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BLMH

  • Official Full Name

    bleomycin hydrolase

  • Overview

    Bleomycin hydrolase (BMH) is a cytoplasmic cysteine peptidase that is highly conserved through evolution; however, the only known activity of the enzyme is metabolic inactivation of the glycopeptide bleomycin (BLM), an essential component of combination chemotherapy regimens for cancer. The protein contains the signature active site residues of the cysteine protease papain superfamily.
  • Synonyms

    BLMH; bleomycin hydrolase; BH; BLM hydrolase; BMH; EC 3.4.22.40;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human BLMH-242H Recombinant Human BLMH Protein, GST-tagged Wheat Germ GST
Human BLMH-802H Recombinant Human Bleomycin Hydrolase, His-tagged E.coli His
Human BLMH-26114TH Recombinant Human BLMH, His-tagged E.coli His 475 amino acids
Human BLMH-1155H Recombinant Human BLMH, His tagged E.coli His
Human BLMH-243H Recombinant Human BLMH Protein, GST-tagged Wheat Germ GST
Human BLMH-26116TH Recombinant Human BLMH, His-tagged E.coli His
Human BLMH-8445HCL Recombinant Human BLMH 293 Cell Lysate HEK293 N/A
Human BLMH-418H Recombinant Human BLMH Protein, His-tagged E.coli His Met213~Trp447
Human BLMH-1648HF Recombinant Full Length Human BLMH Protein, GST-tagged In Vitro Cell Free System GST 455 amino acids
Human BLMH-0765H Recombinant Human BLMH Protein (Met213-Trp447), His tagged E.coli His Met213-Trp447
Mouse Blmh-1190M Recombinant Mouse Blmh, His tagged E.coli His
Mouse BLMH-2416M Recombinant Mouse BLMH Protein Mammalian Cell His
Mouse BLMH-1041M-B Recombinant Mouse BLMH Protein Pre-coupled Magnetic Beads HEK293
Mouse Blmh-419M Recombinant Mouse Blmh Protein, His-tagged E.coli His Ala27~Cys164
Mouse BLMH-1041M Recombinant Mouse BLMH Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Blmh-420R Recombinant Rat Blmh Protein, His-tagged E.coli His Val30~Phe165
Zebrafish BLMH-10377Z Recombinant Zebrafish BLMH Mammalian Cell His
Chicken BLMH-6661C Recombinant Chicken BLMH Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • BLMH Related Articles
  • BLMH Related Research Area

BLMH involved in several pathways and played different roles in them. We selected most pathways BLMH participated on our site, such as Adaptive Immune System, Antigen processing: Ubiquitination &amp, Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with BLMH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Adaptive Immune SystemRNF41;KLRB1F;KIF26A;SIGLEC9;SEC61B;DCTN2;KLC3;RAET1E;DYNC1LI2
Antigen processing: Ubiquitination &ampTPP2;RNF6;RNF41;UBR2;ASB8;SH3RF1;TRIM63;UBE2V2;UFL1
Proteasome degradationUCHL3;RNF34;PJA1;ASB10;WWP1;LTN1;RNF182;SH3RF1;ASB17
Class I MHC mediated antigen processing &ampASB13;TPP2;UBE2U;ASB2;PJA1;RNF25;MKRN1;ASB7;RNF41
presentationUBE2F;SEC24A;RNF138;WWP1;SEC61B;CMTM2A;RNF19B;LRRC41;PJA1
Immune SystemGRAP2A;CD200R4;PAG1;RNF216;NCKIPSD;ADAR;FCN1;LRRFIP1;OSBPL1A

BLMH has several biochemical functions, for example, aminopeptidase activity, carboxypeptidase activity, cysteine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by BLMH itself. We selected most functions BLMH had, and list some proteins which have the same functions with BLMH. You can find most of the proteins on our site.

Function Related Protein
aminopeptidase activityLTA4H;NPEPL1;ERAP2;RNPEP;Ctsl;ERAP1;XPNPEP1;DPP9;TRHDE
carboxypeptidase activityCNDP1;PGCP;NAALADL1;CPB1;CPA2;CPM;CPD;ACE;BLMH
cysteine-type endopeptidase activityCFLARA;USP24;UCHL1;Casp3;USP34;USP12A;USP49;CTSF;CTSSA
cysteine-type peptidase activityCAPN2;FAM49BA;SENP3A;ESPL1;CLCA3;USP43A;CTSLA;CLCA5;CTSK
protein bindingNXT2;TLE3;FAM131C;EDNRB;YY1AP1;IMP3;SLC5A1;NBR1;SHC4

BLMH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BLMH here. Most of them are supplied by our site. Hope this information will be useful for your research of BLMH.

WDYHV1; NUDT12; APP; Fam134a; USP53; PDPK1; TRIO; CYP2C8; KBTBD7; ECSIT; RNF32; MAST1; Ckap5

Li, B; Zheng, YB; et al. Preparation and Evaluation of a CD13/APN-Targeting and Hydrolase-Resistant Conjugate that Comprises Pingyangmycin and NGR Motif-Integrated Apoprotein. JOURNAL OF PHARMACEUTICAL SCIENCES 103:1204-1213(2014).
Lafon-Hughes, L; Di Tomaso, MV; et al. Preferential localization of gamma H2AX foci in euchromatin of retina rod cells after DNA damage induction. CHROMOSOME RESEARCH 21:789-803(2013).
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