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ARG1

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Official Full Name
arginase 1
Background
Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform encoded by this gene, is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Synonyms
ARG1; arginase 1; arginase-1; arginase, liver; type I arginase; liver-type arginase;
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ARG1 Related Articles
>> Wang, JH; Zhao, DM; et al. Toll-Like Receptor 2 Deficiency Shifts PrP106-126-Induced Microglial Activation from a Neurotoxic to a Neuroprotective Phenotype. JOURNAL OF MOLECULAR NEUROSCIENCE 55:880-890(2015).
>> Bieren, JEV; Volpe, B; et al. Antibody-Mediated Trapping of Helminth Larvae Requires CD11b and Fc gamma Receptor I. JOURNAL OF IMMUNOLOGY 194:1154-1163(2015).

45-1 Ramsey Road, Shirley, NY 11967, USA
USA: 1-631-559-9269  1-631-448-7888
Europe: 44-207-048-3343
FAX: 1-631-938-8127
EMAIL: info@creative-biomart.com

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