Recombinant Human AKR1C3 Protein, His-tagged

• Cat.No.: AKR1C3-090H
• Product Overview: Active recombinant C-terminal His-tagged human AKR1C3 protein (1-323) was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 1-323
• Description: This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding different isoforms have been found for this gene.
• Molecular Mass: 40.4 kDa
• Purity: ≥85% estimated by SDS-PAGE
• Unit Definition: One unit is defined as the amount of enzyme required to produce 1 μmol of NADP+, per minute at 37 centigrade in 50 mM KPO4 pH7.2 containing 250 μM NADPH and 25 μM 9,10-phenanthrenequinone.
• Stability: ≥ 1 year
• Storage: At -80 centigrade.
• Storage Buffer: A solution in 100 mM sodium phosphate, pH 7.2, containing 20% glycerol, 100 mM sodium chloride, and 1 mM EDTA

Gene Information

• Gene Name: AKR1C3 aldo-keto reductase family 1 member C3 [ Homo sapiens (human) ]
• Official Symbol: AKR1C3
• Synonyms: AKR1C3; aldo-keto reductase family 1 member C3; DD3; DDX; PGFS; HAKRB; HAKRe; HA1753; HSD17B5; hluPGFS; aldo-keto reductase family 1 member C3; 3-alpha hydroxysteroid dehydrogenase, type II; 3-alpha-HSD type II, brain; chlordecone reductase homolog HAKRb; dihydrodiol dehydrogenase 3; dihydrodiol dehydrogenase X; indanol dehydrogenase; prostaglandin F synthase; testosterone 17-beta-dehydrogenase 5; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; type IIb 3-alpha hydroxysteroid dehydrogenase; EC 1.1.1.188; EC 1.1.1.210; EC 1.1.1.239; EC 1.1.1.357; EC 1.1.1.53; EC 1.1.1.62; EC 1.1.1.64
• Gene ID: 8644
• mRNA Refseq: NM_003739
• Protein Refseq: NP_003730
• MIM: 603966
• UniProt ID: P42330