Human Angiotensin I(Synthetic) Reference standard
Cat.No. : | AGT-81H |
Product Overview : | Calibrant for angiotensin I assays. |
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Species : | Human |
Enzyme Unit : | Each ampoule contains angiotensin I approx. 2.6 μg. |
Usage : | No attempt should be made to weigh out any portion of the freeze-dried material prior to reconstitution. For all practical purposes each ampoule contains the same amount of the same materials. Dissolve the total contents in a known amount of suitable buffer solution with carrier protein (free of peptidase), where extensive dilution is required, to minimise loss by surface adsorption. For economy of use it is recommended that the solution be subdivided into several small containers, which are frozen rapidly to below –40°C and then stored below –40°C in the dark. Repeated freezing and thawing should be avoided. |
Notes : | This preparation is not for administration to humans. The preparation contains material of human origin, and either the final product or the source materials, from which it is derived, have been tested and found negative for HBsAg, anti-HIV and HCV RNA. As with all materials of biological origin, this preparation should be regarded as potentially hazardous to health. It should be used and discarded according to your own laboratorys safety procedures. Such safety procedures should include the wearing of protective gloves and avoiding the generation of aerosols. Care should be exercised in opening ampoules or vials, to avoid cuts. |
Stability : | They remain valid with the assigned potency and status until withdrawn or amended. Reference materials are held at Creative Biomart within assured, temperature-controlled storage facilities. Reference Materials should be stored on receipt as indicated on the label. In addition, once reconstituted, diluted or aliquoted, users should determine the stability of the material according to their own method of preparation, storage and use. Users who have data supporting any deterioration in the characteristics of any reference preparation are encouraged to contact Creative Biomart. |
Storage : | Store at -20°C or below. Please note: because of the inherent stability of lyophilized material, Creative Biomart may ship these materials at ambient temperature. |
Tag : | Non |
Gene Name : | AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) [ Homo sapiens ]; |
Official Symbol : | AGT |
Synonyms : | AGT; angiotensinogen (serpin peptidase inhibitor, clade A, member 8); SERPINA8; angiotensinogen; alpha 1 antiproteinase; antitrypsin; serpin A8; angiotensin I; angiotensin II; pre-angiotensinogen; alpha-1 antiproteinase, antitrypsin; serine (or cysteine) proteinase inhibitor; ANHU; |
Gene ID : | 183 |
mRNA Refseq : | NM_000029 |
Protein Refseq : | NP_000020 |
UniProt ID : | P01019 |
Chromosome Location : | 1q42.2 |
Pathway : | ACE Inhibitor Pathway, organism-specific biosystem; Adipogenesis, organism-specific biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem; G alpha (i) signalling events, organism-specific biosystem; G alpha (q) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; |
Function : | acetyltransferase activator activity; growth factor activity; hormone activity; hormone activity; serine-type endopeptidase inhibitor activity; type 1 angiotensin receptor binding; type 2 angiotensin receptor binding; |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Write a reviewThe proteins offering reliable results and contributing to the success of my experiments.
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Q&As (10)
Ask a questionAGT is produced and released by the kidneys, and it plays a role in regulating renal blood flow and glomerular filtration rate, thereby impacting overall kidney function.
AGT is the precursor molecule for angiotensin peptides, including angiotensin I and angiotensin II, which are key regulators of blood pressure, fluid balance, and cardiovascular homeostasis.
AGT-derived angiotensin II plays a critical role in vasoconstriction, sodium reabsorption, and the regulation of aldosterone secretion, all of which influence blood pressure.
AGT and the renin-angiotensin system have been implicated in the central regulation of blood pressure, fluid balance, and neuroendocrine functions.
AGT is cleaved by the enzyme renin to generate angiotensin I, which is subsequently converted to angiotensin II by the enzyme angiotensin-converting enzyme (ACE).
AGT expression is regulated by various factors, including hormones (such as aldosterone and glucocorticoids), cytokines, and environmental stimuli.
AGT and its derivatives, such as angiotensin II, can promote inflammation and tissue remodeling through interactions with receptors and signaling pathways.
Experimental techniques used to study AGT include molecular biology approaches, gene expression analysis, protein quantification, immunohistochemistry, and animal models.
Genetic variations in the AGT gene have been associated with an increased risk of hypertension, cardiovascular diseases, and other conditions influenced by the renin-angiotensin system.
AGT levels and the renin-angiotensin system play a role in regulating blood pressure during pregnancy, and dysregulation can contribute to disorders such as preeclampsia.
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