cyp24a1
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  • Official Full Name
  • cytochrome P450, family 24, subfamily A, polypeptide 1
  • Background
  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This mitochondrial protein initiates the degradation of 1,25-dihydroxyvitamin D3, the physiologically active form of vitamin D3, by hydroxylation of the side chain. In regulating the level of vitamin D3, this enzyme plays a role in calcium homeostasis and the vitamin D endocrine system. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • CYP24A1; cytochrome P450, family 24, subfamily A, polypeptide 1; CYP24, cytochrome P450, subfamily XXIV (vitamin D 24 hydroxylase); 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial; CP24; P450 CC24; mitochondrial; 1 25 @dihydroxyvitamin D3 24 hydroxylase; 1 25 dihydroxyvitamin D(3) 24 hydroxylase; 1; 24 ohase; 24-OHase; 25-dihydroxyvitamin D(3) 24-hydroxylase; CP 24; CP24A_HUMAN; CYP 24; CYP24; Cytochrome P450 24A1; Cytochrome P450 24A1 mitochondrial; Cytochrome P450 family 24; Cytochrome P450 family 24 subfamily A polypeptide 1; Cytochrome P450 subfamily XXIV; Cytochrome P450, subfamily XXIV (vitamin D 24-hydroxylase); Cytochrome P450-CC24; EC 1.14.13.n4; Exo mitochondrial protein; MGC126273; MGC126274; Vitamin D 24 hydroxylase; Vitamin D(3) 24 hydroxylase; Vitamin D(3) 24-hydroxylase; OTTHUMP00000031314; OTTHUMP00000165939; OTTHUMP00000165940; vitamin D 24-hydroxylase; exo-mitochondrial protein; 1,25-@dihyd; HCAI; P450-CC24
Cat.#:CYP24A1-11768HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CYP24A1, His-tagged
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Cat.#:CYP24A1-251HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human CYP24A1, GST-tagged
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Cat.#:Cyp24a1-8075MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Cyp24a1 protein, His & T7-tagged
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Cat.#:CYP24A1-1719RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CYP24A1 Protein
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Cat.#:CYP24A1-6538CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CYP24A1
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Cat.#:CYP24A1-5569ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CYP24A1
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Cat.#:CYP24A1-7122HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CYP24A1 293 Cell Lysate
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Involved Pathway

CYP24A1 involved in several pathways and played different roles in them. We selected most pathways CYP24A1 participated on our site, such as Biological oxidations, Cytochrome P450 - arranged by substrate type, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP24A1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Biological oxidations
CYP1B1; ACSM1; CYP1A2; SULT1ST6; CYP3A7-CYP3AP1; CYP46A1; CYP24A1; PAOX; SLC35D1A; GLYAT
Cytochrome P450 - arranged by substrate type
CYP2W1; CYP17A1; CYP2S1; CYP2A6; CYP2K18; CYP2K16; CYP3A5; CYP2AD3; FDX1L; CYP2D6
Metabolic pathways
GLCE; GAPDH; ASL2; NDUFA3; C1GALT1C1; INPP5B; GBE1; RPIA; CNDP1; MGAT3
Metabolism
MED20; B4GALT7; FTCD; CYP2A13; NUDT1; CYP2R1; SLC44A5B; DPEP1; OXSR1; SLC25A15A
Metabolism of lipids and lipoproteins
CERS4A; SLC25A20; MTF1; APOF; PPM1LB; THEM5; CYP2Y3; GLTP; GPAT2; SLC25A1A
Metabolism of steroid hormones and vitamin D
GC; AKR1B15; CYP24A1; HSD17B11; STARD5; CYP2R1; CYP27B1; PPP1R2
MicroRNAs in cancer
WNT3A; TRP53; KIF23; MMP16; CDCA5; ABCB1; DNMT1; VIM; PDCD4; DDIT4
Nuclear receptors in lipid metabolism and toxicity
CYP27B1; CYP24A1; RARGA; RARG; ABCC2; NR1I2; CYP26A1; NR1I3; RARGB; VDRB

Protein Function

CYP24A1 has several biochemical functions, for example, 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity, 25-hydroxycholecalciferol-24-hydroxylase activity, heme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP24A1 itself. We selected most functions CYP24A1 had, and list some proteins which have the same functions with CYP24A1. You can find most of the proteins on our site.
Function
Related Protein
Function 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity
Related Protein CYP24A1
Function 25-hydroxycholecalciferol-24-hydroxylase activity
Related Protein CYP24A1
Function heme binding
Related Protein PTGESL; CYP2K16; CYP2A4; HBD; CYP2AA7; CYP2AA12; CYP2C54; CYP2W1; CYP4A14; CYP46A1
Function iron ion binding
Related Protein CYP26B1; HBBE3; CYP11C1; NOS3; CYP2A7; CYP2Y3; CYP8B3; FDX1; TPH1A; HBBE2
Function oxidoreductase activity
Related Protein CYP2E1; SDR16C6; AKR1A1A; CH25HL2; HSD3B6; SPRB; ALOX5B.2; FADS1; IYD; DHRS4L2

Interacting Protein

CYP24A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP24A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP24A1.
Dlg4; ECSIT

CYP24A1 Related Articles

Sidhu, PS; Teske, K; et al. Anticancer activity of VDR-coregulator inhibitor PS121912. CANCER CHEMOTHERAPY AND PHARMACOLOGY 74:787-798(2014).
Girgis, CM; Mokbel, N; et al. The Vitamin D Receptor (VDR) Is Expressed in Skeletal Muscle of Male Mice and Modulates 25-Hydroxyvitamin D (25OHD) Uptake in Myofibers. ENDOCRINOLOGY 155:3227-3237(2014).