
AKR1A1 protein inhibitors have been used in the treatment of leukemia, AIDS, diabetes and other diseases.
This protein mainly plays a role in liver, lung, eye, intestine, kidney, prostate, stomach and other parts and a variety of cells, such as germ cells, neurons, alveolar epithelial cells, liver cells and so on.
AKR1A1 protein plays an important role in various metabolic processes, such as the metabolism of vitamin A and various hormones.
AKR1A1 protein is associated with the metabolism and toxicity of many drugs, such as phenol, pyruvate, acetaminophen, etc.
The expression level of AKR1A1 protein is related to the therapeutic effect of certain drugs on diseases.
The high expression of AKR1A1 protein is associated with the occurrence and development of many diseases, such as tumors, metabolic diseases, and autoimmune diseases.
AKR1A1 protein gene mutation has a certain relationship with the occurrence of some diseases, such as tumors, metabolic diseases and so on.
AKR1A1 protein plays a role in tumor cell growth and apoptosis.
The expression level of AKR1A1 in liver cancer cells and other tumor cells is different from that in normal cells and is closely related to the proliferation and metastasis of tumor cells.
AKR1A1 protein plays a more prominent role in metabolic reduction than other proteins, and its deposition and expression levels are closely related to the occurrence and development of a variety of diseases.
Customer Reviews (4)
Write a reviewHave high sensitivity and specificity in biosensor preparation.
It promoted cell growth and proliferation.
Good selectivity for specific disease-related targets.
Iinhibitory or killing effect on specific pathogens.
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