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DES

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Official Full Name
desmin
Background
This gene encodes a muscle-specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. Mutations in this gene are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies. [provided by RefSeq, Jul 2008]
Synonyms
DES; desmin; CSM1; CSM2; LGMD2R; mutant desmin p.K241E; intermediate filament protein;
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Involved Pathway
DES involved in several pathways and played different roles in them. We selected most pathways DES participated on our site, such as Arrhythmogenic right ventricular cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Aurora B signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with DES were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Arrhythmogenic right ventricular cardiomyopathy
CTNNA2; DSP; CDH2; DSG2; JUP; CACNG2; DAG1; CTNNA1; CACNG3; DES
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
ITGAV; ITGA2; CACNG1; CACNG2; CDH2; DSP; ITGB4; ACTG1; ITGA9; LAMA2
Aurora B signaling
KIF2C; KIF20A; NCAPH; INCENP; PEBP1; AURKC; CENPA; RACGAP1; AURKB; NCAPD2
Dilated cardiomyopathy
ITGA10; ITGA1; MYBPC3; CACNG1; TPM2; CACNB3; IGF1; CACNG3; ITGA2B; PLN
Hypertrophic cardiomyopathy (HCM)
ITGB6; ITGA2; RYR2; ITGB7; SGCB; CACNA2D2; CACNA2D1; TGFB3; LMNA; TNNI3
Muscle contraction
TNNI1; SMYHC3; TNNI2; TRIM72; SORBS3; DES; ANXA2; MYBPC2B; DMD; DESMA
Striated Muscle Contraction
TCAP; TMOD2; TNNI2A.3; TNNI2; TNNI2A.1; VIML; DMD; TNNI2B.1; TMOD3; TNNT3
Protein Function
DES has several biochemical functions, for example, cytoskeletal protein binding, identical protein binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DES itself. We selected most functions DES had, and list some proteins which have the same functions with DES. You can find most of the proteins on our site.
Function
Related Protein
Functioncytoskeletal protein binding
Related ProteinALDOB; EZRA; PTPN4; FARP1; PACSIN1; TOR1AIP1; EZRB; ABI1; MSNA; NEBL
Functionidentical protein binding
Related ProteinUSP2; ALDOA; CCL3; CEP57L1; CLDN8; BNIP2; CLDN7; SOX10; ACPP; EGFR
Functionprotein binding
Related ProteinFCN1; SNRNP25; IRAK1BP1; MAP2K2; CPSF3; N6AMT1; NITR9; ZFAND2B; EXD1; TBC1D7
Functionstructural constituent of cytoskeleton
Related ProteinBICD1; NDC80; ACTL7A; TUBGCP2; ACTB; ACTL6B; SPTA1; ATXN1; CTNNA2; NEFL
Interacting Protein
DES has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DES here. Most of them are supplied by our site. Hope this information will be useful for your research of DES.
MTM1; MLH1

DES Related Articles
>> Liu, YC; Wang, Q; et al. Simultaneous Determination of Malachite Green, Diethylstilbestrol, Medroxyprogesterone, and 3-Amino-2-Oxazolidone in Synbranchoid Eels by a Protein Microarray Method. FOOD ANALYTICAL METHODS 8:1058-1066(2015).
>> Gonzales, I; Miranda, JJ; et al. Seizures, cysticercosis and rural-to-urban migration: the PERU MIGRANT study. TROPICAL MEDICINE & INTERNATIONAL HEALTH 20:546-552(2015).

45-1 Ramsey Road, Shirley, NY 11967, USA
USA: 1-631-559-9269  1-631-448-7888
Europe: 44-207-048-3343
FAX: 1-631-938-8127
EMAIL: info@creative-biomart.com

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