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DEFB1

  • Official Full Name

    defensin, beta 1

  • Overview

    Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 1, an antimicrobial peptide implicated in the resistance of epithelial surfaces to microbial colonization. This gene maps in close proximity to defensin family member, defensin, alpha 1 and has been implicated in the pathogenesis of cystic fibrosis.
  • Synonyms

    beta 1; BD 1; BD-1; BD1; Beta defensin 1; Beta-defensin 1; DEFB 1; DEFB1; DEFB1_HUMAN; DEFB101; Defensin; Defensin beta 1; Defensin beta 1 preproprotein; HBD 1; hBD-1; HBD1; MGC51822;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Cattle
  • Chicken
  • Human
  • Mouse
  • Pig
  • Rat
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • Human
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • Fc
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • His|S
  • SUMO
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DEFB1-035H Active Recombinant Human Defensin, Beta 1 Human N/A
Human DEFB1-17H Active Recombinant Human DEFB1 protein(1-47aa) E.coli N/A 1-47aa
Human DEFB1-197H Active Recombinant Human DEFB1 Protein E.coli N/A
Human DEFB1-11929H Recombinant Human DEFB1, GST-tagged E.coli GST 1-68a.a.
Human DEFB1-198H Recombinant Human DEFB1 protein E.coli N/A 47
Human DEFB1-2521H Recombinant Human DEFB1 Protein, GST-tagged Wheat Germ GST
Human DEFB1-455H Recombinant Human DEFB1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human DEFB1-6876H Recombinant Human DEFB1 protein, His & GST-tagged E.coli His/GST Gly22~Lys68 (Accession # P60022)
Human DEFB1-653H Recombinant Human DEFB1 Protein, Fc-tagged HEK293 Fc
Human DEFB1-27203TH Recombinant Human DEFB1 E.coli N/A
Human DEFB1-6989HCL Recombinant Human DEFB1 293 Cell Lysate HEK293 N/A
Human DEFB1-6715H Recombinant Human DEFB1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human DEFB1-2430HF Recombinant Full Length Human DEFB1 Protein, GST-tagged In Vitro Cell Free System GST 68 amino acids
Human DEFB1-134D Active Recombinant Human DEFB1 Protein (47 aa) E.coli 47
Human DEFB1-1946H Recombinant Human DEFB1 Protein (Gly22-Lys68), N-GST tagged E.coli N-GST Gly22-Lys68
Mouse Defb1-6877M Recombinant Mouse Defb1 protein, His & S-tagged E.coli His/S Val22~Ser69 (Accession # P56386)
Mouse Defb1-568M Recombinant Mouse Defb1 protein E.coli N/A 48
Mouse DEFB1-4464M Recombinant Mouse DEFB1 Protein Mammalian Cell His
Mouse DEFB1-2300M Recombinant Mouse DEFB1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse DEFB1-2300M-B Recombinant Mouse DEFB1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Defb1-2814M Recombinant Mouse Defb1 protein, His-SUMO-tagged E.coli His-SUMO 33-69aa
Rat Defb1-596R Recombinant Rat Defb1 protein E.coli N/A 37
Rat Defb1-6879R Recombinant Rat Defb1 protein, His-tagged E.coli His Ala22~Ser69 (Accession # O89117)
Rat DEFB1-1829R Recombinant Rat DEFB1 Protein Mammalian Cell His
Rat DEFB1-1487R-B Recombinant Rat DEFB1 Protein Pre-coupled Magnetic Beads HEK293
Rat DEFB1-1487R Recombinant Rat DEFB1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cattle DEFB1-6875C Recombinant Cattle DEFB1 protein, His & GST-tagged E.coli His/GST Arg2~Arg64
Rhesus Macaque DEFB1-1227R Recombinant Rhesus monkey DEFB1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque DEFB1-1052R Recombinant Rhesus Macaque DEFB1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque DEFB1-1052R-B Recombinant Rhesus Macaque DEFB1 Protein Pre-coupled Magnetic Beads HEK293
Pig DEFB1-6878P Recombinant Pig DEFB1 protein, His-tagged E.coli His Asn24~Lys64 (Accession # O62697)
Pig DEFB1-2705P Recombinant Pig DEFB1 Protein, His-tagged E.coli N-His Arg2-Arg69 (Accession # Q6R953)
Chicken DEFB1-6218C Recombinant Chicken DEFB1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

DEFB1 involved in several pathways and played different roles in them. We selected most pathways DEFB1 participated on our site, such as Beta defensins, Defensins, Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with DEFB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Beta defensinsDEFB104A;DEFB125;DEFB121;DEFB4B;DEFB103A;CCR6;DEFB116;DEFB129;DEFB4A
DefensinsDEFA6;DEFB4B;DEFB121;DEFB1;DEFB4A;DEFA5;CCR6;DEFB106A;DEFA1
Immune SystemRNF19B;GAN;BTR16;KIFAP3;IFIT10;CTSO;TRIM8;RNF34;MICA
Innate Immune SystemDEFB1;S100A12;MASP2;TNIP2;TXNIPA;LGALS3;POLR3H;PPAPDC1B;CD300LB

DEFB1 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by DEFB1 itself. We selected most functions DEFB1 had, and list some proteins which have the same functions with DEFB1. You can find most of the proteins on our site.

Function Related Protein

DEFB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DEFB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DEFB1.

RhoA; MAP4K2

  • Q&As
  • Reviews

Q&As (5)

Ask a question
Can DEFB1 be a potential therapeutic target for infectious diseases? 08/30/2022

Yes, the antimicrobial properties of DEFB1 make it a potential target for the development of novel therapeutics against various infectious diseases.

Can DEFB1 be used in combination with conventional antibiotics? 06/23/2022

Research suggests that combining DEFB1 with conventional antibiotics may enhance the overall antimicrobial activity and reduce the risk of antibiotic resistance.

How does DEFB1 interact with the microbiome? 07/08/2018

DEFB1 plays a role in maintaining the balance of the microbiome by preventing the overgrowth of harmful microorganisms. It contributes to the dynamic equilibrium in the microbial community.

Is DEFB1 involved in cancer development or suppression? 02/08/2017

Some studies suggest that DEFB1 may have a role in cancer, with evidence indicating both tumor-promoting and tumor-suppressing effects depending on the specific context.

Is there a genetic component to DEFB1 expression? 07/06/2016

Yes, variations in the DEFB1 gene can influence its expression levels, impacting an individual's susceptibility to certain infections and inflammatory conditions.

Customer Reviews (3)

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Reviews
03/12/2023

    the stability of the DEFB1 protein enables me to conduct experiments over an extended period, reducing the need for frequent restocking and promoting experimental consistency.

    02/06/2019

      The DEFB1 protein offers significant advantages in trials due to its high quality, purity, and stability.

      01/22/2018

        the manufacturer's exceptional support greatly enhances my research process.

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