Active Recombinant Human TIMD4 protein, Fc-tagged
Cat.No. : | TIMD4-244H |
Product Overview : | Recombinant Human TIMD4(Glu25-Gln314) fused Fc region of Human IgG1 was expressed in HEK293. |
- Specification
- Gene Information
- Related Products
Description : | TIM-4 (T cell; immunoglobulin; mucin-4), also known as SMUCKLER, is a 60 kDa member of the TIM family of immune regulating proteins. TIMs are type I transmembrane proteins with one Ig-like V domain and one Ser/Thr-rich mucin domain. Mature human TIM-4 consists of a 290 aa extracellular domain (ECD), a 21 aa transmembrane segment, and a 43 aa cytoplasmic tail. Structurally, TIM-4 is distinguished from other TIMs by the presence of an RGD motif in its Ig domain and the lack of a site for tyrosine phosphorylation in its cytoplasmic tail. Within the ECD human TIM-4 shares 45% aa sequence identity with mouse and rat TIM-4. TIM-4 is expressed by macrophages and mature dendritic cells but not by lymphocytes. It binds specifically to TIM-1 which is also the cellular receptor for hepatitis A virus and has been implicated in the development of asthma. Among hematopoietic cells, TIM-1 is expressed on activated B and T cells, preferentially in the Th2 subset of CD4+ T cells. The interaction of TIM-4 with TIM-1 induces co-stimulatory and hyperproliferative signals in T cells. TIM-4 also binds to phosphatidylserine (PS) on the surface of apoptotic cells. It enhances the clearance of apoptotic cells including T cells in the contraction phase of immune responses, apoptotic macrophages that accumulate in atherosclerosis, and dying neurons in the brain. TIM-4 is upregulated on some tumor cells and tumor-associated myeloid cells where it binds Integrin alpha V beta 3, contributes to tumor progression, and inhibits tumor-specific cellular immunity. |
Source : | HEK293 |
Species : | Human |
Tag : | Fc |
Predicted N Terminal : | Glu25 |
Form : | Lyophilized from a 0.2 μm filtered solution in PBS. |
Bio-activity : | Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated human T cells. The ED50 for this effect is 0.15-0.75 μg/mL. |
Molecular Mass : | Predicted Molecular Mass: 58 kDa SDS-PAGE: 95-113 kDa, reducing conditions |
Endotoxin : | <0.1 EU per 1 μg of the protein by the LAL method. |
Purity : | >95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining. |
Storage : | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 centigrade as supplied. 1 month, 2 to 8 centigrade under sterile conditions after reconstitution. 3 months, -20 to -70 centigrade under sterile conditions after reconstitution. |
Reconstitution : | Reconstitute at 500 μg/mL in PBS. |
Gene Name : | TIMD4 T-cell immunoglobulin and mucin domain containing 4 [ Homo sapiens ] |
Official Symbol : | TIMD4 |
Synonyms : | TIMD4; T-cell immunoglobulin and mucin domain containing 4; T-cell immunoglobulin and mucin domain-containing protein 4; TIM-4; TIMD-4; T-cell membrane protein 4; TIM4; SMUCKLER; FLJ27515; |
Gene ID : | 91937 |
mRNA Refseq : | NM_001146726 |
Protein Refseq : | NP_001140198 |
MIM : | 610096 |
UniProt ID : | Q96H15 |
Products Types
◆ Recombinant Protein | ||
TIMD4-407H | Recombinant Human TIMD4 Protein, His-tagged | +Inquiry |
TIMD4-1030H | Recombinant Human TIMD4 Protein, MYC/DDK-tagged | +Inquiry |
TIMD4-2194H | Recombinant Human TIMD4 Protein, His (Fc)-Avi-tagged | +Inquiry |
TIMD4-3294H | Recombinant Human TIMD4 protein(Met 1-Leu 315), His-tagged, Biotinylated | +Inquiry |
Timd4-2209M | Recombinant Mouse Timd4 protein(Met1-Thr279), His-tagged | +Inquiry |
◆ Lysates | ||
TIMD4-2465MCL | Recombinant Mouse TIMD4 cell lysate | +Inquiry |
TIMD4-1897HCL | Recombinant Human TIMD4 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
0
Inquiry Basket