BEST3
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Official Full Name
bestrophin 3
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Overview
BEST3 belongs to the bestrophin family of anion channels, which includes BEST1 (MIM 607854), the gene mutant in;vitelliform macular dystrophy (VMD; MIM 153700), and 2 other BEST1-like genes, BEST2 (MIM 607335) and BEST4 (MIM;607336). Bestrophins are transmembrane (TM) proteins that share a homology region containing a high content of;aromatic residues, including an invariant arg-phe-pro (RFP) motif. The bestrophin genes share a conserved gene;structure, with almost identical sizes of the 8 RFP-TM domain-encoding exons and highly conserved exon-intron;boundaries. Each of the 4 bestrophin genes has a unique 3-prime end of variable length (Stohr et al., 2002 (PubMed;12032738); Tsunenari et al., 2003 (PubMed 12907679)). -
Synonyms
BEST3; bestrophin 3; vitelliform macular dystrophy 2 like 3 , VMD2L3; bestrophin-3; MGC13168; MGC40411; Vitelliform macular dystrophy 2 like protein 3; BEST 3; BEST3_HUMAN; Bestrophin3; OTTHUMP00000195114; OTTHUMP00000233491; Vitelliform macular dystrophy 2 like 3; Vitelliform macular dystrophy 2-like protein 3; VMD2L3; vitelliform macular dystrophy 2-like 3;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Homo sapiens (Human)
- Human
- Mouse
- Mus musculus (Mouse)
- E.coli
- E.coli expression system
- HEK293
- HEK293T
- Mammalian Cell
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- N
- GST
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Human | BEST3-10209H | Recombinant Human BEST3, His-tagged | E.coli | His | C-term-186a.a. | |
Human | BEST3-8466HCL | Recombinant Human BEST3 293 Cell Lysate | HEK293 | N/A | ||
Human | BEST3-3094H | Recombinant Human BEST3 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Myc/DDK | ||
Mouse | BEST3-2378M | Recombinant Mouse BEST3 Protein | Mammalian Cell | His | ||
Mouse | Best3-1860M | Recombinant Mouse Best3 Protein, Myc/DDK-tagged | HEK293T | Myc/DDK | ||
Mouse | Best3-313M | Recombinant Mouse Best3 Protein, His&GST-tagged | E.coli | N-His&GST | Glu507-Phe669 | |
Mouse | BEST3-1014M | Recombinant Mouse BEST3 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Mouse | BEST3-1014M-B | Recombinant Mouse BEST3 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Homo sapiens (Human) | RFL34325HF | Recombinant Full Length Human Bestrophin-3(Best3) Protein, His-Tagged | E.coli expression system | His | Full Length (1-668) | |
Mus musculus (Mouse) | RFL10127MF | Recombinant Full Length Mouse Bestrophin-3(Best3) Protein, His-Tagged | E.coli expression system | His | Full Length (1-669) | |
Chicken | BEST3-4453C | Recombinant Chicken BEST3 | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
BEST3 involved in several pathways and played different roles in them. We selected most pathways BEST3 participated on our site, such as Ion channel transport, Stimuli-sensing channels, Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with BEST3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Ion channel transport | ATP2C2;WNK1;ATP10A;TPCN1;ANO10A;CLCN7;ANO5;TRPA1B;ATP2C1 |
Stimuli-sensing channels | ANO5B;TRPA1A;TTYH3B;TRPA1B;TRPC5;TRPC4APB;GSDMA2;BEST3;SLC17A3 |
Transmembrane transport of small molecules | ABCC9;SLC4A3;SLC39A1;ABCG4B;BEST1;SLC4A4A;MIP;SLC43A2B;SLCO2A1 |
BEST3 has several biochemical functions, for example, contributes_to chloride channel activity, molecular_function. Some of the functions are cooperated with other proteins, some of the functions could acted by BEST3 itself. We selected most functions BEST3 had, and list some proteins which have the same functions with BEST3. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
contributes_to chloride channel activity | GABRR2;BEST2;GABRZ;GABRR2A;GABRQ;BSND;GABRB3;GABRR3A;BEST4 |
molecular_function | FHDC1;COMMD4;COL9A1A;Atp5g2;TMEM132A;NKX2-4;ZFP474;TDPOZ3;GM14692 |
BEST3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BEST3 here. Most of them are supplied by our site. Hope this information will be useful for your research of BEST3.
- Q&As
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