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AXL

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Official Full Name
AXL receptor tyrosine kinase
Background
The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
Synonyms
AXL; AXL receptor tyrosine kinase; UFO; JTK11; tyrosine-protein kinase receptor UFO; AXL oncogene; AXL transforming sequence/gene;
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AXL Related Articles
>> Yu, Z; Li, XC; et al. 3D-QSAR modeling and molecular docking study on Mer kinase inhibitors of pyridine-substituted pyrimidines. MOLECULAR DIVERSITY 19:135-147(2015).
>> Albert, R; Kristof, E; et al. Triamcinolone regulated apopto-phagocytic gene expression patterns in the clearance of dying retinal pigment epithelial cells. A key role of Mertk in the enhanced phagocytosis. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS 1850:435-446(2015).

45-1 Ramsey Road, Shirley, NY 11967, USA
USA: 1-631-559-9269  1-631-448-7888
Europe: 44-207-048-3343
FAX: 1-631-938-8127
EMAIL: info@creative-biomart.com

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