Recombinant Rat Spn protein(Met1-Gly243), hFc-tagged

• Cat.No.: Spn-50R
• Product Overview: Recombinant Rat SPN (NP_001258015.1)(Met1-Gly243) was expressed in HEK293 with the Fc region of Human IgG1 at the C-terminus.

Specification

• Source: HEK293
• Species: Rat
• Tag: C-hFc
• Protein length: Met1-Gly243
• Form: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
• Molecular Mass: The recombinant rat SPN/Fc is a disulfide-linked homodimer. The reduced monomer comprises 465 amino acids and has a predicted molecular mass of 49.3 kDa. The apparent molecular mass of the protein is approximately 95, 57 and 50 kDa in SDS-PAGE under reducing conditions due to glycosylation.
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
• Purity: > 95 % as determined by SDS-PAGE
• Storage: Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.

Gene Information

• Gene Name: Spn sialophorin [ Rattus norvegicus ]
• Official Symbol: Spn
• Synonyms: SPN; sialophorin; leukosialin; Leukosialin; W3/13 antigen; leukocyte sialoglycoprotein; Sialophorin (gpL115, leukosianin, CD43); Lsn; Cd43; Lsn1; gpL115
• Gene ID: 24796

Reviews

06/23/2023

Accurate and timely results, crucial for research progress.

10/02/2018

Instrumental in our research achievements, highly trusted.

03/26/2018

Efficient and dependable, aids our research significantly.

Q&As

What is the primary role of SPN in immune cell function?

SPN, or Sialophorin, is important in modulating the function of immune cells, particularly lymphocytes.

What potential therapeutic applications arise from targeting SPN in immune disorders?

Targeting SPN could provide new treatment approaches for managing immune-related conditions, including autoimmune diseases.

How do genetic variations in SPN affect immune response?

Genetic changes in SPN can lead to variations in immune cell behavior and effectiveness.

What role does SPN play in cell adhesion and migration?

SPN plays a role in regulating immune cell adhesion and migration, crucial for immune surveillance and response.

How does SPN interact with other components of the immune system?

SPN interacts with other immune molecules, coordinating immune cell communication and function.

What is the impact of altered SPN activity on autoimmune diseases?

Altered SPN activity can impact the regulation of immune responses, potentially leading to autoimmune disorders.

How does SPN contribute to immune cell signaling?

It contributes to immune cell signaling, influencing cell activation and response to stimuli.