cyp2d6
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  • Official Full Name
  • Cytochrome P450, Family 2, Subfamily D, Polypeptide 6
  • Background
  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 20% of commonly prescribed drugs. Its substrates include debrisoquine, an adrenergic-blocking drug; sparteine and propafenone, both anti-arrythmic drugs; and amitryptiline, an anti-depressant. The gene is highly polymorphic in the population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. The gene is located near two cytochrome P450 pseudogenes on chromosome 22q13.1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • CPD6; CYP2D; CYP2DL1; CYPIID6; P450C2D; P450DB1; CYP2D7AP; CYP2D7BP; CYP2D7P2; CYP2D8P2; P450-DB1; MGC120389; MGC120390; CYP2D6; cytochrome P450, family 2, subfamily D, polypeptide 6; cytochrome P450 2D6; OTTHUMP00000198705; OTTHUMP00000198706; cytochrome P450-DB1; microsomal monooxygenase; xenobiotic monooxygenase; debrisoquine 4-hydroxylase; flavoprotein-linked monooxygenase; cytochrome P450, family 2, subfamily D, polypeptide 7 pseudogene 2; cytochrome P450, family 2, subfamily D, polypeptide 8 pseudogene 2; cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing)-like 1; cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing), polypeptide 6; cytochrome P450, subfamily II (debrisoquine, sparteine, etc., -metabolising), polypeptide 7 pseudogene 2; cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolising), polypeptide 8 pseudogene 2; Debrisoquine 4 hydroxylase; EC 1.14.14.1; Flavoprotein linked monooxygenase; P450 DB1
Cat.#:CYP2D6-11775HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CYP2D6, GST-tagged
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Cat.#:CYP2D6-225HTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human CYP2D6
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Cat.#:CYP2D6-250HTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human CYP2D6
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Cat.#:CYP2D6-26689THTag:
Source (Host):Species:Human
Product nameRecombinant Human CYP2D6
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Cat.#:CYP2D6-34HTag:
Source (Host):Pichia pastorisSpecies:Human
Product nameRecombinant Human CYP2D6/NADPH reductase protein
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Cat.#:CYP2D6-7965HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CYP2D6 protein, His-tagged
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Cat.#:CYP2D6-1153RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CYP2D6 Protein, His-tagged
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Cat.#:CYP2D6-4143CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CYP2D6
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Cat.#:CYP2D6-7112HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CYP2D6 293 Cell Lysate
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Cat.#:Kit-2134Tag:
Source (Host):Species:
Product nameCytochrome P450 2D6 Fluorometric Activity Assay Kit
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Cat.#:Kit-2135Tag:
Source (Host):Species:
Product nameCytochrome P450 2D6 Inhibitor Screening Kit
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Cat.#:Kit-0902Tag:
Source (Host):Species:
Product nameCYP2D6 Cyan Screening Kit
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Cat.#:Kit-0940Tag:
Source (Host):Species:
Product nameCYP2D6 Blue Screening Kit
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CYP2D6 Related Articles

Wang, DX; Papp, AC; et al. Functional characterization of CYP2D6 enhancer polymorphisms. HUMAN MOLECULAR GENETICS 24:1556-1562(2015).
Hintermann, E; Ehser, J; et al. Mechanism of autoimmune hepatic fibrogenesis induced by an adenovirus encoding the human liver autoantigen cytochrome P450 2D6. JOURNAL OF AUTOIMMUNITY 44:49-60(2013).