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Bfsp2

Official Full Name

beaded filament structural protein 2, phakinin
Overview

Phakinin is a protein that in humans is encoded by the BFSP2 gene. More than 99% of the vertebrate ocular lens consists of terminally differentiated lens fiber cells. Two lens-specific intermediate filament-like proteins, the protein product of this gene (CP49 or phakinin) and filensin (also known as CP115), are expressed only after fiber cell differentiation has begun. Both proteins are found in a structurally unique cytoskeletal element that is referred to as the beaded filament (BF). Mutations in this gene have been associated with juvenile-onset, progressive cataracts and Dowling-Meara epidermolysis bullosa simplex.
Synonyms

BFSP2; beaded filament structural protein 2, phakinin; CP47; CP49; LIFL-L; Phakinin; 49 kDa cytoskeletal protein; beaded filament protein CP49; bfps2, Cytoskeletal protein, 49-kD; lens intermediate filament-like light; lens fiber cell beaded filament protein CP 47; lens fiber cell beaded filament protein CP 49; MGC142078; MGC142080; OTTHUMP00000216298; PHAKOSIN;

Type

Cell & Tissue Lysates
Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Zebrafish

Source

HEK293
HEK293T
Mammalian Cell

Tag

His
His (Fc)
Avi
Myc
DDK
MYC
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	BFSP2-8461HCL	Recombinant Human BFSP2 293 Cell Lysate	HEK293	N/A	Inquiry
Human	BFSP2-1494H	Recombinant Human BFSP2 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK	Inquiry
Mouse	BFSP2-2389M	Recombinant Mouse BFSP2 Protein	Mammalian Cell	His	Inquiry
Mouse	BFSP2-1022M	Recombinant Mouse BFSP2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Mouse	BFSP2-1022M-B	Recombinant Mouse BFSP2 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Mouse	Bfsp2-351M	Recombinant Mouse Bfsp2 Protein, MYC/DDK-tagged	HEK293T	MYC/DDK	Inquiry
Zebrafish	BFSP2-1922Z	Recombinant Zebrafish BFSP2	Mammalian Cell	His	Inquiry
Chicken	BFSP2-6771C	Recombinant Chicken BFSP2	Mammalian Cell	His	Inquiry

Involved Pathway
Protein Function
Interacting Protein

Bfsp2 involved in several pathways and played different roles in them. We selected most pathways Bfsp2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with Bfsp2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

Bfsp2 has several biochemical functions, for example, protein binding, structural constituent of cytoskeleton, structural constituent of eye lens. Some of the functions are cooperated with other proteins, some of the functions could acted by Bfsp2 itself. We selected most functions Bfsp2 had, and list some proteins which have the same functions with Bfsp2. You can find most of the proteins on our site.

Function	Related Protein
protein binding	UFD1L;CTDSP2;CLSTN2;MALL;RAN;FAM40A;RNF5;KIF14;ERP44
structural constituent of cytoskeleton	DES;HIP1;F-KER;TPM1;TUBB2;EPB41;MSN;TUBA8;NEFM
structural constituent of eye lens	CRYBB3;LIM2.2;VIM;LIM2.5;CRYAA;LIM2.3;CRYGC;HSPB6;CRYGD

Bfsp2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Bfsp2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Bfsp2.

SYCE1; ATF4; MBIP