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CALR

  • Official Full Name

    calreticulin

  • Overview

    Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. Calreticulin can inhibit the binding of androgen receptor to its hormone-responsive DNA element and can inhibit androgen receptor and retinoic acid receptor transcriptional activities in vivo, as well as retinoic acid-induced neuronal differentiation. Thus, calreticulin can act as an important modulator of the regulation of gene transcription by nuclear hormone receptors. Systemic lupus erythematosus is associated with increased autoantibody titers against calreticulin but calreticulin is not a Ro/SS-A antigen. Earlier papers referred to calreticulin as an Ro/SS-A antigen but this was later disproven. Increased autoantibody titer against human calreticulin is found in infants with complete congenital heart block of both the IgG and IgM classes. [provided by RefSeq, Jul 2008]
  • Synonyms

    CALR; calreticulin; RO; CRT; SSA; cC1qR; HEL-S-99n; CRP55; ERp60; HACBP; grp60; calregulin; endoplasmic reticulum resident protein 60; epididymis secretory sperm binding protein Li 99n; Sicca syndrome antigen A (autoantigen Ro; calreticulin);

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chinese hamster
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Pig
  • Rabbit
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • Confidential
  • E. coli
  • E.coli
  • HEK293
  • HEK293F
  • HEK293T
  • Human Cell
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Yeast
  • C
  • His
  • Fc
  • Flag
  • GST
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
  • N
  • SKIK
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CALR-2368H Recombinant Human Calreticulin, 18-417 aa, His-tagged E.coli His
Human CALR-8593H Recombinant Human CALR, Fc tagged HEK293 Fc Met1-Ala413
Human CALR-906H Recombinant Human Calreticulin, His-tagged E.coli His
Human CALR-27213TH Recombinant Human CALR E.coli N/A
Human CALR-0313H Recombinant Human CALR Protein, GST-Tagged Wheat Germ GST
Human CALR-8594H Recombinant Human CALR protein, His-tagged HEK293 His Met1-Ala413
Human CALR-27212TH Recombinant Human CALR, His-tagged E.coli His
Human CALR-524H Recombinant Human CALR protein, His-tagged HEK293F His
Human CALR-1222HCL Recombinant Human CALR cell lysate Human Cell N/A
Human CALR-2288H Recombinant Human CALR Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human CALR-06H Recombinant Human CALR Protein E.coli
Human CALR-2764H Recombinant Human CALR Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CALR-90HFL Recombinant Full Length Human CALR Protein, C-Flag-tagged Mammalian cells Flag
Human CALR-301231H Recombinant Human CALR protein, GST-tagged E.coli GST Lys248-Leu417
Human CALR-488H Recombinant Human CALR Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CALR-2625H Recombinant Human CALR protein, GST-tagged E.coli GST 18-417aa
Human CALR-488H-B Recombinant Human CALR Protein Pre-coupled Magnetic Beads HEK293
Human CALR-0216H Recombinant Human CALR Protein, Tag Free Confidential Tag Free
Human CALR-5193H Recombinant Human CALR Protein (Met1-Ala413), C-His tagged Mammalian cells C-His Met1-Ala413
Human CALR-3078HF Recombinant Full Length Human CALR Protein, GST-tagged In Vitro Cell Free System GST 417 amino acids
Human CALR-0821H Recombinant Human CALR Protein (Glu18-Pro204), N-His tagged E.coli N-His Glu18-Pro204
Human CALR-2706H Recombinant Human CALR protein(91-230 aa), C-His-tagged E. coli C-His 91-230 aa
Mouse Calr-7034M Recombinant Mouse Calr protein, His-tagged E.coli His Asp199~Tyr308
Mouse Calr-1185M Recombinant Mouse Calreticulin E.coli N/A
Mouse Calr-356M Recombinant Mouse Calr Protein, His-tagged E.coli N-His Pro19-Leu416
Mouse CALR-377M Recombinant Mouse CALR Protein (18-416 aa), GST-tagged E.coli GST 18-416 aa
Mouse Calr-748M Recombinant Mouse Calr Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse Calr-5359M Recombinant Mouse Calr protein, His-tagged Yeast His 18-416aa
Mouse Calr-1438M Recombinant Mouse Calr protein, SKIK-His-tagged Yeast SKIK-His 18-416aa
Rat CALR-1097R Recombinant Rat CALR Protein Mammalian Cell His
Rat CALR-761R Recombinant Rat CALR Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Calr-357R Recombinant Rat Calr Protein, His-tagged E.coli N-His Ala72-Lys322
Rat CALR-761R-B Recombinant Rat CALR Protein Pre-coupled Magnetic Beads HEK293
Rabbit CALR-2073R Recombinant Rabbit Calreticulin E.coli N/A
Chinese hamster CALR-1433C Recombinant Chinese hamster CALR protein, His-tagged Yeast His 18-417aa
Cynomolgus Monkey CALR-356C Recombinant Cynomolgus CALR Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey CALR-104C-B Recombinant Cynomolgus Monkey CALR Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey CALR-104C Recombinant Cynomolgus Monkey CALR Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque CALR-610R Recombinant Rhesus monkey CALR Protein, His-tagged Mammalian Cell His
Rhesus Macaque CALR-438R Recombinant Rhesus Macaque CALR Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque CALR-438R-B Recombinant Rhesus Macaque CALR Protein Pre-coupled Magnetic Beads HEK293
Zebrafish CALR-8675Z Recombinant Zebrafish CALR Mammalian Cell His
Pig CALR-2130P Recombinant Pig CALR Protein (18-417 aa), His-tagged Yeast His 18-417 aa
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CALR Related Articles
  • CALR Related Research Area

CALR involved in several pathways and played different roles in them. We selected most pathways CALR participated on our site, such as Protein processing in endoplasmic reticulum, Phagosome, Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with CALR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Protein processing in endoplasmic reticulumRAD23AA;SAR1B;NGLY1;MAN1A;HSP90AA1;CUL1;ATF6;MAN1C1;CALRL2
PhagosomeHLA-DQA1;RAB5AA;NCF1;DYNC1I2A;ITGB1;ATP6V1E2;ACTB1;CANX;BF2
Antigen processing and presentationKLRC3;RFXANK;TAP2;HLA-A;HLA-DPB1;HLA-C;HSP90AB1;HLA-F;LGMN
Chagas disease (American trypanosomiasis)ACE;SERPINE1;CD3D;GNAO1;PIK3R2;C3;PIK3R1;NFKBIA;GNAI3
HTLV-I infectionCD3E;CD3D;WNT3A;TGFBR1;IL1R1;HLA-DMA;KAT2B;ITGAL;IL15

CALR has several biochemical functions, for example, DNA binding, androgen receptor binding, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CALR itself. We selected most functions CALR had, and list some proteins which have the same functions with CALR. You can find most of the proteins on our site.

Function Related Protein
DNA bindingTIGD2;LUC7L3;HOXB6B;PIAS1;KLF14;IRF6;PPARDB;ERG;ZFP574
androgen receptor bindingNCOA3;CTNNB1;DDX5;PRPF6;RAN;GRIP1;PRKCB;FHL2;PKN1
calcium ion bindingPCDHGA8;EHD1A;SYT17;ACTN2;FLG2;SPARCL1;LTBP1;PCDHGA12;PCDH2G12
carbohydrate bindingLGALS2A;CLEC4M;CLEC4A;CLEC4D;SORD;GALNT14;Chil3;GALNTL4;CD302
chaperone bindingBAG4;DNAJA1;TRP53;SDF2L1;DLST;DNLZ;CP;PARK2;DNAJA2L
complement component C1q bindingC1QBP;C4A;CRP;CD93;PTX3;APCS;CALR
glycoprotein bindingTFRC;Shh;VLDLR;Serpina1b;CANX;OS9;FBXO17;CDH1;FOXRED2
hormone bindingCRYM;ADIPOR2;MC1R;UCN2;CALR;TTR;AMHR2;NPR3;NPR1
integrin bindingESM1;EMP2;COL3A1;COL4A3;WISP1A;LYN;FERMT3;VCAM1;FAP
iron ion bindingCYP46A1.2;CYP2C8;HBD;TPH1;CYP4A10;HIF1AN;HBB-B2;CYP46A1;FDX1
mRNA bindingG3BP1;RPL7;CPSF6;HNRPLL;DCP1B;SOSTDC1B;RPS26L;RPS2;QKI
peptide bindingGNRHR;CALR;ERAP1;CTSL2;Npepo;AVPR2;AVPR2L;ERCC3;ERAP2
poly(A) RNA bindingBCLAF1;GM5506;EDF1;RPL5;RPL10A;P4HB;AGO2;PPHLN1;POLR2A
protein bindingCSTF3;MSH4;HSPB6;HTR3E;ITGA7;TSC2;SOCS3;METTL17;KLKB1
protein binding involved in protein foldingHSPA1B;PFDN1;CD74;CLGN;PFDN2;PDCL3;CALR3;RIC3;DNAJB8
ubiquitin protein ligase bindingTANK;CALR;LTBR;PIAS1;CUL5A;TRAF5;PCBP2;MAGEA2;CKB
unfolded protein bindingPFDN2;HSPA6;HSP90AA1;GRPEL1;HSP26;HSP90AA1.2;DNAJA2L;SIL1;ERLEC1
zinc ion bindingZGLP1;CSRP1;RBM4.2;MAN2B1;LRSAM1;BRCA1;DNMT1;MARCH5L;SIAH1

CALR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CALR here. Most of them are supplied by our site. Hope this information will be useful for your research of CALR.

GABARAP; APP; HSPB1; TAP1; p29991-pro_0000037946; env; EIF1B; F8; EPB41; CD40

Wilhelm, M; Lawrence, JJ; et al. Enteric plexuses of two choline-acetyltransferase transgenic mouse lines: Chemical neuroanatomy of the fluorescent protein-expressing nerve cells. BRAIN RESEARCH BULLETIN 111:76-83(2015).
Vannucchi, AM; Rotunno, G; et al. Calreticulin mutation-specific immunostaining in myeloproliferative neoplasms: pathogenetic insight and diagnostic value. LEUKEMIA 28:1811-1818(2014).
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