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DCK

  • Official Full Name

    deoxycytidine kinase

  • Overview

    Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs.Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents.Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives.DCK is clinically important because of its relationship to drug resistance and sensitivity.
  • Synonyms

    DCK; deoxycytidine kinase; DCK protein; DCK_HUMAN; OTTHUMP00000160356; OTTHUMP00000219118; OTTHUMP00000219119; deoxynucleoside kinase;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Bacillus subtilis
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E. coli or Yeast
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Sf9 Insect Cell
  • Wheat Germ
  • DDK
  • GST
  • His
  • His (Fc)
  • Avi
  • Strep
  • Myc
  • N/A
  • N
  • T7
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DCK-185H Active Recombinant Human DCK protein E.coli N/A
Human DCK-857H Recombinant Human DCK Protein, DDK-tagged Sf9 Insect Cell DDK
Human DCK-11853H Recombinant Human DCK, GST-tagged E.coli GST 1-260a.a.
Human DCK-27365TH Recombinant Human DCK Protein, His-tagged E.coli His
Human DCK-796H Recombinant Human DCK, His-tagged Sf9 Insect Cell His
Human DCK-795H Recombinant Human Deoxycytidine Kinase, His-tagged E.coli His
Human DCK-2390H Recombinant Human DCK Protein, GST-tagged Wheat Germ GST
Human DCK-7051HCL Recombinant Human DCK 293 Cell Lysate HEK293 N/A
Human DCK-734H Recombinant Human DCK Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human DCK-0825H Recombinant Human DCK Protein (M1-L260), His/Strep tagged E.coli His/Strep M1-L260
Human DCK-1927H Recombinant Human DCK Protein (Met1-Leu260), N-His tagged E.coli N-His Met1-Leu260
Human DCK-1928H Recombinant Human DCK Protein (Met1-Leu260), N-His and T7 tagged E.coli N-His and T7 Met1-Leu260
Human DCK-2803HF Recombinant Full Length Human DCK Protein, GST-tagged In Vitro Cell Free System GST 260 amino acids
Human DCK-0824H Recombinant Human DCK Protein (M1-L260), Tag Free E.coli No tag M1-L260
Mouse DCK-4349M Recombinant Mouse DCK Protein Mammalian Cell His
Mouse Dck-2472M Recombinant Mouse Dck Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse DCK-2231M Recombinant Mouse DCK Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse DCK-2231M-B Recombinant Mouse DCK Protein Pre-coupled Magnetic Beads HEK293
Rat DCK-1793R Recombinant Rat DCK Protein Mammalian Cell His
Rat DCK-1451R Recombinant Rat DCK Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat DCK-1451R-B Recombinant Rat DCK Protein Pre-coupled Magnetic Beads HEK293
Bacillus subtilis DCK-2265B Recombinant Bacillus subtilis DCK protein, His-tagged E. coli or Yeast His
Rhesus Macaque DCK-1191R Recombinant Rhesus monkey DCK Protein, His-tagged Mammalian Cell His
Rhesus Macaque DCK-1016R Recombinant Rhesus Macaque DCK Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque DCK-1016R-B Recombinant Rhesus Macaque DCK Protein Pre-coupled Magnetic Beads HEK293
Zebrafish DCK-1626Z Recombinant Zebrafish DCK Mammalian Cell His
Chicken DCK-1591C Recombinant Chicken DCK Mammalian Cell His
Kit-0879 dCK Screening Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • DCK Related Articles

DCK involved in several pathways and played different roles in them. We selected most pathways DCK participated on our site, such as Metabolic pathways, Metabolism, Metabolism of nucleotides, which may be useful for your reference. Also, other proteins which involved in the same pathway with DCK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Metabolic pathwaysPFKMB;ATP6V0D1;NME1;ACADM;LDHBA;MOCS1;CKMT1;MTMR3;GAD1
MetabolismSLC44A5B;PDK3;ELA2;DCK;ARSH;ADSSL1;SLC26A2;MED10;MED31
Metabolism of nucleotidesNUDT5;NUDT1;NUDT15;DHODH;UPP2;DCK;ADAL;DGUOK;AK7A
Purine metabolismPDE6C;PNP5A;NT5M;NUDT5;GUK1A;APRT;ENTPD2A.1;CANT1;UOX
Purine salvageDCK;TM9SF1;ADK;DGUOK;ADAL;PNP5B;ADA
Pyrimidine metabolismNME2A;NT5E;POLR2C;ENTPD6;TXNRD2;NME3;POLR3D;ENTPD4;POLR3GLB
Pyrimidine salvage reactionsUPP2;DCK
RB in CancerHLTF;TOP2A;RABIF;RBP1;DCK;ANLN;PRMT2;FAF1;HMGB2

DCK has several biochemical functions, for example, ATP binding, deoxycytidine kinase activity, drug binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DCK itself. We selected most functions DCK had, and list some proteins which have the same functions with DCK. You can find most of the proteins on our site.

Function Related Protein
ATP bindingDGKB;STK35;CHST13;ABCG2C;FIGNL2;P2RX4B;ITPKB;TAP1;MAST2
deoxycytidine kinase activityTK2;DCK
drug bindingPPARG;FSCN1;GABRA1;PDXK;FOLR1;DRD4;CHRM3;DHODH;MT3
nucleoside kinase activityUCK2B;DCK;UCK2A;TK1;UCK2;UCK1;DGUOK
protein homodimerization activityMCL1;XPNPEP1;TIGIT;UXS1;IZUMO1;UBE4A;ROPN1B;HOGA1;PRPS1

DCK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DCK here. Most of them are supplied by our site. Hope this information will be useful for your research of DCK.

MED19; TFEC; RXRG; GOLM1; DDX19B; bosutinib

Zhuang, XM; Deng, JT; et al. Metabolism of novel anti-HIV agent 3-cyanomethyl-4-methyl-DCK by human liver microsomes and recombinant CYP enzymes. ACTA PHARMACOLOGICA SINICA 32:1276-1284(2011).
Fong, WF; Shen, XL; et al. Methoxylation of 3 ',4 '-aromatic side chains improves P-glycoprotein inhibitory and multidrug resistance reversal activities of 7,8-pyranocoumarin against cancer cells. BIOORGANIC & MEDICINAL CHEMISTRY 16:3694-3703(2008).
  • Q&As
  • Reviews

Q&As (7)

Ask a question
How is DCK implicated in resistance to chemotherapy? 09/01/2022

Reduced DCK activity or expression can lead to resistance against nucleoside analog-based chemotherapy.

What therapeutic strategies are being explored to modulate DCK activity? 07/10/2021

Strategies include modulating DCK levels to overcome drug resistance and improve treatment outcomes.

What is the significance of DCK in the action of certain chemotherapeutic agents? 04/28/2021

DCK activation of prodrugs enhances their cytotoxicity, improving chemotherapeutic efficacy.

Are there known genetic variants of DCK associated with different responses to treatment? 09/14/2020

Genetic variants in DCK have been linked to varied responses to nucleoside analog drugs.

How does DCK contribute to nucleoside metabolism? 08/27/2018

It phosphorylates deoxyribonucleosides, contributing to their conversion to active triphosphate forms.

In which types of cells or tissues is DCK predominantly expressed? 06/17/2018

DCK is widely expressed but shows higher activity in proliferating cells and certain tissues like the liver.

What is the primary role of DCK in cellular processes? 02/22/2018

DCK plays a crucial role in activating nucleoside analog prodrugs.

Customer Reviews (3)

Write a review
Reviews
08/05/2020

    Worked as expected, pure.

    07/01/2020

      Excellent for research, quality.

      07/26/2018

        Fast shipping, reliable product.

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