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CYP24A1

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Official Full Name
cytochrome P450, family 24, subfamily A, polypeptide 1
Background
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This mitochondrial protein initiates the degradation of 1,25-dihydroxyvitamin D3, the physiologically active form of vitamin D3, by hydroxylation of the side chain. In regulating the level of vitamin D3, this enzyme plays a role in calcium homeostasis and the vitamin D endocrine system. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Synonyms
CYP24A1; cytochrome P450, family 24, subfamily A, polypeptide 1; CYP24, cytochrome P450, subfamily XXIV (vitamin D 24 hydroxylase); 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial; CP24; P450 CC24; mitochondrial; 1 25 @dihydroxyvitamin D3 24 hydroxylase; 1 25 dihydroxyvitamin D(3) 24 hydroxylase; 1; 24 ohase; 24-OHase; 25-dihydroxyvitamin D(3) 24-hydroxylase; CP 24; CP24A_HUMAN; CYP 24; CYP24; Cytochrome P450 24A1; Cytochrome P450 24A1 mitochondrial; Cytochrome P450 family 24; Cytochrome P450 family 24 subfamily A polypeptide 1; Cytochrome P450 subfamily XXIV; Cytochrome P450, subfamily XXIV (vitamin D 24-hydroxylase); Cytochrome P450-CC24; EC 1.14.13.n4; Exo mitochondrial protein; MGC126273; MGC126274; Vitamin D 24 hydroxylase; Vitamin D(3) 24 hydroxylase; Vitamin D(3) 24-hydroxylase; OTTHUMP00000031314; OTTHUMP00000165939; OTTHUMP00000165940; vitamin D 24-hydroxylase; exo-mitochondrial protein; 1,25-@dihyd; HCAI; P450-CC24
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Involved Pathway
CYP24A1 involved in several pathways and played different roles in them. We selected most pathways CYP24A1 participated on our site, such as Biological oxidations, Cytochrome P450 - arranged by substrate type, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP24A1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Biological oxidations
DPEP1; CYP11B2; CYP17A1; GSTO2; FDXR; ACY3.2; CYP2V1; CYP2N13; CYP2D6; ABHD10
Cytochrome P450 - arranged by substrate type
CYP1A1; CYP17A1; CYP3A4; CYP2V1; CYP2E1; CYP2AD3; CYP2K19; CYP8B2; FDX1L; CYP2R1
Metabolic pathways
DGUOK; NMNAT2; NDUFB10; UGT2A2; NMRK1; POLR2G; PLD1A; GLS2; ATP6V1E1B; B3GNT4
Metabolism
PNP5B; HS3ST4; MMADHC; SULT4A1; GGTLC1; DDAH2; CRAT; KCNJ11; ARL2BP; D2HGDH
Metabolism of lipids and lipoproteins
DECR1; CYP27B1; DPEP2; YY2; GRHL1; APOA4B.2; APOA4B.1; GDF1; CYP4T8; PPM1L
Metabolism of steroid hormones and vitamin D
PPP1R2; GC; CYP27B1; HSD17B11; AKR1B15; CYP24A1; CYP2R1; STARD5
MicroRNAs in cancer
PDGFA; CCND1; SLC7A1; ZEB1; DNMT1; CCND2; RPTOR; NFKB1; IGF2BP1; ZEB2
Nuclear receptors in lipid metabolism and toxicity
CYP26A1; CYP24A1; ABCC2; RARGA; VDRB; RARGB; RARG; CYP27B1; NR1I2; NR1I3
Protein Function
CYP24A1 has several biochemical functions, for example, 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity, 25-hydroxycholecalciferol-24-hydroxylase activity, heme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP24A1 itself. We selected most functions CYP24A1 had, and list some proteins which have the same functions with CYP24A1. You can find most of the proteins on our site.
Function
Related Protein
Function1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity
Related ProteinCYP24A1
Function25-hydroxycholecalciferol-24-hydroxylase activity
Related ProteinCYP24A1
Functionheme binding
Related ProteinSDHC; CYP2X7; NOX5; CYP2AA4; SUOX; CYP46A1.4; CYP4F18; CYP2V1; CYP2AA6; CYP3A4
Functioniron ion binding
Related ProteinCYP46A1.4; OGFOD2; PPEF1; IRGM1; CYP1A; NOS2A; CYP2AA8; CYP2AD2; CYP2N13; HBBE3
Functionoxidoreductase activity
Related ProteinCYP2C19; VAT1; SERPINB1A; AKR7A5; ALDH9A1B; CYP2C37; DPYDB; CMAH; HADHAA; KDM1A
Interacting Protein
CYP24A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP24A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP24A1.
Dlg4; ECSIT

CYP24A1 Related Articles
>> Sidhu, PS; Teske, K; et al. Anticancer activity of VDR-coregulator inhibitor PS121912. CANCER CHEMOTHERAPY AND PHARMACOLOGY 74:787-798(2014).
>> Girgis, CM; Mokbel, N; et al. The Vitamin D Receptor (VDR) Is Expressed in Skeletal Muscle of Male Mice and Modulates 25-Hydroxyvitamin D (25OHD) Uptake in Myofibers. ENDOCRINOLOGY 155:3227-3237(2014).

45-1 Ramsey Road, Shirley, NY 11967, USA
USA: 1-631-559-9269  1-631-448-7888
Europe: 44-207-048-3343
FAX: 1-631-938-8127
EMAIL: info@creative-biomart.com

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