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CDC6

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Official Full Name
cell division cycle 6 homolog
Background
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the;initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It;localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The;subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks.;Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional;control mechanism involving E2F proteins.
Synonyms
CDC6; cell division cycle 6 homolog (S. cerevisiae); CDC6 (cell division cycle 6, S. cerevisiae) homolog , CDC6 cell division cycle 6 homolog (S. cerevisiae) , CDC18L; cell division control protein 6 homolog; p62(cdc6); CDC6-related protein; cdc18-relate
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CDC6 Related Articles
>> Di Paola, D; Rampakakis, E; et al. Increased origin activity in transformed versus normal cells: identification of novel protein players involved in DNA replication and cellular transformation. NUCLEIC ACIDS RESEARCH 38:2314-2331(2010).
>> Buechler, S; et al. Low expression of a few genes indicates good prognosis in estrogen receptor positive breast cancer. BMC CANCER 9:-(2009).

45-1 Ramsey Road, Shirley, NY 11967, USA
USA: 1-631-559-9269  1-631-448-7888
Europe: 44-207-048-3343
FAX: 1-631-938-8127
EMAIL: info@creative-biomart.com

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