CHEK1
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Official Full Name
checkpoint kinase 1
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Overview
The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011] -
Synonyms
CHEK1; checkpoint kinase 1; CHK1; serine/threonine-protein kinase Chk1; Chk1-S; checkpoint kinase-1; CHK1 checkpoint homolog; cell cycle checkpoint kinase; Checkpoint, S. pombe, homolog of, 1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Insect (sf21)
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Sf21
- Sf9 Insect Cell
- Wheat Germ
- DDK
- Flag
- GST
- GST|His
- His
- His (Fc)
- Avi
- His|T7
- MYC
- Myc|DDK
- N/A
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
CHEK1 involved in several pathways and played different roles in them. We selected most pathways CHEK1 participated on our site, such as Activation of ATR in response to replication stress, Cell Cycle, Cell Cycle Checkpoints, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHEK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Activation of ATR in response to replication stress | CHEK1;CLSPN;RAD17;RAD1;RAD9;MCM10;RAD9A;DBF4;CDK2 |
| Cell Cycle | KIF2C;ANAPC7;UBE2V2;CDC23;MYCB;CTDNEP1;ORC3;NEK7;SSNA1 |
| Cell Cycle Checkpoints | KAT5;UBE2V2;UIMC1;BABAM1;BARD1;HTATIP;CDKN1B;MCM10;MCM8 |
| Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | |
| Circadian rhythm pathway | CHEK1;NONO;DEC1;TIMELESS |
| DNA Double-Strand Break Repair | RAD9A;CHEK1;HUS1;RNF168;RAD51AP1;DNA2;FUZ;PPP4R2B;PARP1 |
| DNA Repair | COPS6;NFRKB;UBE2L6;INO80;ZFP830;KIAA0101;DNA2;ALKBH2;CHEK1 |
CHEK1 has several biochemical functions, for example, ATP binding, histone kinase activity (H3-T11 specific), protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CHEK1 itself. We selected most functions CHEK1 had, and list some proteins which have the same functions with CHEK1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | NUBPL;INSRB;Acsm2a;ZNF143B;PIP5K1B;MYO10;PKN2;CHKA;PKN3 |
| histone kinase activity (H3-T11 specific) | PKN1;CHEK1 |
| protein binding | HELLS;CCAR1;ANKMY2;FBXW8;DCAF8;APBA3;SYT2;OSTB;EIF3B |
| protein kinase activity | POMK;NRBP1;SYK;TBRG4;IKBKB;GC3;PRKAG1;SBK3;MAP3K12 |
| protein serine/threonine kinase activity | STK38L;KSR2;STK39;NEK5;TTBK1;PRKG1A;cka1;STK17A;RIOK3 |
CHEK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHEK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CHEK1.
HSP90AB1; N/A; CDC25C; SMURF1; YWHAG
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