bax
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  • Official Full Name
  • BCL2-associated X protein
  • Background
  • This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described.
  • Synonyms
  • BAX; bcl2-L-4; BCL2L4; Bcl2-L-4; BCL2-associated X protein; Bcl-2-associated X protein; Apoptosis regulator BAX; apoptosis regulator BAX; Bcl-2-like protein 4; bcl-2-like protein 4; OTTHUMP00000218291; OTTHUMP00000218292; OTTHUMP00000218293; OTTHUMP00000218294; OTTHUMP00000218295; OTTHUMP00000218296
Cat.#:Bax-1381MTag:GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse BCL2-associated X Protein, GST-tagged
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Cat.#:Bax-244MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse BCL2-associated X Protein
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Cat.#:BAX-094HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human BAX Protein, GST-tagged
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Cat.#:BAX-095HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human BAX Protein, GST-tagged
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Cat.#:BAX-10147HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BAX, GST-tagged
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Cat.#:BAX-26650THTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BAX protein, GST-tagged
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Cat.#:BAX-458HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human BAX
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Cat.#:BAX-6975HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BAX, GST-tagged
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Cat.#:BAX-6976HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BAX, His-tagged
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Cat.#:BAX-2300MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse BAX Protein
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Cat.#:BAX-514RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey BAX Protein, His-tagged
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Cat.#:BAX-321HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BCL2-Associated X Protein, GST-tagged
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Cat.#:BAX-8506HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human BAX 293 Cell Lysate
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Bax Related Articles

Beers, K; Ferguson, J; et al. Comparison of the RAPID-B-(R) flow cytometer and the BAX((R)) system for the detection of non-0157 shiga toxin-producing Escherichia coli (STEC) in beef products. FOOD CONTROL 50:72-75(2015).
Gurzu, S; Kadar, Z; et al. Gastric cancer in young vs old Romanian patients: immunoprofile with emphasis on maspin and mena protein reactivity. APMIS 123:223-233(2015).

Bax Related Gene Family

BCL2 Gene Family