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Recombinant Human IL19 protein

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Product Overview:
Recombinant Human IL19(Leu25-Ala177) was expressed in NS0.
Interleukin 19 (IL-19) is a member of the IL-10 family of class II alpha -helical cytokines that contains two groups, a viral homolog and cellular homolog group. Within the cellular homolog group, there are two additional groupings, one which uses IL-10 R beta as a signal transducing receptor (IL-10, IL-22, and IL-26), and one which uses IL-20 R beta as a signal transducing receptor (IL-19, IL-20, and IL-24). The 153 amino acid (aa) mature human IL-19 is secreted as a glycosylated 35-45 kDa monomer. It shares approximately 70% aa sequence identity with mouse and rat IL-19. Human IL-19 may utilize an alternate start site that adds 38 aa to the N-terminus. Although mouse IL-19 is active on human cells, human IL-19 is not active on mouse cells. IL-19 is expressed on activated keratinocytes, monocytes, and B cells. It binds a receptor complex consisting of IL-20 R alpha and IL-20 R beta. This receptor complex is also shared by IL-20 and IL-24. It has been reported that IL-19 both will and will not induce IL-6 and TNF-alpha production by monocytes. It does, however, drive T helper cell differentiation towards a Th2 response, inducing both IL-10 and production of itself.
Predicted N Terminal:
Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Measured in a cell proliferation assay using BaF3 mouse pro‑B cells transfected with human IL-20 R alpha and human IL-20 R beta. The ED50 for this effect is typically 0.1-0.6 ng/mL.
Molecular Mass:
Predicted Molecular Mass: 18 kDa
SDS-PAGE: 20-30 kDa, reducing conditions
<0.1 EU per 1 μg of the protein by the LAL method.
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 centigrade as supplied.
1 month, 2 to 8 centigrade under sterile conditions after reconstitution.
3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
Reconstitute at 500 μg/mL in PBS.

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Optional requirements on this protein +Expand
C-fusion   N-fusion  Non-tagged
His   GST  Fc  Others
<1.0 eu/μg   <0.1 eu/μg  <0.01 eu/μg  Not required
Monomer Isolation   Dimer Isolation   Not required
>80% by SDS-PAGE   >90% by SDS-PAGE  >95% by SDS-PAGE  Others
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45-1 Ramsey Road, Shirley, NY 11967, USA
USA: 1-631-559-9269  1-631-448-7888
Europe: 44-207-048-3343
FAX: 1-631-938-8127

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