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BCAN

  • Official Full Name

    brevican

  • Overview

    This gene encodes a member of the lectican family of chondroitin sulfate proteoglycans that is specifically expressed in the central nervous system. This protein is developmentally regulated and may function in the formation of the brain extracellular matrix. This protein is highly expressed in gliomas and may promote the growth and cell motility of brain tumor cells. Alternate splicing results in multiple transcript variants.
  • Synonyms

    BCAN; brevican; brevican core protein; BEHAB; brevican proteoglycan; chondroitin sulfate proteoglycan 7; CSPG7; MGC13038; Brain enriched hyaluronan binding protein; Brevican core protein isoform 1; Brevican core protein isoform 2; Chondroitin sulfate proteoglycan BEHAB; brain-enriched hyaluronan-binding protein;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Insect Cells
  • Mammalian cell
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • His
  • GST
  • hFc
  • His (Fc)
  • Avi
  • Myc
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human BCAN-300H Active Recombinant Human BCAN, His-tagged Mammalian cells His
Human BCAN-114H Recombinant Human BCAN Protein, GST-tagged Wheat Germ GST
Human BCAN-10161H Recombinant Human BCAN, His-tagged E.coli His 23-350a.a.
Human BCAN-40H Recombinant Human BCAN, His-tagged HEK293 His
Human BCAN-115H Recombinant Human BCAN Protein, GST-tagged Wheat Germ GST
Human BCAN-160HCL Recombinant Human BCAN cell lysate N/A
Human BCAN-1595HF Recombinant Full Length Human BCAN Protein, GST-tagged In Vitro Cell Free System GST 911 amino acids
Human BCAN-2532H-B Recombinant Human BCAN Protein Pre-coupled Magnetic Beads HEK293
Human BCAN-2532H Recombinant Human BCAN Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human BCAN-0075H Recombinant Human BCAN Protein (Asp23-Pro911), C-His-tagged Mammalian cells C-His Asp23-Pro911
Mouse Bcan-373M Recombinant Mouse Bcan Protein, His-tagged E.coli His Asp23~Arg353
Rat Bcan-018R Recombinant Rat Bcan protein, His&Myc-tagged Insect Cells His&Myc 658-786aa
Rat Bcan-019R Recombinant Rat Bcan protein, hFc-tagged Mammalian cell hFc 658-786aa
Zebrafish BCAN-5437Z Recombinant Zebrafish BCAN Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • BCAN Related Articles

BCAN involved in several pathways and played different roles in them. We selected most pathways BCAN participated on our site, such as A tetrasaccharide linker sequence is required for GAG synthesis, CS/DS degradation, Chondroitin sulfate biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with BCAN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
A tetrasaccharide linker sequence is required for GAG synthesisVCAN;BGN;GPC1B;GPC5;GPC5A;CSPG4;B4GALT7;CSPG5;CSPG5B
CS/DS degradationBCAN;VCANB;NCAN;VCAN;DCN;CSPG4;CSPG5;BGN;CSPG5B
Chondroitin sulfate biosynthesisVCAN;CHST9;BGNA;BCAN;NCAN;BGNB;CSPG5;CSPG4;B3GAT2
Chondroitin sulfate/dermatan sulfate metabolismCSPG5B;NCAN;CHST9;UST;GPC1B;BGNA;DCN;Gpc2;B4GALT7
Defective B3GALT6 causes EDSP2 and SEMDJL1BCAN;AGRN;DCN;BGN;GPC6;GPC5;CSPG4;VCAN;NCAN
Defective B3GAT3 causes JDSSDHDBGN;CSPG4;DCN;AGRN;CSPG5;GPC5;GPC6;BCAN;VCAN
Defective B4GALT7 causes EDS, progeroid typeBCAN;AGRN;GPC6;DCN;VCAN;CSPG5;GPC5;BGN;NCAN
Defective CHST14 causes EDS, musculocontractural typeCSPG4;DCN;BCAN;BGN;CSPG5

BCAN has several biochemical functions, for example, carbohydrate binding, hyaluronic acid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BCAN itself. We selected most functions BCAN had, and list some proteins which have the same functions with BCAN. You can find most of the proteins on our site.

Function Related Protein
carbohydrate bindingCLEC1A;LGALSLA;CLEC19A;CLC;CHI3L2;WBSCR17;REG3G;GALNT11;GALNT1
hyaluronic acid bindingHYAL2;CD44;C1QBP;LYVE1;NCAN;ACAN;VCANB;IMPG2;HAPLN3

BCAN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BCAN here. Most of them are supplied by our site. Hope this information will be useful for your research of BCAN.

PCBD1; q9wmx2-pro_0000037548

Valenzuela, JC; Heise, C; et al. Hyaluronan-based extracellular matrix under conditions of homeostatic plasticity. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES 369:-(2014).
Lendvai, D; Morawski, M; et al. Neurochemical mapping of the human hippocampus reveals perisynaptic matrix around functional synapses in Alzheimer's disease. ACTA NEUROPATHOLOGICA 125:215-229(2013).
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