INSIG1
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Official Full Name
insulin induced gene 1
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Overview
Oxysterols regulate cholesterol homeostasis through the liver X receptor (LXR)- and sterol regulatory element-binding protein (SREBP)-mediated signaling pathways. This gene is an insulin-induced gene. It encodes an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. This protein binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins. Alternatively spliced transcript variants encoding distinct isoforms have been observed. -
Synonyms
INSIG1; insulin induced gene 1; insulin-induced gene 1 protein; CL 6; INSIG 1 membrane protein; MGC1405; CL6; INSI1_HUMAN; INSIG 1; INSIG-1; INSIG1 membrane protein; Insulin induced gene 1 protein; INSIG-1 membrane protein; CL-6;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Bos taurus (Bovine)
- Chicken
- Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
- Cynomolgus Monkey
- Danio rerio (Zebrafish) (Brachydanio rerio)
- Gallus gallus (Chicken)
- Homo sapiens (Human)
- Human
- Mouse
- Mus musculus (Mouse)
- Rat
- Xenopus laevis (African clawed frog)
- Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
- Zebrafish
- E.coli
- E.coli expression system
- HEK293
- Mammalian Cell
- His
- His (Fc)
- Avi
- GST
- N/A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Human | INSIG1-124H | Recombinant Human INSIG1, His-tagged | E.coli | His | 1-90aa | |
Human | INSIG1-5193HCL | Recombinant Human INSIG1 293 Cell Lysate | HEK293 | N/A | ||
Human | INSIG1-5194HCL | Recombinant Human INSIG1 293 Cell Lysate | HEK293 | N/A | ||
Human | INSIG1-129H | Recombinant Human INSIG1 protein, His-GST-tagged | E.coli | His/GST | Met1~Arg87 | |
Mouse | INSIG1-8236M | Recombinant Mouse INSIG1 Protein | Mammalian Cell | His | ||
Mouse | INSIG1-4562M-B | Recombinant Mouse INSIG1 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Mouse | INSIG1-4562M | Recombinant Mouse INSIG1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rat | INSIG1-3078R | Recombinant Rat INSIG1 Protein | Mammalian Cell | His | ||
Rat | INSIG1-2734R | Recombinant Rat INSIG1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rat | INSIG1-2734R-B | Recombinant Rat INSIG1 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Bos taurus (Bovine) | RFL14093BF | Recombinant Full Length Bovine Insulin-Induced Gene 1 Protein(Insig1) Protein, His-Tagged | E.coli expression system | His | Full Length (1-276) | |
Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) | RFL3344CF | Recombinant Full Length Cricetulus Griseus Insulin-Induced Gene 1 Protein(Insig1) Protein, His-Tagged | E.coli expression system | His | Full Length (1-257) | |
Cynomolgus Monkey | INSIG1-624C | Recombinant Cynomolgus INSIG1 Protein, His-tagged | Mammalian Cell | His | ||
Cynomolgus Monkey | INSIG1-370C | Recombinant Cynomolgus Monkey INSIG1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Cynomolgus Monkey | INSIG1-370C-B | Recombinant Cynomolgus Monkey INSIG1 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Danio rerio (Zebrafish) (Brachydanio rerio) | RFL19353DF | Recombinant Full Length Danio Rerio Insulin-Induced Gene 1 Protein(Insig1) Protein, His-Tagged | E.coli expression system | His | Full Length (1-251) | |
Gallus gallus (Chicken) | RFL18028GF | Recombinant Full Length Chicken Insulin-Induced Gene 1 Protein(Insig1) Protein, His-Tagged | E.coli expression system | His | Full Length (1-252) | |
Homo sapiens (Human) | RFL34042HF | Recombinant Full Length Human Insulin-Induced Gene 1 Protein(Insig1) Protein, His-Tagged | E.coli expression system | His | Full Length (1-277) | |
Mus musculus (Mouse) | RFL12905MF | Recombinant Full Length Mouse Insulin-Induced Gene 1 Protein(Insig1) Protein, His-Tagged | E.coli expression system | His | Full Length (1-259) | |
Xenopus laevis (African clawed frog) | RFL8821XF | Recombinant Full Length Xenopus Laevis Insulin-Induced Gene 1 Protein(Insig1) Protein, His-Tagged | E.coli expression system | His | Full Length (1-251) | |
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | RFL27359XF | Recombinant Full Length Xenopus Tropicalis Insulin-Induced Gene 1 Protein(Insig1) Protein, His-Tagged | E.coli expression system | His | Full Length (1-251) | |
Zebrafish | INSIG1-10242Z | Recombinant Zebrafish INSIG1 | Mammalian Cell | His | ||
Chicken | INSIG1-2654C | Recombinant Chicken INSIG1 | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
- INSIG1 Related Articles
INSIG1 involved in several pathways and played different roles in them. We selected most pathways INSIG1 participated on our site, such as Metabolism, Metabolism of lipids and lipoproteins, Regulation of cholesterol biosynthesis by SREBP (SREBF), which may be useful for your reference. Also, other proteins which involved in the same pathway with INSIG1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Metabolism | COX16;KCNB1;CYP17A1;ACAD11;DCT;DHODH;ARSE;MAPK1IP1L;BPNT1 |
Metabolism of lipids and lipoproteins | TIAM2;CYP8B2;ANKRD1;MED21;ACOT7;ARSI;APOC2;SLC27A5;ACOT2 |
Regulation of cholesterol biosynthesis by SREBP (SREBF) | INSIG2;PMVK;YY2;NFYBB;INSIG1;DHCR7;MTF1;SREBF2;NFYBA |
SREBP signalling | RNF139;INSIG2;INSIG1;RBP4;DBI;SEC23B |
INSIG1 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by INSIG1 itself. We selected most functions INSIG1 had, and list some proteins which have the same functions with INSIG1. You can find most of the proteins on our site.
Function | Related Protein |
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protein binding | ATF4;KLF5;ANGPTL4;UNG;BAHD1;CRCP;ANGPT1;TMEM173;PML |
INSIG1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with INSIG1 here. Most of them are supplied by our site. Hope this information will be useful for your research of INSIG1.
SEC27; copa_schpo; CYP2C1; CYP2C2; COP1
- Q&As
- Reviews
Q&As (7)
Ask a questionINSIG1 contributes to cellular lipid droplet formation by influencing lipid homeostasis and storage in response to sterol levels.
While INSIG1 primarily regulates cholesterol synthesis, its indirect influence on triglyceride metabolism is observed through modulation of SREBP-regulated pathways.
INSIG1 promotes the degradation of HMG-CoA reductase, a key enzyme in cholesterol synthesis, through ubiquitination and proteasomal degradation.
There are no widely recognized small-molecule inhibitors or activators of INSIG1 identified to date.
INSIG1 is crucial in the feedback regulation of cholesterol synthesis, preventing excess cholesterol production by inhibiting the activation of SREBP proteins.
Yes, the expression of INSIG1 is responsive to changes in cellular sterol levels, serving as a key component of the sterol-sensing mechanism.
INSIG1 is involved in the unfolded protein response (UPR), a cellular stress response pathway associated with endoplasmic reticulum (ER) stress.
Customer Reviews (3)
Write a reviewWe found the product's safety and biocompatibility reassuring, especially when handling sensitive samples.
Precise immunoprecipitation results consistently reflected the product's quality.
The product's innovative characteristics enabled us to delve into previously uncharted cellular mechanisms.
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