Recombinant Human Prostaglandin E Synthase

• Cat.No.: PTGES-583H
• Product Overview: Recombinant Human PTGES isolated from a baculovirus overexpression system inSf21 cells. MW = 21 kDa.

Specification

• Cat. No.: PTGES-583H
• Description: Prostaglandin E synthases (PGESs) are enzymes that convert cyclooxygenase (COX)-derived PGH2 to PGE2. There are three different PGES enzymes with distinct enzymatic properties, modes of expression, cellular and subcellular localizations, and intracellular functions, two of which are membrane-bound enzymes and have been designated as mPGES-1 and mPGES-2. mPGES-1 is a perinuclear protein belonging to the membrane-associated proteins involved in eicosanoid and glutathione metabolism (MAPEG) superfamily.2 It requires glutathione as an essential cofactor for activity. mPGES-1 is up-regulated in response to various proinflammatory stimuli with a concomitant increased expression of COX-2 and is down-regulated by glucocorticoids.3 mPGES-1 gene knockout studies in mice have indicated a role for mPGES-1-generated PGE2 in female reproduction, inflammation, pain, fever, anorexia, atherosclerosis, stroke, and tumorigenesis. Therefore, mPGES-1 is a potential drug target for various diseases.
• Source: Sf21 cells.
• Purity: 16,000 x g supernatant.
• Formulation: A solution in 50 mM sodium phosphate, pH 7.2, containing 100 mM sodium chloride and 20% glycerol.
• Storage: ≥6 months at -80°C; avoid freeze/thaw cycles by aliquoting the protein and storing at -80°C.

Gene Information

• Gene Name: PTGES prostaglandin E synthase [ Homo sapiens ]
• Synonyms: PTGES; prostaglandin E synthase; PGES; MPGES; PIG12; PP102; PP1294; MGST-IV; MGST1L1; TP53I12; mPGES-1; MGC10317; MGST1-L1; MGST1-like 1; p53-induced gene 12 protein; p53-induced apoptosis protein 12; glutathione S-transferase 1-like 1; microsomal prostaglandin E synthase-1; tumor protein p53 inducible protein 12; microsomal glutathione S-transferase 1-like 1; EC 5.3.99.3
• Gene ID: 9536
• mRNA Refseq: NM_004878
• Protein Refseq: NP_004869
• MIM: 605172
• UniProt ID: O14684
• Chromosome Location: 9q34.3
• Pathway: Arachidonic acid metabolism; Metabolic pathways
• Function: isomerase activity; prostaglandin-E synthase activity