DCK
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Official Full Name
deoxycytidine kinase
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Overview
Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs.Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents.Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives.DCK is clinically important because of its relationship to drug resistance and sensitivity. -
Synonyms
DCK; deoxycytidine kinase; DCK protein; DCK_HUMAN; OTTHUMP00000160356; OTTHUMP00000219118; OTTHUMP00000219119; deoxynucleoside kinase;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Assay Kits
- Bacillus subtilis
- Chicken
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E. coli or Yeast
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Sf9 Insect Cell
- Wheat Germ
- DDK
- GST
- His
- His (Fc)
- Avi
- Strep
- Myc
- N/A
- N
- T7
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
- DCK Related Articles
DCK involved in several pathways and played different roles in them. We selected most pathways DCK participated on our site, such as Metabolic pathways, Metabolism, Metabolism of nucleotides, which may be useful for your reference. Also, other proteins which involved in the same pathway with DCK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Metabolic pathways | PFKMB;ATP6V0D1;NME1;ACADM;LDHBA;MOCS1;CKMT1;MTMR3;GAD1 |
Metabolism | SLC44A5B;PDK3;ELA2;DCK;ARSH;ADSSL1;SLC26A2;MED10;MED31 |
Metabolism of nucleotides | NUDT5;NUDT1;NUDT15;DHODH;UPP2;DCK;ADAL;DGUOK;AK7A |
Purine metabolism | PDE6C;PNP5A;NT5M;NUDT5;GUK1A;APRT;ENTPD2A.1;CANT1;UOX |
Purine salvage | DCK;TM9SF1;ADK;DGUOK;ADAL;PNP5B;ADA |
Pyrimidine metabolism | NME2A;NT5E;POLR2C;ENTPD6;TXNRD2;NME3;POLR3D;ENTPD4;POLR3GLB |
Pyrimidine salvage reactions | UPP2;DCK |
RB in Cancer | HLTF;TOP2A;RABIF;RBP1;DCK;ANLN;PRMT2;FAF1;HMGB2 |
DCK has several biochemical functions, for example, ATP binding, deoxycytidine kinase activity, drug binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DCK itself. We selected most functions DCK had, and list some proteins which have the same functions with DCK. You can find most of the proteins on our site.
Function | Related Protein |
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ATP binding | DGKB;STK35;CHST13;ABCG2C;FIGNL2;P2RX4B;ITPKB;TAP1;MAST2 |
deoxycytidine kinase activity | TK2;DCK |
drug binding | PPARG;FSCN1;GABRA1;PDXK;FOLR1;DRD4;CHRM3;DHODH;MT3 |
nucleoside kinase activity | UCK2B;DCK;UCK2A;TK1;UCK2;UCK1;DGUOK |
protein homodimerization activity | MCL1;XPNPEP1;TIGIT;UXS1;IZUMO1;UBE4A;ROPN1B;HOGA1;PRPS1 |
DCK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DCK here. Most of them are supplied by our site. Hope this information will be useful for your research of DCK.
MED19; TFEC; RXRG; GOLM1; DDX19B; bosutinib
- Q&As
- Reviews
Q&As (7)
Ask a questionReduced DCK activity or expression can lead to resistance against nucleoside analog-based chemotherapy.
Strategies include modulating DCK levels to overcome drug resistance and improve treatment outcomes.
DCK activation of prodrugs enhances their cytotoxicity, improving chemotherapeutic efficacy.
Genetic variants in DCK have been linked to varied responses to nucleoside analog drugs.
It phosphorylates deoxyribonucleosides, contributing to their conversion to active triphosphate forms.
DCK is widely expressed but shows higher activity in proliferating cells and certain tissues like the liver.
DCK plays a crucial role in activating nucleoside analog prodrugs.
Customer Reviews (3)
Write a reviewWorked as expected, pure.
Excellent for research, quality.
Fast shipping, reliable product.
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