Recombinant Human EIF4E protein
Cat.No. : | EIF4E-2050H |
Product Overview : | Recombinant Human EIF4E was expressed in E. coli. |
- Specification
- Gene Information
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Description : | Eukaryotic translation is a complex biochemical process requiring several initiation factors. The first step in the initiation of mRNA translation involves binding of the small ribosomal subunit to mRNA. The central component in the recruitment of the pre-initiation complex during translation is the eukaryotic initiation factor 4F (eIF4F) complex, composed of eIF4A, eIF4E, and eIF4G1/eIF4G3. The 5’-terminal end of eukaryotic mRNA has a common cap structure that is important for stabilizing mRNA and ribosome binding. The eIF4E component binds specifically to the mRNA cap structure to initiate protein synthesis by recognizing methyl-7-guanosine. eIFA is a DEAD-box helicase, responsible for unwinding the mRNA, while eIF4G acts as a scaffold protein with binding sites for the poly(A)-binding protein and eIF3. eIF4G also possesses central and C-terminal eIF4A binding sites and a C-terminal binding site for the protein kinase Mnk1 (mitogen-activated protein kinase-interacting kinase). Mnk1 phosphorylates eIF4E at Ser209, which is believed to be essential for eIF4E’s oncogenic potential. Further, overexpression of eIF4e is seen in many human malignancies, including breast, colon, head and neck carcinomas, and others. |
Source : | E. coli |
Species : | Human |
Form : | 20 mM sodium phosphate, pH 7.3, containing 100 mM sodium chloride, 100 µM TCEP, and 20% glycerol |
Molecular Mass : | 25.2 kDa |
Protein length : | 2-217 |
Purity : | ≥90% |
Storage : | Store product at –80 centigrade. |
Gene Name : | EIF4E eukaryotic translation initiation factor 4E [ Homo sapiens ] |
Official Symbol : | EIF4E |
Synonyms : | EIF4E; eukaryotic translation initiation factor 4E; EIF4EL1, EIF4F; EIF4E1; eIF-4E; eIF-4F 25 kDa subunit; mRNA cap-binding protein; eukaryotic translation initiation factor 4E-like 1; CBP; EIF4F; EIF4EL1; MGC111573; |
Gene ID : | 1977 |
mRNA Refseq : | NM_001130678 |
Protein Refseq : | NP_001124150 |
MIM : | 133440 |
UniProt ID : | P06730 |
Products Types
◆ Recombinant Protein | ||
EIF4E-39H | Recombinant Human EIF4E Protein (1-217), N-His tagged | +Inquiry |
Eif4e-811M | Recombinant Mouse Eif4e Protein, MYC/DDK-tagged | +Inquiry |
EIF4E-2718M | Recombinant Mouse EIF4E Protein, His (Fc)-Avi-tagged | +Inquiry |
Eif4e-5107M | Recombinant Mouse Eif4e Protein, His-tagged | +Inquiry |
EIF4E-41H | Recombinant Human EIF4E Protein Complexed With m7GTP (1-217) | +Inquiry |
◆ Lysates | ||
EIF4E-6651HCL | Recombinant Human EIF4E 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionCancer cells often exhibit elevated levels of EIF4E expression, leading to increased protein synthesis. This heightened activity is associated with tumor growth and aggressiveness.
Yes, researchers are exploring targeted therapies that aim to inhibit EIF4E activity in cancer cells. These therapies hold promise for treating certain types of cancer.
Elevated EIF4E activity in cancer cells can lead to increased synthesis of proteins involved in drug resistance mechanisms. This can reduce the effectiveness of chemotherapy and targeted therapies.
Yes, elevated EIF4E expression has been observed in some cancer types and is being investigated as a potential diagnostic and prognostic marker. However, further research is needed to establish its clinical utility.
Yes, dysregulated EIF4E expression has been associated with neurological disorders and viral infections. Researchers are studying its role in these diseases to explore potential therapeutic interventions.
Customer Reviews (3)
Write a reviewresearchers highly recommend the EIF4E protein due to its excellent performance in ELISA and its suitability for protein electron microscopy structure analysis.
Researchers can rely on the EIF4E protein's specificity and sensitivity to obtain accurate and reliable results.
The EIF4E protein comes highly recommended for a variety of applications, particularly in ELISA and protein electron microscopy structure analysis.
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