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C3

  • Official Full Name

    complement component 3

  • Overview

    C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.
  • Synonyms

    complement C3; Acylation Stimulating Protein Cleavage Product; ASP; C3 and PZP like alpha 2 macroglobulin domain containing protein 1; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1; C3; CO3_HUMAN; Complement C3 precursor; Complement C3c alpha'' chain fragment 2; Complement Component 3; Complement factor 3; CPAMD 1; CPAMD1;

  • Recombinant Proteins
  • Native Proteins
  • Transfected Stable Cell Lines
  • Protein Pre-coupled Magnetic Beads
  • Bovine
  • C. botulinum
  • Cattle
  • Chicken
  • Clostridium botulinum D bacteriophage
  • Cynomolgus
  • Human
  • Monkey
  • Mouse
  • Pig
  • Rabbit
  • Rat
  • Swine
  • C. botulinum
  • Clostridium botulinum D bacteriophage
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • Human Plasma
  • Human serum
  • Human Serum
  • Mammalian Cell
  • Mammalian cells
  • Normal cynomolgus serum from healthy animals of mixed gender
  • Normal mouse serum from healthy animals of mixed gender
  • Normal rabbit serum from healthy animals of mixed gender
  • Normal rat serum from healthy animals of mixed gender
  • Plasma
  • Yeast
  • C
  • His
  • Flag
  • His (Fc)
  • Avi
  • His|GST
  • His|T7
  • SUMO
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
  • N
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human C3-603H Active Recombinant Human C3 E.coli N/A
Human C3-365H Active Native Human C3 Protein Human Serum N/A
Human C3-01H Active Recombinant Human C3 Protein E.coli N/A
Human C3-7631H Recombinant Human C3 protein, His-tagged E.coli His Glu1322~Cys1661
Human C3-558H Recombinant Human C3 Protein, His/GST-tagged E.coli His/GST Ser672~Arg748
Human C3-10522H Recombinant Human C3, His-tagged E.coli His C-term-350a.a.
Human C3-7842H Recombinant Human C3 protein, His-tagged E.coli His Leu1000~Glu1326
Human C3-1149H Recombinant Human C3 Protein, His-tagged E.coli His
Human C3-7H Active Human C3 Reference Standard N/A
Human C3-10H Active Recombinant Human C3 protein, His-tagged HEK293 His Ser 23 - Asn 1663
Human C3-1841H Recombinant Human C3 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human C3-365HFL Recombinant Full Length Human C3 Protein, C-Flag-tagged Mammalian cells Flag
Human C3-8391H Native Human C3 Plasma N/A
Human C3-012H Native Human Complement C3c Human serum
Human C3-3052H Recombinant Human C3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human C3-1859H Active Recombinant Human C3 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Ser 23 - Asn 1663
Human C3-471H Recombinant Human C3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human C3-2505H Recombinant Human C3 protein(961-1040 aa), C-His-tagged E. coli C-His 961-1040 aa
Human C3-471H-B Recombinant Human C3 Protein Pre-coupled Magnetic Beads HEK293
Human C3-194H Native Human Complement C3c Human Plasma N/A
Human C3-2212H Recombinant Human C3 Protein (Ser672-Arg748) E.coli Tag Free Ser672-Arg748
Human C3-8092H Native Human Plasma COMPLEMENT C (C3) Human Plasma N/A
Mouse C3-7843M Recombinant Mouse C3 protein, His-tagged E.coli His Glu1314~Asn1663 (Accession # P01027)
Mouse C3-559M Recombinant Mouse C3 Protein, His/GST-tagged E.coli His/GST Ser671~Arg748
Mouse C3-7632M Recombinant Mouse C3 protein, His-tagged E.coli His Ala965-Arg1303
Mouse C3-732M Recombinant Mouse C3 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse C3-05M Native Mouse C3 Protein Normal mouse serum from healthy animals of mixed gender
Mouse C3-1944M Recombinant Mouse C3 protein, His-tagged HEK293 His Ile 25 - Asn 1663
Mouse C3-4246M Recombinant Mouse C3 protein, His-SUMO-tagged E.coli His-SUMO 1321-1663aa
Mouse C3-33M Mouse C3 Reference Standard N/A
Rat C3-7845R Recombinant Rat C3 protein, His-tagged E.coli His Asp966~Trp1313 (Accession # P01026)
Rat C3-561R Recombinant Rat C3 Protein, His/GST-tagged E.coli His/GST Ser671~Arg748
Rat C3-1050R Recombinant Rat C3 Protein Mammalian Cell His
Rat C3-708R Recombinant Rat C3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat C3-5695R Recombinant Rat C3 protein, His-tagged Yeast His 671-746aa
Rat C3-73R Rat C3 Reference Standard N/A
Rat C3-08R Native Rat C3 Protein Normal rat serum from healthy animals of mixed gender
Rat C3-708R-B Recombinant Rat C3 Protein Pre-coupled Magnetic Beads HEK293
Monkey C3-02M Native Monkey C3 Protein Normal cynomolgus serum from healthy animals of mixed gender
Rabbit C3-01R Native Rabbit C3 Protein Normal rabbit serum from healthy animals of mixed gender
Rabbit C3-4324R Recombinant Rabbit C3 Protein Yeast N/A 77aa
Bovine C3-4464B Recombinant Bovine C3 protein, His-SUMO-tagged E.coli His-SUMO 747-953aa
C. botulinum C3-001C Active Native C. botulinum C3 Enzyme C. botulinum N/A
Cattle C3-338C Recombinant Cattle C3 Protein, His-tagged E.coli N-His Gly448-Thr665
Clostridium botulinum D bacteriophage C3-147C Active Native Botulinum C3 Enzyme Clostridium botulinum D bacteriophage N/A
Cynomolgus C3-114C Active Recombinant Cynomolgus C3 protein, His-tagged HEK293 His Thr 23 - Asn 1663
Swine C3-4325S Recombinant Swine C3 Protein Yeast N/A 77aa
Pig C3-560P Recombinant Pig C3 Protein, His/GST-tagged E.coli His/GST Ser670~Leu742
Pig C3-7844P Recombinant Pig C3 protein, His & T7-tagged E.coli His/T7 Asp23~Thr300 (Accession# P01025)
Chicken C3-6956C Recombinant Chicken C3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • C3 Related Articles
  • C3 Related Research Area

C3 involved in several pathways and played different roles in them. We selected most pathways C3 participated on our site, such as Phagosome, Complement and coagulation cascades, Pertussis, which may be useful for your reference. Also, other proteins which involved in the same pathway with C3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
PhagosomeTUBA3D;C3A.1;SFTPA1;HLA-DMB;ATP6V0A4;FCGR2C;COLEC12;TUBA1C;C1R
Complement and coagulation cascadesSERPINA5;C5;F8;PLAUR;C3;MASP2;F9;F7;C8A
PertussisIRAK1;CALML5;CALM4;C1QC;IRF8;MAPK12;ITGB1;Casp3;PYCARD
LegionellosisCYCS;BCL2L13;IL18;EEF1G;RELA;CD14;NLRC4;HSPA1L;HSPD1
LeishmaniasisELK1;IFNGR1;TGFB1;HLA-DOA;H2-AA;HLA-DMB;NCF4;IFNG;HLA-DPA1
Chagas disease (American trypanosomiasis)IL12A;CD3E; CD3D;CD3E;GNAO1;MAPK12;PLCB4;C3;MAPK10;IKBKG
Staphylococcus aureus infectionFCGR3B;CFI;FCGR4;FCGR2A;FCGR1;C3;HLA-DRA;HLA-DRB5;PLG
TuberculosisCALM2;IRAK1;IL10RB;PPP3CC;IFNA8;CORO1A;NFYC;CAMK2A;CEBPG
Herpes simplex infectionPER1B;TNFRSF14;SKP2;Hc;IL12BA;USP7;SRSF9;GTF2I;POLR2A
Viral carcinogenesisGTF2H2C;SP100;RB1;HIST1H2BH;MAPK1;TTC6;YWHAG;PIK3CD;MDM2
Systemic lupus erythematosusSNRPB;H2AFB1;H2AFJ;HIST1H2AJ;HIST1H2BA;Hc;H2AFZ;IFNG;GM14479

C3 has several biochemical functions, for example, C5L2 anaphylatoxin chemotactic receptor binding, cofactor binding, endopeptidase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by C3 itself. We selected most functions C3 had, and list some proteins which have the same functions with C3. You can find most of the proteins on our site.

Function Related Protein
C5L2 anaphylatoxin chemotactic receptor binding
cofactor bindingC3;WWOX;DAO;HACL1;TYMS;UROS;ACLY;DDO;HIF1AN
endopeptidase inhibitor activitySerpina1c;STFA2;MUG2;PSMF1;PI3;STFA1;C3B.2;A2ML;SLPI
lipid bindingPITPNM3;STARD6;CHMP4A;MAL;ACOT11;ALOX8;FABP1A;ACBD6;CYP21A1
protein bindingNSMCE1;AKAP17A;DEPDC1;NSF;BTRC;VPS37A;FRMD7;GATSL3;FNTA
receptor bindingGSTK1;FLT3LG;MPV17L;PTK6B;CADM2;LRRC4B;TAC4;HILPDA;GFRA3

C3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with C3 here. Most of them are supplied by our site. Hope this information will be useful for your research of C3.

VSIG4; VSIG4; CD46; d3jib2_staau; IGM; VHL; ASF1B; TGM2; q99ib8-pro_0000045598; q99ib8-pro_0000045601; d-mannose; crlkekhc; IGHM

Ohta, T; Urayama, K; et al. Eculizumab in the treatment of atypical hemolytic uremic syndrome in an infant leads to cessation of peritoneal dialysis and improvement of severe hypertension. PEDIATRIC NEPHROLOGY 30:603-608(2015).
Yue, PJ; He, L; et al. Long-term toxicity study of rAd5-hTERTC27 in SD rats and Cynomolgus monkeys by intravenous injection. REGULATORY TOXICOLOGY AND PHARMACOLOGY 71:285-294(2015).
  • Q&As
  • Reviews

Q&As (6)

Ask a question
Have proteins been found to interact with C3 proteins? 10/26/2019

Yes, a variety of proteins that interact with C3 proteins, including complement receptors, regulatory proteins, inflammatory factors, etc., have been discovered, and they are jointly involved in the regulation and functional execution of C3 proteins.

What is the relationship between C3 protein and infectious diseases? 09/28/2019

C3 protein plays an important role in infectious diseases. It can play an anti-infection role by activating the complement system, directly killing pathogens or enhancing the ability of immune cells to destroy pathogens.

How is the research progress of C3 protein at present? 09/23/2019

Research on C3 protein is going on. At present, it mainly focuses on the analysis of its function and regulatory mechanism, the identification of gene mutations associated with diseases, and the interaction with other complement proteins and immune cells, which provides a theoretical basis for the further development of diagnosis and treatment methods of related diseases.

What is the use of C3 protein in laboratory diagnostics? 05/24/2019

C3 protein can be used as an aid in the diagnosis of certain immune-related diseases. Measuring the level of C3 protein in serum can reflect the activity of the immune system and the degree of inflammation.

What are the effects of post-translational modifications of C3 protein on its function? 04/15/2019

Post-translational modifications of the C3 protein can affect its function. Phosphorylation, cleavage, methylation and other modifications can regulate the activity, stability and interaction ability of C3 proteins.

Have any drug treatments associated with C3 protein been identified? 02/22/2019

Yes, some C3 protein-related drug treatments are under development, including drugs that regulate the degree of C3 protein activation, drugs that inhibit the overactivation of C3 protein, etc.

Customer Reviews (3)

Write a review
Reviews
02/23/2022

    Expression efficiency is high. In our experiments, we found that the target protein can be synthesized quickly and effectively.

    01/26/2022

      Activity was not significantly different from the native protein, as expected.

      03/23/2021

        High purity, no obvious impurities.

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