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   Your Position: Home >> BCL2

BCL2

Official Full Name

BCL2 B-cell CLL/lymphoma 2

Background

This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such;as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus,;is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in;their C-terminal ends.

Synonyms

BCL2; B-cell CLL/lymphoma 2; Bcl-2; PPP1R50; apoptosis regulator Bcl-2; protein phosphatase 1, regulatory subunit 50