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Official Full Name
deoxycytidine kinase
Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs.Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents.Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives.DCK is clinically important because of its relationship to drug resistance and sensitivity.
DCK; deoxycytidine kinase; DCK protein; DCK_HUMAN; OTTHUMP00000160356; OTTHUMP00000219118; OTTHUMP00000219119; deoxynucleoside kinase
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DCK Related Articles
>> Zhuang, XM; Deng, JT; et al. Metabolism of novel anti-HIV agent 3-cyanomethyl-4-methyl-DCK by human liver microsomes and recombinant CYP enzymes. ACTA PHARMACOLOGICA SINICA 32:1276-1284(2011).
>> Fong, WF; Shen, XL; et al. Methoxylation of 3 ',4 '-aromatic side chains improves P-glycoprotein inhibitory and multidrug resistance reversal activities of 7,8-pyranocoumarin against cancer cells. BIOORGANIC & MEDICINAL CHEMISTRY 16:3694-3703(2008).

45-1 Ramsey Road, Shirley, NY 11967, USA
USA: 1-631-559-9269  1-631-448-7888
Europe: 44-207-048-3343
FAX: 1-631-938-8127

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