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DDC

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Official Full Name
dopa decarboxylase (aromatic L-amino acid decarboxylase)
Background
The encoded protein catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine,;L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Defects in this gene are the cause of aromatic;L-amino-acid decarboxylase deficiency (AADCD). AADCD deficiency is an inborn error in neurotransmitter metabolism that;leads to combined serotonin and catecholamine deficiency. Multiple alternatively spliced transcript variants encoding;different isoforms have been identified for this gene.
Synonyms
DDC; dopa decarboxylase (aromatic L-amino acid decarboxylase); aromatic-L-amino-acid decarboxylase; AADC
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DDC Related Articles
>> Pi, LY; Robinson, PM; et al. Connective Tissue Growth Factor and Integrin alpha v beta 6: A New Pair of Regulators Critical for Ductular Reaction and Biliary Fibrosis in Mice. HEPATOLOGY 61:678-691(2015).
>> Yoshida, S; Ikenaga, N; et al. Extrahepatic Platelet-Derived Growth Factor-beta, Delivered by Platelets, Promotes Activation of Hepatic Stellate Cells and Biliary Fibrosis in Mice. GASTROENTEROLOGY 147:1378-1392(2014).

45-1 Ramsey Road, Shirley, NY 11967, USA
USA: 1-631-559-9269  1-631-448-7888
Europe: 44-207-048-3343
FAX: 1-631-938-8127
EMAIL: info@creative-biomart.com

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