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BCOR

Official Full Name

BCL6 corepressor
Overview

The protein encoded by this gene was identified as an interacting corepressor of BCL6, a POZ/zinc finger transcription repressor that is required for germinal center formation and may influence apoptosis. This protein selectively interacts with the POZ domain of BCL6, but not with eight other POZ proteins. Specific class I and II histone deacetylases (HDACs) have been shown to interact with this protein, which suggests a possible link between the two classes of HDACs. Several transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene is found on chromosome Y.
Synonyms

BCOR; BCL6 corepressor; BCL6 co repressor; BCL-6 corepressor; FLJ20285; KIAA1575; 5830466J11Rik; 8430401K06Rik; ANOP 2; ANOP2; BCL 6 co repressor; BCL 6 corepressor; BCL-6 interacting corepressor; FLJ38041; MAA 2; MAA2; MCOPS 2; MCOPS2; MGC131961; MGC71031; BCL6 co-repressor;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Zebrafish

Source

E.coli
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	BCOR-174H	Recombinant Human BCOR Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	BCOR-10194H	Recombinant Human BCOR, GST-tagged	E.coli	GST	C-term-360a.a.	$319 / 25ug
Human	BCOR-175H	Recombinant Human BCOR Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	BCOR-8473HCL	Recombinant Human BCOR 293 Cell Lysate	HEK293	N/A		Inquiry
Human	BCOR-556H	Recombinant Human BCOR Protein, His-tagged	E.coli	His	Leu1501~Trp1755	Inquiry
Human	BCOR-0474H	Recombinant Human BCOR Protein (Met1569-Trp1755), N-His-tagged	E.coli	N-His	Met1569-Trp1755	Inquiry
Human	BCOR-2974H	Recombinant Human BCOR protein, His-tagged	E.coli	His	2-361 aa	$319 / 25ug
Human	BCOR-1557HF	Recombinant Full Length Human BCOR Protein, GST-tagged	In Vitro Cell Free System	GST	1004 amino acids	Inquiry
Mouse	BCOR-2361M	Recombinant Mouse BCOR Protein	Mammalian Cell	His		Inquiry
Mouse	Bcor-557M	Recombinant Mouse Bcor Protein, His-tagged	E.coli	His	Leu1553~His1755	Inquiry
Mouse	BCOR-1004M-B	Recombinant Mouse BCOR Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	BCOR-1004M	Recombinant Mouse BCOR Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Zebrafish	BCOR-11661Z	Recombinant Zebrafish BCOR	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
BCOR Related Research Area

BCOR involved in several pathways and played different roles in them. We selected most pathways BCOR participated on our site, such as Signaling events mediated by HDAC Class II, which may be useful for your reference. Also, other proteins which involved in the same pathway with BCOR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Signaling events mediated by HDAC Class II	ANKRA2;GATA1;BCOR

BCOR has several biochemical functions, for example, heat shock protein binding, histone deacetylase binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BCOR itself. We selected most functions BCOR had, and list some proteins which have the same functions with BCOR. You can find most of the proteins on our site.

Function	Related Protein
heat shock protein binding	FKBP5;CDC37L1;PACRG;HSPA8;DLST;HSPA1A;KCNJ11;HDAC2;TPR
histone deacetylase binding	NCOR2;GLI3;NKX3-1;KAT2B;GMNN;RAD9;MEF2B;RELA;ANKRA2
protein binding	PLD2;ATF7;BEND5;CCL3;THOC1;EIF4EBP3;NAA38;DUSP26;CSTF1
transcription corepressor activity	TRIM22;WWTR1;PBXIP1;SMARCA4;ENO1;HSF4;TSG101;YAF2;JAZF1
transcription factor binding	GCM1;TAF1;Ar;UBN1;PSMC5;ARRB1;RB1;HES7;INSIG2
transcription regulatory region DNA binding	SALL3;FOXA3;TFAP4;XRCC6;CALCOCO1;GABPB2;NR1H3;ATMIN;KLF2A
contributes_to ubiquitin-protein transferase activity	KLHL3;KLHL20;KLHL28;BACH1;KLHL42;RNF20;TCEB3C;KCTD13;KLHDC7A

BCOR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BCOR here. Most of them are supplied by our site. Hope this information will be useful for your research of BCOR.

PCGF1; KDM2B; USP7; RING1; RNF2; proS; fabB

Tumor Suppressors