Recombinant Human Fas Ligand (TNF superfamily, member 6), His-tagged
Cat.No. : | FASLG-5412H |
Product Overview : | Recombinant Human soluble Fas Ligandcontains 175 amino acid residues and comprises the TNF homologous region ofFast plus an eight His-Tag. |
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Cat. No. : | FASLG-5412H |
Description : | FASLG is a type-IItransmembrane protein that belongs to the tumor necrosis factor (TNF) family.Its binding with its receptor induces apoptosis. Fas ligand/receptorinteractions play an important role in the regulation of the immune systemand the progression of cancer. |
Source : | CHO cells |
Species : | Human |
Form : | Lyophilized withoutadditives. |
Molecular Weight : | 17.9 kDa |
Purity : | <95% by RP-HPLC and SDS-PAGE. |
Endotoxin Level : | <0.1 ng/ug |
Biological Activity : | Determined by itsability to induce cytotoxicity in Jurkat cells in the absence of anycross-linking. The EDSO for this effect is <10.0 ng/ml. |
Specific Activity : | < 1 x 105units/mg |
Reconstitution : | Centrifuge vialprior to opening. First add sterile distilled water to the vial to fullysolubilize the protein to a concentration of 0.1-1.0 mg/ml. After completesolubilization of the protein, it can be further diluted to other aqueoussolutions. |
Storage : | Store lyophilizedprotein at -20°C and reconstituted protein in working aliquots at -20°C.Avoid repeated freeze-thaw cycles. |
OfficialSymbol : | FASLG |
Gene Name : | FASLG Fas ligand (TNFsuperfamily, member 6) [ Homo sapiens ] |
Synonyms : | FASLG; Fas ligand(TNF superfamily, member 6); FASL; CD178; CD95L; CD95-L; TNFSF6; APT1LG1; tumor necrosis factor ligand superfamily member 6; APTL; CD95ligand; OTTHUMP00000032708; fas antigen ligand; apoptosis antigen ligand;apoptosis (APO-1) antigen ligand 1; tumor necrosis factor (ligand)superfamily, member 6 |
Gene ID : | 356 |
mRNA Refseq : | NM_000639 |
Protein Refseq : | NP_000630 |
MIM : | 134638 |
UniProt ID : | P48023 |
Chromosome Location : | 1q23 |
Pathway : | Activationof Pro-Caspase 8; Africantrypanosomiasis; Allograft rejection;Apoptosis; Autoimmune thyroid disease; Calcineurin-regulatedNFAT-dependent transcription in lymphocytes; Calcium signaling in the CD4+ TCR pathway; Caspase-8 is formed from procaspase-8; Death Receptor Signalling; FoxO family signaling; Influenza A; MAPKsignaling pathway; Measles; Pathways in cancer; Type I diabetes mellitus |
Function : | cytokine activity;protein binding; receptor binding; tumor necrosis factor receptor binding |
Products Types
◆ Lysates | ||
FASLG-6324HCL | Recombinant Human FASLG 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewThe outstanding level of customer service adds extra reassurance and confidence in using the FASLG protein for my scientific investigations.
the manufacturer of FASLG provides exceptional technical support, offering valuable assistance in troubleshooting and experimental design.
The FASLG protein surpasses expectations in terms of quality and will undoubtedly fulfill my experimental requirements.
Q&As (5)
Ask a questionYes, there are diagnostic tests that measure FASLG levels, which can provide insights into immune function and disease processes.
The FASLG protein can be targeted for therapeutic purposes in cancer treatment and autoimmune disease management.
Dysregulation of FASLG expression can contribute to liver injury and the progression of liver diseases such as hepatitis and liver fibrosis.
Dysregulation of FASLG expression can impact intestinal immune homeostasis and contribute to the pathogenesis of inflammatory bowel disease.
FASLG is involved in the regulation of immune responses to transplanted organs, and its dysregulation can impact transplant outcomes.
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