des
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  • Official Full Name
  • desmin
  • Background
  • This gene encodes a muscle-specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. Mutations in this gene are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies. [provided by RefSeq, Jul 2008]
  • Synonyms
  • DES; desmin; CSM1; CSM2; LGMD2R; mutant desmin p.K241E; intermediate filament protein;
Cat.#:DES-11943HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DES, GST-tagged
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Cat.#:DES-168HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant human DES
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Cat.#:DES-196HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human DES
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Cat.#:DES-289HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DES protein, His/MBP-tagged
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Cat.#:DES-328HTag:DDK
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human DES Protein, DDK-tagged
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Cat.#:DES-329HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DES Protein, His-tagged
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Cat.#:DES-330HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DES Protein, His-tagged
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Cat.#:DES-534HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DES Protein, His-tagged
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Cat.#:DES-4526MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse DES Protein
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Cat.#:DES-1847RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat DES Protein
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Cat.#:DES-1246RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey DES Protein, His-tagged
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Cat.#:DES-0978BTag:His
Source (Host):E. coli or YeastSpecies:Bacillus subtilis
Product nameRecombinant Bacillus subtilis DES protein, His-tagged
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Cat.#:DES-113HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Desmin
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Cat.#:DES-167CTag:
Source (Host):Species:Chicken
Product nameNative chicken DES
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Cat.#:DES-6969HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human DES 293 Cell Lysate
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Involved Pathway

DES involved in several pathways and played different roles in them. We selected most pathways DES participated on our site, such as Arrhythmogenic right ventricular cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Aurora B signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with DES were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Arrhythmogenic right ventricular cardiomyopathy
CTNNA1; DMD; CDH2; CACNG3; DSG2; DAG1; DES; CTNNA2; CACNG2; DSC2
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
LMNA; CACNG8; EMD; DMD; DAG1; ACTN3; CTNNA2; AASS; CTNNA1; SLC8A1
Aurora B signaling
CDCA8; AURKC; NPM1; DES; CBX5; NCAPD2; NDC80; RACGAP1; SGOL1; AURKB
Dilated cardiomyopathy
ITGA5; CACNG3; PRKACG; CACNA2D3; CACNA2D4; TPM2; Adcy4; IGF1; ITGA4; ACTC1
Hypertrophic cardiomyopathy (HCM)
TPM3; ITGA5; ATP2A2; ITGA10; ACTG1; ITGA8; PRKAB1; ITGB4; ITGA1; CACNA2D3
Muscle contraction
TNNT3A; DESMA; ANXA6; TCAP; MYBPC3; DESMB; SORBS3; MYL12A; LMOD1; TNNI2A.4
Striated Muscle Contraction
TMOD1; TMOD4; MYBPC1; TNNI1; TMEM8C; CMLC1; MYOM1; MYBPC2; MYLZ3; MYBPC2A

Protein Function

DES has several biochemical functions, for example, cytoskeletal protein binding, identical protein binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DES itself. We selected most functions DES had, and list some proteins which have the same functions with DES. You can find most of the proteins on our site.
Function
Related Protein
Function cytoskeletal protein binding
Related Protein DES; LIN7C; DYNLL2; ANXA2; EZRA; EPB41L5; PTPN4B; ALDOA; EPB4.1L4A; NEBL
Function identical protein binding
Related Protein SDCBP; CD247; HCFC1; PPP5C; CBS; ACTG1; TFRC; BRAP; DAPK3; ATF3
Function protein binding
Related Protein SEPT9; BICD1; PPM1K; PRNP; KIF9; NOTCH1; PDGFB; ZMYM5; DYRK1A; TMPRSS2
Function structural constituent of cytoskeleton
Related Protein BFSP2; VIM; ACTL7A; TUBA7L; ARPC5; EPB42; SPTAN1; KRT20; TUBA8; TUBB2

Interacting Protein

DES has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DES here. Most of them are supplied by our site. Hope this information will be useful for your research of DES.
MTM1; MLH1

DES Related Articles

Liu, YC; Wang, Q; et al. Simultaneous Determination of Malachite Green, Diethylstilbestrol, Medroxyprogesterone, and 3-Amino-2-Oxazolidone in Synbranchoid Eels by a Protein Microarray Method. FOOD ANALYTICAL METHODS 8:1058-1066(2015).
Gonzales, I; Miranda, JJ; et al. Seizures, cysticercosis and rural-to-urban migration: the PERU MIGRANT study. TROPICAL MEDICINE & INTERNATIONAL HEALTH 20:546-552(2015).