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DDC

  • Official Full Name

    dopa decarboxylase (aromatic L-amino acid decarboxylase)

  • Overview

    The encoded protein catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine,;L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Defects in this gene are the cause of aromatic;L-amino-acid decarboxylase deficiency (AADCD). AADCD deficiency is an inborn error in neurotransmitter metabolism that;leads to combined serotonin and catecholamine deficiency. Multiple alternatively spliced transcript variants encoding;different isoforms have been identified for this gene.
  • Synonyms

    DDC; dopa decarboxylase (aromatic L-amino acid decarboxylase); aromatic-L-amino-acid decarboxylase; AADC;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Antibody
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • E.Coli or Yeast
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Mammalian cells
  • Rabbit
  • C
  • His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • N
  • No tag
  • T7
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DDC-141H Recombinant Human Dopa Decarboxylase, His-tagged E.coli His
Human DDC-28085TH Recombinant Human DDC E.coli N/A
Human DDC-284H Active Recombinant Human DDC protein(Met1-Glu480), His-tagged Insect Cells C-His Met1-Glu480
Human DDC-848H Recombinant Human DDC, T7-tagged E.coli T7
Human DDC-724HCL Recombinant Human DDC cell lysate Insect Cell N/A
Human DDC-915H Recombinant Human DDC Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human DDC-491H Recombinant Human DDC Protein, His-tagged E.coli His Leu200~Asn420
Human CAB11523RH Rabbit Anti-Human Dopa Decarboxylase Monoclonal Antibody Rabbit N/A
Human DDC-3118H Recombinant Human DDC Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human DDC-0240H Recombinant Human DDC Protein (M1-E480), Tag Free E.coli No tag M1-E480
Human DDC-2428HF Recombinant Full Length Human DDC Protein, GST-tagged In Vitro Cell Free System GST 480 amino acids
Human DDC-1314HFL Recombinant Full Length Human DDC Protein, C-Flag-tagged Mammalian cells Flag
Human DDC-731H Recombinant Human DDC Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human DDC-731H-B Recombinant Human DDC Protein Pre-coupled Magnetic Beads HEK293
Human DDC-1934H Recombinant Human DDC Protein (Leu200-Asn420), His tagged E.coli His Leu200-Asn420
Mouse DDC-915M Recombinant Mouse DDC Protein, His-tagged Insect Cell His
Mouse Ddc-2510M Recombinant Mouse Dopa Decarboxylase, His-tagged E.coli His 490 aa
Mouse DDC-513MCL Recombinant Mouse DDC cell lysate Insect Cell N/A
Mouse Ddc-2490M Recombinant Mouse Ddc Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Ddc-1322M Recombinant Mouse Ddc Protein, His-tagged E.coli N-His Lys58-Thr320
Rat Ddc-3638R Recombinant Rat Ddc, His-tagged E.Coli or Yeast His 480
Zebrafish DDC-12525Z Recombinant Zebrafish DDC Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • DDC Related Articles
  • DDC Related Research Area

DDC involved in several pathways and played different roles in them. We selected most pathways DDC participated on our site, such as Alcoholism, Amine-derived hormones, Biogenic Amine Synthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with DDC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
AlcoholismHIST1H4L;H2AFX;HDAC9;HIST1H2BJ;HIST1H2BL;HIST1H2BO;HDAC2;HIST1H4J;HIST1H2AA
Amine-derived hormonesDBH;CGA;DIO2;TPH2;DDC
Biogenic Amine SynthesisDDC;DBH;CHAT;COMT
Catecholamine biosynthesisMOXD2;DBH;DDC
Cocaine addictionGRM3;RGS9;GRIN3B;CREB5;GNAS;GRIN1;GRIN3A;BDNF;PRKACB
Dopamine metabolismNQO1;DDC;COMT
Dopaminergic synapseAKT1;GNB2;CALML5;GNAL;PPP2CA;MAPK9;PPP2R5E;GNAS;CREB3L1

DDC has several biochemical functions, for example, L-dopa decarboxylase activity, amino acid binding, aromatic-L-amino-acid decarboxylase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DDC itself. We selected most functions DDC had, and list some proteins which have the same functions with DDC. You can find most of the proteins on our site.

Function Related Protein
L-dopa decarboxylase activity
amino acid bindingGOT2;TPH1A;OTC;GCHFR;TPH1;TDO2;TPH2;AGXT;TPH1B
aromatic-L-amino-acid decarboxylase activity
enzyme bindingPLCB1;TSPAN17;CYP3A4;PRKCE;YWHAH;HSPA1B;NFKBIA;HIST1H2AE;C2orf56
protein bindingSNF8;FRA10AC1;PPP3R1;VEGFC;FBXW9;SUCLA2;FSHB;IPO4;NFKBIA
protein domain specific bindingWNT3A;Akap2;HSPA5;BASP1;SKI;STAMBP;SHROOM2;WNT3;RAP2B
pyridoxal phosphate bindingPDXK;GPT2L;AGXT2L1;DDC;PDXDC1;CCBL2;SDSL;SPTLC2A;ACCS

DDC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DDC here. Most of them are supplied by our site. Hope this information will be useful for your research of DDC.

AR; Ar; ATF6; RELA

Pi, LY; Robinson, PM; et al. Connective Tissue Growth Factor and Integrin alpha v beta 6: A New Pair of Regulators Critical for Ductular Reaction and Biliary Fibrosis in Mice. HEPATOLOGY 61:678-691(2015).
Yoshida, S; Ikenaga, N; et al. Extrahepatic Platelet-Derived Growth Factor-beta, Delivered by Platelets, Promotes Activation of Hepatic Stellate Cells and Biliary Fibrosis in Mice. GASTROENTEROLOGY 147:1378-1392(2014).
  • Q&As
  • Reviews

Q&As (6)

Ask a question
Why set the parameters of the DDC experiment? 07/17/2022

The parameters of the DDC experiment include capillary type, electric field strength, injection time, and extraction voltage. These parameters need to be optimized for the purpose of the experiment and the nature of the sample to ensure optimal ion extraction and mass spectrometry results.

How can I evaluate the reliability of the results of a DDC experiment? 07/16/2022

Assessing the reliability of DDC experimental results can be achieved by comparing the reproducibility and consistency of protein abundance in different samples. In addition, the accuracy of experimental results can also be assessed using multiple internal standard proteins.

How do I verify the results of a DDC experiment? 09/07/2021

Validation of DDC experimental results can be achieved by comparing the consistency and repeatability of the types and quantities of proteins identified in different samples. In addition, DDC results can also be validated using other protein analysis techniques, such as Western blot.

How can I improve the resolution of my DDC experiments? 03/06/2021

Improving the resolution of DDC experiments can be achieved by optimizing parameters such as electric field strength, injection time, and lead-out voltage. In addition, choosing the right capillary material and diameter can also affect the resolution.

Is it possible to quantify the results of DDC experiments? 01/13/2021

DDC results can be quantified by comparing the number of ions or protein abundance in different samples. Commonly used quantitative methods include internal standard method, external standard method, and isotope labeling method.

Can DDC experimental data be processed? 10/16/2020

DDC experimental data needs to be processed and analyzed by professional software. Commonly used data processing methods include background subtraction, noise filtering, ion peak identification, and mass spectral interpretation.

Customer Reviews (3)

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Reviews
12/23/2022

    At the same dose, the protein has high expression characteristics.

    11/16/2022

      The stability of this protein determines its easy storage properties.

      01/05/2022

        DDC has high sensitivity and low detection limit.

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