As a leading biotechnology services supplier, Creative Biomart offers synthetic polymer PEG modification and bioconjugation services by site specific ligation of polyethylene glycol to peptide/proteins, oligonucleotides, antibodies, lectins, enzymes, toxins, drugs or other small molecules as delivery technology in variety of applications. With our expertise as a leader in the field of PEGylation, Creative Biomart has created a set of new platform technologies.
Common limits for therapeutic application of peptides and proteins are their chemical instability, their short residence time in blood and their tendency to promote an immunological response. Most of these problems may be solved by linking one or more PEG (polyethylene glycol) molecules to these peptides and proteins (PEGylation). This is achieved due to the combination of increased molecular weight and coverage of epitopes or blockage of sequences prone to enzymatic degradation. In addition, PEGylation enhances protein solubility in aqueous solutions.
Currently available PEGylation technologies produce products which are PEGylated at multiple sites in an uncontrolled manner. This inevitably results in a population of molecules PEGylated in locations which crowd the active centre or binding regions resulting in a net decrease in potency versus the un-PEGylated analogue.
Creative Biomart's chemists will perform your PEGylation service in a professional and efficient way to provide you the PEGylated products in very short period of time and with high quality.
PEG-CtrlTM is a novel site-selective PEGylation platform, using a proprietary efficient and cost-effective PEGylation chemistry, which is suitable to a large variety of proteins.
The PEG-CtrlTM unique approach enables homogeneous PEGylated populations where the specific PEGylation site can be selected and controlled, thus improving efficacy compared to existing PEGylation techniques, decreasing cost of goods and substance dosed to patient; while still providing an improved ADME profile due to the addition of the PEG moiety.
Creative Biomart currently provides two service models to meet customer's different PEGylation needs:
Provide PEGylation service for you as a regular customer product.
This is the economic way for you if you want to get an initial evaluation of your PEGylation approach.
Complete PEGylation method development service
Under this service model, we will provide your PEGylated sample as well as the complete PEGylation method development package. The PEGylation process Creative Biomart developed for you will be easily scalable and easily transferable with all the necessary analytical methods developed in the same time.
Increased intellectual property value
Site-specific modifications and linkers
Consistent lot to lot characterization and biological activity
Please explore our PEG derivative products at our chemistry division BOC Sciences, or contact us to see how we can meet your needs for PEG or pegylation products via our custom synthesis service.