DDC
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Official Full Name
dopa decarboxylase (aromatic L-amino acid decarboxylase)
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Overview
The encoded protein catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine,;L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Defects in this gene are the cause of aromatic;L-amino-acid decarboxylase deficiency (AADCD). AADCD deficiency is an inborn error in neurotransmitter metabolism that;leads to combined serotonin and catecholamine deficiency. Multiple alternatively spliced transcript variants encoding;different isoforms have been identified for this gene. -
Synonyms
DDC; dopa decarboxylase (aromatic L-amino acid decarboxylase); aromatic-L-amino-acid decarboxylase; AADC;
- Recombinant Proteins
- Cell & Tissue Lysates
- Antibody
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- E.Coli or Yeast
- HEK293
- HEK293T
- In Vitro Cell Free System
- Insect Cell
- Insect Cells
- Mammalian Cell
- Mammalian cells
- Rabbit
- C
- His
- Flag
- GST
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- N
- No tag
- T7
- Involved Pathway
- Protein Function
- Interacting Protein
- DDC Related Articles
- DDC Related Research Area
DDC involved in several pathways and played different roles in them. We selected most pathways DDC participated on our site, such as Alcoholism, Amine-derived hormones, Biogenic Amine Synthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with DDC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
Alcoholism | HIST1H4L;H2AFX;HDAC9;HIST1H2BJ;HIST1H2BL;HIST1H2BO;HDAC2;HIST1H4J;HIST1H2AA |
Amine-derived hormones | DBH;CGA;DIO2;TPH2;DDC |
Biogenic Amine Synthesis | DDC;DBH;CHAT;COMT |
Catecholamine biosynthesis | MOXD2;DBH;DDC |
Cocaine addiction | GRM3;RGS9;GRIN3B;CREB5;GNAS;GRIN1;GRIN3A;BDNF;PRKACB |
Dopamine metabolism | NQO1;DDC;COMT |
Dopaminergic synapse | AKT1;GNB2;CALML5;GNAL;PPP2CA;MAPK9;PPP2R5E;GNAS;CREB3L1 |
DDC has several biochemical functions, for example, L-dopa decarboxylase activity, amino acid binding, aromatic-L-amino-acid decarboxylase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DDC itself. We selected most functions DDC had, and list some proteins which have the same functions with DDC. You can find most of the proteins on our site.
Function | Related Protein |
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L-dopa decarboxylase activity | |
amino acid binding | GOT2;TPH1A;OTC;GCHFR;TPH1;TDO2;TPH2;AGXT;TPH1B |
aromatic-L-amino-acid decarboxylase activity | |
enzyme binding | PLCB1;TSPAN17;CYP3A4;PRKCE;YWHAH;HSPA1B;NFKBIA;HIST1H2AE;C2orf56 |
protein binding | SNF8;FRA10AC1;PPP3R1;VEGFC;FBXW9;SUCLA2;FSHB;IPO4;NFKBIA |
protein domain specific binding | WNT3A;Akap2;HSPA5;BASP1;SKI;STAMBP;SHROOM2;WNT3;RAP2B |
pyridoxal phosphate binding | PDXK;GPT2L;AGXT2L1;DDC;PDXDC1;CCBL2;SDSL;SPTLC2A;ACCS |
DDC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DDC here. Most of them are supplied by our site. Hope this information will be useful for your research of DDC.
AR; Ar; ATF6; RELA
- Q&As
- Reviews
Q&As (6)
Ask a questionThe parameters of the DDC experiment include capillary type, electric field strength, injection time, and extraction voltage. These parameters need to be optimized for the purpose of the experiment and the nature of the sample to ensure optimal ion extraction and mass spectrometry results.
Assessing the reliability of DDC experimental results can be achieved by comparing the reproducibility and consistency of protein abundance in different samples. In addition, the accuracy of experimental results can also be assessed using multiple internal standard proteins.
Validation of DDC experimental results can be achieved by comparing the consistency and repeatability of the types and quantities of proteins identified in different samples. In addition, DDC results can also be validated using other protein analysis techniques, such as Western blot.
Improving the resolution of DDC experiments can be achieved by optimizing parameters such as electric field strength, injection time, and lead-out voltage. In addition, choosing the right capillary material and diameter can also affect the resolution.
DDC results can be quantified by comparing the number of ions or protein abundance in different samples. Commonly used quantitative methods include internal standard method, external standard method, and isotope labeling method.
DDC experimental data needs to be processed and analyzed by professional software. Commonly used data processing methods include background subtraction, noise filtering, ion peak identification, and mass spectral interpretation.
Customer Reviews (3)
Write a reviewAt the same dose, the protein has high expression characteristics.
The stability of this protein determines its easy storage properties.
DDC has high sensitivity and low detection limit.
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