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Cat. No. |
AASDHPPT-797H |
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Product Overview |
Recombinant human
AASDHPPT protein, fused to His-tag at N-terminus, was expressed in
E.coli and purified by using conventional chromatography. MW = 36.4
kDa(316aa), confirmed by MALDI-TOF. |
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Description |
AASDHPPT belongs to the
P-Pant transferase superfamily. This protein catalyzes the
post-translational modification of target proteins by phosphopantetheine
and can transfer the 4"-phosphopantetheine moiety from coenzyme A to a
serine residue of a broad range of acceptors, such as the acyl carrier
domain of FASN (in vitro). It is detected in heart, skeletal muscle,
placenta, testis, brain, pancreas, liver and kidney.
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Source |
E.coli. |
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Sequences Of Amino
Acids |
MGSSHHHHHH SSGLVPRGSH
MEGVRWAFSC GTWLPSRAEW LLAVRSIQPE EKERIGQFVF ARDAKAAMAG RLMIRKLVAE
KLNIPWNHIR LQRTAKGKPV LAKDSSNPYP NFNFNISHQG DYAVLAAEPE LQVGIDIMKT
SFPGRGSIPE FFHIMKRKFT NKEWETIRSF KDEWTQLDMF YRNWALKESF IKAIGVGLGF
ELQRLEFDLS PLNLDIGQVY KETRLFLDGE EEKEWAFEES KIDEHHFVAV ALRKPDGSRH
QDVPSQDDSK PTQRQFTILN FNDLMSSAVP MTPEDPSFWD CFCFTEEIPI RNGTKS |
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Purity |
> 95% by SDS – PAGE.
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Form |
Liquid. In 20 mM
Tris-HCl Buffer (pH 8.0) containing 1 mM DTT, 10% Glycerol. |
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Concentration |
1 mg/ml (determined by
Bradford assay). |
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Storage |
Can be stored at +4oC
short term (1-2 weeks). For long term storage, aliquot and store at
-20oC or -70oC. Avoid repeated freezing and thawing cycles. |
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Gene Information
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Gene Name |
AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl
transferase [ Homo sapiens ] |
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Synonyms |
AASDHPPT;
aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase;
LYS2; LYS5; CGI-80; AASD-PPT; DKFZp566E2346; L-aminoadipate-semialdehyde
dehydrogenase-phosphopantetheinyl transferase; LYS5 ortholog;
4"-phosphopantetheinyl transferase; alpha-aminoadipic semialdehyde
dehydrogenase-phosphopantetheinyl transferase; EC 2.7.8.- |
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GeneID |
60496 |
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mRNA Refseq |
NM_015423 |
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Protein Refseq |
NP_056238 |
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MIM |
607756 |
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UniProt ID |
Q9NRN7 |
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Chromosome Location |
11q22 |
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Pathway |
Lysine biosynthesis;
Lysine degradation; Metabolic pathways |
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Function |
holo-[acyl-carrier-protein] synthase activity; magnesium ion binding;
protein binding; transferase activity |
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