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COL4A3

  • Official Full Name

    collagen, type IV, alpha 3 (Goodpasture antigen)

  • Overview

    Type IV collagen, the major structural component of basement membranes, is a multimeric protein composed of 3 alpha subunits. These subunits are encoded by 6 different genes, alpha 1 through alpha 6, each of which can form a triple helix structure with 2 other subunits to form type IV collagen. This gene encodes alpha 3. In the Goodpasture syndrome, autoantibodies bind to the collagen molecules in the basement membranes of alveoli and glomeruli. The epitopes that elicit these autoantibodies are localized largely to the non-collagenous C-terminal domain of the protein. A specific kinase phosphorylates amino acids in this same C-terminal region and the expression of this kinase is upregulated during pathogenesis. This gene is also linked to an autosomal recessive form of Alport syndrome. The mutations contributing to this syndrome are also located within the exons that encode this C-terminal region. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter.
  • Synonyms

    COL4A3; collagen, type IV, alpha 3 (Goodpasture antigen); collagen alpha-3(IV) chain; tumstatin; collagen IV, alpha-3 polypeptide;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Cell & Tissue Lysates
  • Bovine
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • Human Cell
  • Mammalian Cell
  • Sf9 Insect Cell
  • His
  • His (Fc)
  • Avi
  • His|GST
  • N/A
  • N
  • GST
  • hFc
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human COL4A3-179H Recombinant Human COL4A3 Mammalian Cell His
Human COL4A3-1369H Recombinant Human COL4A3, His-tagged Sf9 Insect Cell His
Human COL4A3-2714H Recombinant Human COL4A3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human COL4A3-2715H Recombinant Human COL4A3 protein, His-tagged E.coli His 1427-1668aa
Human COL4A3-334H Recombinant Human COL4A3 Protein, His/GST-tagged E.coli His/GST Leu1428~His1670
Human COL4A3-2714H-B Recombinant Human COL4A3 Protein Pre-coupled Magnetic Beads HEK293
Human COL4A3-1766H Recombinant Human COL4A3 Protein (Leu1428-His1670), N-GST tagged E.coli N-GST Leu1428-His1670
Mouse COL4A3-3737M Recombinant Mouse COL4A3 Protein Mammalian Cell His
Mouse COL4A3-1864M-B Recombinant Mouse COL4A3 Protein Pre-coupled Magnetic Beads HEK293
Mouse COL4A3-1864M Recombinant Mouse COL4A3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Col4a3-8807R Recombinant Rat Col4a3 protein(Gly1426-His1670), hFc-tagged HEK293 N-hFc Gly1426-His1670
Rat COL4A3-1219RCL Recombinant Rat COL4A3 cell lysate Human Cell N/A
Bovine COL4A3-1132B Recombinant Bovine COL4A3 protein, His-tagged E.coli His 234-471aa
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • COL4A3 Related Articles
  • COL4A3 Related Research Area

COL4A3 involved in several pathways and played different roles in them. We selected most pathways COL4A3 participated on our site, such as Amoebiasis, Assembly of collagen fibrils and other multimeric structures, Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with COL4A3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
AmoebiasisAASS;IFNG;SERPINB4;ARG2;Casp3;LAMB2;NOS2;COL1A2;SERPINB1C
Assembly of collagen fibrils and other multimeric structuresCOL1A1;COL10A1A;COL6A3;COL4A4;COL10A1;COL6A2;LOXL3;COL5A3A;BMP1B
Axon guidanceNRP1A;NFATC2;CSK;KCNQ2;ROCK1;RHOAE;COL9A1;CFL1;SCN4A
Collagen biosynthesis and modifying enzymesPRP;COL17A1A;COL9A1;P3H2;COL28A1D;COL10A1;ADAMTS3;LEPREL1;SERPINH1B
Collagen formationSERPINH1A;COL9A1B;LOXL3;COL17A1A;TLL2;COL3A1;PCOLCEA;COL9A3;BMP1A
Developmental BiologyLGI1B;MED21;NKX2.2A;MYOD1;AP2A2;AP2B1;TRPC3;EZRA;PEBP1
ECM-receptor interactionCD47;SPP1;VTN;COL24A1;SV2C;LAMB1A;ITGA3;ITGA10;LAMB1
Extracellular matrix organizationMFAP1B;LOXL2;COL8A1A;EFEMP1;MGC174152;F11R.2;BGNA;CTSB;EFEMP2

COL4A3 has several biochemical functions, for example, extracellular matrix structural constituent, integrin binding, metalloendopeptidase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by COL4A3 itself. We selected most functions COL4A3 had, and list some proteins which have the same functions with COL4A3. You can find most of the proteins on our site.

Function Related Protein
extracellular matrix structural constituentCOL1A2;LAMA1;PRELP;MUC5AC;COL4A6;COL24A1;LAMB1;LAMC1;COL11A1B
integrin bindingTHY1;CYR61;LAMB1;LAMA5;CD151;SRC;ITGB5;FN1A;CYR61L1
metalloendopeptidase inhibitor activityTIMP2A;WFIKKN2;SPOCK1;TIMP1;LXN;BST2;TIMP2;FETUB;NGF
protein bindingKEAP1;PARK2;POT1;SARM1;EHMT2;TMEM100;ANO2;GSN;LRRC75A-AS1
structural molecule activityKRT73;LCE4A;CLDN11B;CLDNC;CLDNF;MTAP7D2;KRT86;CLDN11;CLDN10

COL4A3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COL4A3 here. Most of them are supplied by our site. Hope this information will be useful for your research of COL4A3.

KLK6

Yao, XD; Chen, X; et al. Challenge in pathologic diagnosis of Alport syndrome: evidence from correction of previous misdiagnosis. ORPHANET JOURNAL OF RARE DISEASES 7:-(2012).
Abrahamson, DR; Hudson, BG; et al. Cellular Origins of Type IV Collagen Networks in Developing Glomeruli. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 20:1471-1479(2009).
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