DVL2

  • Official Full Name

    dishevelled, dsh homolog 2

  • Overview

    Dishevelled (Dsh) proteins are important intermediates of Wnt signaling pathways. Dsh inhibits glycogen synthase kinase-3beta promoting beta-catenin stabilization. Dsh proteins also participate in the planar cell polarity pathway by acting through JNK. Th

  • Synonyms

    DVL2;dishevelled, dsh homolog 2 (Drosophila);dishevelled 2 (homologous to Drosophila dsh);segment polarity protein dishevelled homolog DVL-2;DSH homolog 2;dishevelled-2

Recombinant Proteins

  • Human
  • Zebrafish
  • Rhesus macaque
  • Mouse
  • E.coli
  • Mammalian Cells
  • HEK293
  • In Vitro Cell Free System
  • GST
  • His
  • Non
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
DVL2-108H Recombinant Human DVL2, GST-tagged E.coli Human GST False
DVL2-11925Z Recombinant Zebrafish DVL2 Mammalian Cells Zebrafish His
DVL2-1358R Recombinant Rhesus monkey DVL2 Protein, His-tagged Mammalian Cells Rhesus macaque His
DVL2-4900M Recombinant Mouse DVL2 Protein Mammalian Cells Mouse His
DVL2-6765HCL Recombinant Human DVL2 293 Cell Lysate HEK293 Human Non
DVL2-1183R Recombinant Rhesus Macaque DVL2 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
DVL2-1183R-B Recombinant Rhesus Macaque DVL2 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
DVL2-1844H Recombinant Human DVL2 protein, His-tagged E.coli Human His Leu78~Thr250
DVL2-2575M Recombinant Mouse DVL2 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
DVL2-2575M-B Recombinant Mouse DVL2 Protein Pre-coupled Magnetic Beads HEK293 Mouse
DVL2-6911HF Recombinant Full Length Human DVL2 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 736 amino acids

    Involved Pathway

    DVL2 involved in several pathways and played different roles in them. We selected most pathways DVL2 participated on our site, such as Asymmetric localization of PCP proteins,Basal cell carcinoma,Beta-catenin independent WNT signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with DVL2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    DNA damage response (only ATM dependent) MLKL,DVL3,DVL1,BIK
    Basal cell carcinoma FZD1,BMP4,SETD6,WNT5A,WNT9A,SUFU,Fzd4,FZD5,FZD3,BMP2
    Canonical Wnt signaling pathway DVL1,DVL3,CSNK1E,CSNK1A1,CSNK1D,KLHL12
    Asymmetric localization of PCP proteins PRICKLE1,PRICKLE1B
    HTLV-I infection NFKB1,NFATC2,CDC16,PDGFRB,HLA-F,WNT7B,HLA-C,SLC25A5,Il2,CDC23
    Beta-catenin independent WNT signaling DVL1,MOV10,PRICKLE1B,CLTA,AGO3,AP2A2,AP2S1,GNB5,CLTB,ROR1
    Disassembly of the destruction complex and recruitment of AXIN to the membrane WNT8-2,CSNK1G2,DVL1,DVL3
    Degradation of DVL HECW1,DACT1,DVL1,DVL3,HECW1B,KLHL12

    Protein Function

    DVL2 has several biochemical functions, for example, frizzled binding,identical protein binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DVL2 itself. We selected most functions DVL2 had, and list some proteins which have the same functions with DVL2. You can find most of the proteins on our site.

    Function Related Protein
    protein self-association ZKSCAN17,RYR2,ACVR2A,CTSB,SLC2A1,AGXT,TMEM43,ZNF496,TNFAIP3,BCL10
    protein binding CIZ1,TNFAIP8,SUCLA2,TMEM120B,SLC9A3,CD3E,Serpina1b,ACVR1L,PYGM,FKBP6
    identical protein binding S100A4,HOOK3,SLK,IMPA1,LRRK1,SFRP1,MID1,SMAD1,STAT6,KCTD13
    frizzled binding WNT9A,WNT5B,WNT4,WNT4B,WNT7B,WNT2,SDCBP,WNT3A,RNF43,WNT1
    protein domain specific binding XPA,RAB27B,HOMER2,DDX20,CHMP1A,CAPG,RHOA,STX1B,DBNL,HAND2

    Interacting Protein

    DVL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DVL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of DVL2.

    DACT1;Smurf2;Pard6a

    DVL2 Related Signal Pathway

    Resources

    Research Area

    References

    • Rao, C; Lin, SL; et al. High Expression of IGFBP7 in Fibroblasts Induced by Colorectal Cancer Cells Is Co-Regulated by TGF-beta and Wnt Signaling in a Smad2/3-Dvl2/3-Dependent Manner. PLOS ONE 9:-(2014).
    • Ye, ZD; Zhang, CX; et al. Wnt5a uses CD146 as a receptor to regulate cell motility and convergent extension. NATURE COMMUNICATIONS 4:-(2013).

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