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DVL2

  • Official Full Name

    dishevelled, dsh homolog 2

  • Overview

    Dishevelled (Dsh) proteins are important intermediates of Wnt signaling pathways. Dsh inhibits glycogen synthase kinase-3beta promoting beta-catenin stabilization. Dsh proteins also participate in the planar cell polarity pathway by acting through JNK. Th
  • Synonyms

    DVL2; dishevelled, dsh homolog 2 (Drosophila); dishevelled 2 (homologous to Drosophila dsh); segment polarity protein dishevelled homolog DVL-2; DSH homolog 2; dishevelled-2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DVL2-107H Recombinant Human DVL2, GST-tagged Wheat Germ GST
Human DVL2-108H Recombinant Human DVL2, GST-tagged E.coli GST False
Human DVL2-6765HCL Recombinant Human DVL2 293 Cell Lysate HEK293 N/A
Human DVL2-2012H Recombinant Human DVL2 Protein (Leu78-Thr250), His tagged E.coli His Leu78-Thr250
Human DVL2-1844H Recombinant Human DVL2 protein, His-tagged E.coli His Leu78~Thr250
Human DVL2-6911HF Recombinant Full Length Human DVL2 Protein, GST-tagged In Vitro Cell Free System GST 736 amino acids
Mouse DVL2-4900M Recombinant Mouse DVL2 Protein Mammalian Cell His
Mouse DVL2-2575M Recombinant Mouse DVL2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse DVL2-2575M-B Recombinant Mouse DVL2 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque DVL2-1358R Recombinant Rhesus monkey DVL2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque DVL2-1183R-B Recombinant Rhesus Macaque DVL2 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque DVL2-1183R Recombinant Rhesus Macaque DVL2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish DVL2-11925Z Recombinant Zebrafish DVL2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • DVL2 Related Articles
  • DVL2 Related Research Area
  • DVL2 Related Signal Pathway

DVL2 involved in several pathways and played different roles in them. We selected most pathways DVL2 participated on our site, such as Asymmetric localization of PCP proteins, Basal cell carcinoma, Beta-catenin independent WNT signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with DVL2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Asymmetric localization of PCP proteinsPRICKLE1;PRICKLE1B;DVL2
Basal cell carcinomaWNT10B;DVL3;WNT6;AXIN1;FZD8;WNT5B;BMP2;WNT8B;FZD2
Beta-catenin independent WNT signalingDVL3;ITPR2;ROR2;PRICKLE1;AP2M1;DVL2;AGO1;DVL1;CLTA
Canonical Wnt signaling pathwayCSNK1E;KLHL12;CSNK1D;DVL3;CSNK1A1;DVL1;DVL2
DNA damage response (only ATM dependent)MLKL;DVL1;DVL2;DVL3;BIK
Degradation of DVLDVL1;DACT1;DVL3;KLHL12;DVL2;HECW1B;HECW1
Disassembly of the destruction complex and recruitment of AXIN to the membraneCSNK1G2;DVL3;DVL2;DVL1;WNT8-2
HTLV-I infectionTGFB1;GSK3B;SLC2A1;ITGB2L;CALR;Fzd4;VDAC1;CDC23;WNT2

DVL2 has several biochemical functions, for example, frizzled binding, identical protein binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DVL2 itself. We selected most functions DVL2 had, and list some proteins which have the same functions with DVL2. You can find most of the proteins on our site.

Function Related Protein
frizzled bindingDVL1B;WNT2BA;NDP;WNT3A;CTHRC1;ZNRF3;ROR2;WNT5A;WNT9B
identical protein bindingMICALL1;CHMP4A;DAAM1;FZD1;BCHE;DAPK3;KCTD17;ASMT;KRTAP10-5
protein bindingDDC;BIK;FGF1;USH1C;XRCC1;DARS2;HBQ1;PEF1;CBS
protein domain specific bindingTH;WNT1;HSPA5;ATN1;YWHAH;CALM3;DBNL;MED12;DDX20
protein self-associationMDH2;RYR2;DYRK1A;MALT1;PROSAPIP1;RSAD2;AGTR1A;LDB1;AXIN1

DVL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DVL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of DVL2.

DACT1; Smurf2; Pard6a

Rao, C; Lin, SL; et al. High Expression of IGFBP7 in Fibroblasts Induced by Colorectal Cancer Cells Is Co-Regulated by TGF-beta and Wnt Signaling in a Smad2/3-Dvl2/3-Dependent Manner. PLOS ONE 9:-(2014).
Ye, ZD; Zhang, CX; et al. Wnt5a uses CD146 as a receptor to regulate cell motility and convergent extension. NATURE COMMUNICATIONS 4:-(2013).
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