Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Human EIF4E protein

Cat.No. : EIF4E-2050H
Product Overview : Recombinant Human EIF4E was expressed in E. coli.
  • Specification
  • Gene Information
  • Related Products
Description : Eukaryotic translation is a complex biochemical process requiring several initiation factors. The first step in the initiation of mRNA translation involves binding of the small ribosomal subunit to mRNA. The central component in the recruitment of the pre-initiation complex during translation is the eukaryotic initiation factor 4F (eIF4F) complex, composed of eIF4A, eIF4E, and eIF4G1/eIF4G3. The 5’-terminal end of eukaryotic mRNA has a common cap structure that is important for stabilizing mRNA and ribosome binding. The eIF4E component binds specifically to the mRNA cap structure to initiate protein synthesis by recognizing methyl-7-guanosine. eIFA is a DEAD-box helicase, responsible for unwinding the mRNA, while eIF4G acts as a scaffold protein with binding sites for the poly(A)-binding protein and eIF3. eIF4G also possesses central and C-terminal eIF4A binding sites and a C-terminal binding site for the protein kinase Mnk1 (mitogen-activated protein kinase-interacting kinase). Mnk1 phosphorylates eIF4E at Ser209, which is believed to be essential for eIF4E’s oncogenic potential. Further, overexpression of eIF4e is seen in many human malignancies, including breast, colon, head and neck carcinomas, and others.
Source : E. coli
Species : Human
Form : 20 mM sodium phosphate, pH 7.3, containing 100 mM sodium chloride, 100 µM TCEP, and 20% glycerol
Molecular Mass : 25.2 kDa
Protein length : 2-217
Purity : ≥90%
Storage : Store product at –80 centigrade.
Gene Name : EIF4E eukaryotic translation initiation factor 4E [ Homo sapiens ]
Official Symbol : EIF4E
Synonyms : EIF4E; eukaryotic translation initiation factor 4E; EIF4EL1, EIF4F; EIF4E1; eIF-4E; eIF-4F 25 kDa subunit; mRNA cap-binding protein; eukaryotic translation initiation factor 4E-like 1; CBP; EIF4F; EIF4EL1; MGC111573;
Gene ID : 1977
mRNA Refseq : NM_001130678
Protein Refseq : NP_001124150
MIM : 133440
UniProt ID : P06730

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (5)

Ask a question
How does EIF4E protein expression differ in cancer cells compared to normal cells? 01/28/2022

Cancer cells often exhibit elevated levels of EIF4E expression, leading to increased protein synthesis. This heightened activity is associated with tumor growth and aggressiveness.

Are there any targeted therapies or drugs designed to modulate EIF4E protein activity? 11/22/2021

Yes, researchers are exploring targeted therapies that aim to inhibit EIF4E activity in cancer cells. These therapies hold promise for treating certain types of cancer.

How does EIF4E protein contribute to the development of drug resistance in cancer cells? 07/08/2021

Elevated EIF4E activity in cancer cells can lead to increased synthesis of proteins involved in drug resistance mechanisms. This can reduce the effectiveness of chemotherapy and targeted therapies.

Can EIF4E protein levels be used as a diagnostic or prognostic marker for cancer? 03/05/2021

Yes, elevated EIF4E expression has been observed in some cancer types and is being investigated as a potential diagnostic and prognostic marker. However, further research is needed to establish its clinical utility.

Apart from cancer, are there any other diseases where dysregulated EIF4E protein has been implicated? 10/23/2020

Yes, dysregulated EIF4E expression has been associated with neurological disorders and viral infections. Researchers are studying its role in these diseases to explore potential therapeutic interventions.

Customer Reviews (3)

Write a review
Reviews
02/20/2019

    researchers highly recommend the EIF4E protein due to its excellent performance in ELISA and its suitability for protein electron microscopy structure analysis.

    02/09/2017

      Researchers can rely on the EIF4E protein's specificity and sensitivity to obtain accurate and reliable results.

      07/10/2016

        The EIF4E protein comes highly recommended for a variety of applications, particularly in ELISA and protein electron microscopy structure analysis.

        Ask a Question for All EIF4E Products

        Required fields are marked with *

        My Review for All EIF4E Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends