CTNNB1
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Official Full Name
catenin (cadherin-associated protein), beta 1, 88kDa
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Overview
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Oct 2009] -
Synonyms
CTNNB1; catenin (cadherin-associated protein), beta 1, 88kDa; CTNNB; MRD19; armadillo; catenin beta-1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Canis Lupus Familiaris (Dog)
- Chicken
- Dog
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- Baculovirus-Insect Cells
- E. coli
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Insect Cell
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- Mammalian cells
- Sf9 Insect Cell
- Wheat Germ
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- C
- His
- DDK
- Flag
- GST
- His (Fc)
- Avi
- His|GST
- Myc
- MYC
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- CTNNB1 Related Articles
- CTNNB1 Related Research Area
- CTNNB1 Related Signal Pathway
CTNNB1 involved in several pathways and played different roles in them. We selected most pathways CTNNB1 participated on our site, such as Adherens junction, Adherens junctions interactions, Adipogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CTNNB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Adherens junction | PVRL4;MLLT4;ACTB2;SNAI2;WASF3B;INSR;SMAD3;NLK;CSNK2A2A |
| Adherens junctions interactions | CDH6;CDH2;CTNND1;JUPA;PVRL2L;CDH24;CTNNB2;CDH7;CADM2B |
| Adipogenesis | BMP1;MEF2B;AGT;CTNNB1;STIL;PIANP;AGPAT2;E2F1;MIXL1 |
| Androgen receptor signaling pathway | MYST2;KAT5;PIAS3;KDM1A;RNF4;RHOB;TGFB1I1;RAD54L2;DAXX |
| Apoptosis | DIABLOB;HMGB2;NFKBIA;BIRC5A;NMT1;DFFA;PPP3R1B;PIK3R3;IRAK1 |
| Apoptotic cleavage of cell adhesion proteins | CTNNB2;PKP1;CTNNB1;OCLN;DSG2;PTBP3;DSG1;DSP;DSG3 |
| Apoptotic cleavage of cellular proteins | CASP6L1;DSG1;DSP;PTBP3;DBNL;PLECA;DSG2;PKP1;DSG3 |
| Apoptotic execution phase | CTNNB1;DNM1L;SATB1;DSP;DFFA;HIST1H1E;H1F0;DSG3;DBNL |
CTNNB1 has several biochemical functions, for example, I-SMAD binding, R-SMAD binding, RNA polymerase II activating transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CTNNB1 itself. We selected most functions CTNNB1 had, and list some proteins which have the same functions with CTNNB1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| I-SMAD binding | AXIN1;SMAD7;TGFB1I1;CTNNB1;TGFBR1;SMAD4;SMURF1;SMAD2;AXIN2 |
| R-SMAD binding | TRIM33;SMAD4;SMURF1;ZC3H3;ANKRD1;SMAD6;SMAD2;MEN1;PARP1 |
| RNA polymerase II activating transcription factor binding | PITX2;CREBBP;NHLH2;TBX6;LDB1;SIN3A;LMO2;JUN;SMAD3 |
| SMAD binding | SKI;SKIA;SKOR2;STUB1;CTNNB1;TCF12;USP15;SKOR1;SKIL |
| alpha-catenin binding | JUB;PKP2;CDH2;VCL;CDH24;PKP3;JUP;CTNNB1;AJUBA |
| androgen receptor binding | WIPI1;TCF21;NSD1;RNF14;TRIM68;CCNE1;KDM3A;DAXX;PIAS2 |
| cadherin binding | VCL;AKAP5;CTNNA3;CTNND1;OLFM4;PROM1;P2RX4;CD46;FXYD5 |
| double-stranded DNA binding | DDX58;TDG;XRCC2;NKX2-8;TDP1;DMC1;MTERF3;SP8B;HNRNPDL |
| enzyme binding | KDM4C;NOXO1;HSPA8;UGT1A6;RPS19BP1;LAMB1;LAMP1;TRIO;PRMT1 |
| estrogen receptor binding | MMS19;NKX3-1;CTNNB1;NSD1;ARRB1;PCNA;XBP1;CCDC62;STRN |
| euchromatin binding | ASH2L;CTNNB1 |
| ion channel binding | YWHAQ;CHERP;CAV1;GPD1L;SRI;CDH5;AKAP9;LRRK2;KCNH5 |
| kinase binding | SNAI1;PFKFB1;DLG4;C2orf44;MIDN;PER1;STX1A;HAP1;TOLLIP |
| nuclear hormone receptor binding | CRX;SNW1;TCF7L2;Ankar;BUD31;NCOA2;HIF1A;MYOD1;CTNNB1 |
| protein C-terminus binding | YWHAB;NIPBL;PQBP1;ZBTB16;CD2AP;CALCOCO1;SLC9A3R2;PXK;ARL6IP5 |
| protein binding | SKP1;BCL9;PSPC1;GRIN2B;RAB35;THAP8;DNER;TTC19;TRAF2 |
| protein phosphatase binding | PIK3R2;ROS1;PPARG;SNX3;FLT4;PPP6R1;SHOC2;ITGA1;AP3B1 |
| repressing transcription factor binding | PRDM5;NOC2L;EIF4E;HDAC7A;KAT5;SKI;HDAC1;MYC;TLE4 |
| signal transducer activity | PTK2AB;PTGER4C;CELSR1;GPR183B;MC5RB;VMN1R40;TAAR13E;CCR9A;OLFR24 |
| transcription coactivator activity | TAF9;BRCA1;MMS19;STIL;TRIM24;TAF11;SOX17;MAGED1;SMARCD1 |
| transcription factor activity, sequence-specific DNA binding | SMAD6;TCF25;DEAF1;TCF3;TBX16;KLF9;CRX;HSFY1;ZNF41 |
| transcription factor binding | JUNBB;SUMO1;HEY1;RBPJ;NLRP3;NCOR2;RNF4;CAMTA2;EP300 |
| transcription regulatory region DNA binding | HOXA13;ARID4A;NCOR1;HIVEP2;TAF7;GFI1;ATF5;TP63;TAF7L |
CTNNB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CTNNB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CTNNB1.
TCF7L2
- Q&As
- Reviews
Q&As (5)
Ask a questionYes, CTNNB1 is implicated in the development and progression of pancreatic cancer, with its dysregulated activity contributing to tumor growth, invasion, and metastasis.
Mutations in the CTNNB1 gene lead to the stabilization and accumulation of β-catenin, contributing to the development of HCC, making it a potential biomarker for the diagnosis and prognosis of HCC.
Studies have shown that CTNNB1 expression levels can serve as an independent prognostic factor in gastric cancer, with high CTNNB1 expression correlating with poor patient outcomes.
While there are no direct CTNNB1-targeted therapies available, various drugs targeting the Wnt signaling pathway are being developed and tested, which indirectly impact CTNNB1 activity in cancer cells.
High expression levels of CTNNB1 in breast cancer cells have been linked to poor prognosis and shorter overall survival, indicating its potential as a prognostic marker for breast cancer.
Customer Reviews (3)
Write a reviewNot only does it provide reliable and consistent results due to its high quality and purity, but it also holds significant value in understanding cellular processes and disease mechanisms.
the CTNNB1 protein offers numerous advantages in trials and research experiments.
This commitment to excellence ensures that researchers are provided with the most advanced and reliable tools for their investigations.
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