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INSIG1

  • Official Full Name

    insulin induced gene 1

  • Overview

    Oxysterols regulate cholesterol homeostasis through the liver X receptor (LXR)- and sterol regulatory element-binding protein (SREBP)-mediated signaling pathways. This gene is an insulin-induced gene. It encodes an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. This protein binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
  • Synonyms

    INSIG1; insulin induced gene 1; insulin-induced gene 1 protein; CL 6; INSIG 1 membrane protein; MGC1405; CL6; INSI1_HUMAN; INSIG 1; INSIG-1; INSIG1 membrane protein; Insulin induced gene 1 protein; INSIG-1 membrane protein; CL-6;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bos taurus (Bovine)
  • Chicken
  • Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
  • Cynomolgus Monkey
  • Danio rerio (Zebrafish) (Brachydanio rerio)
  • Gallus gallus (Chicken)
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Xenopus laevis (African clawed frog)
  • Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • GST
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human INSIG1-124H Recombinant Human INSIG1, His-tagged E.coli His 1-90aa
Human INSIG1-5193HCL Recombinant Human INSIG1 293 Cell Lysate HEK293 N/A
Human INSIG1-5194HCL Recombinant Human INSIG1 293 Cell Lysate HEK293 N/A
Human INSIG1-129H Recombinant Human INSIG1 protein, His-GST-tagged E.coli His/GST Met1~Arg87
Mouse INSIG1-8236M Recombinant Mouse INSIG1 Protein Mammalian Cell His
Mouse INSIG1-4562M-B Recombinant Mouse INSIG1 Protein Pre-coupled Magnetic Beads HEK293
Mouse INSIG1-4562M Recombinant Mouse INSIG1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat INSIG1-3078R Recombinant Rat INSIG1 Protein Mammalian Cell His
Rat INSIG1-2734R Recombinant Rat INSIG1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat INSIG1-2734R-B Recombinant Rat INSIG1 Protein Pre-coupled Magnetic Beads HEK293
Bos taurus (Bovine) RFL14093BF Recombinant Full Length Bovine Insulin-Induced Gene 1 Protein(Insig1) Protein, His-Tagged E.coli expression system His Full Length (1-276)
Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) RFL3344CF Recombinant Full Length Cricetulus Griseus Insulin-Induced Gene 1 Protein(Insig1) Protein, His-Tagged E.coli expression system His Full Length (1-257)
Cynomolgus Monkey INSIG1-624C Recombinant Cynomolgus INSIG1 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey INSIG1-370C Recombinant Cynomolgus Monkey INSIG1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey INSIG1-370C-B Recombinant Cynomolgus Monkey INSIG1 Protein Pre-coupled Magnetic Beads HEK293
Danio rerio (Zebrafish) (Brachydanio rerio) RFL19353DF Recombinant Full Length Danio Rerio Insulin-Induced Gene 1 Protein(Insig1) Protein, His-Tagged E.coli expression system His Full Length (1-251)
Gallus gallus (Chicken) RFL18028GF Recombinant Full Length Chicken Insulin-Induced Gene 1 Protein(Insig1) Protein, His-Tagged E.coli expression system His Full Length (1-252)
Homo sapiens (Human) RFL34042HF Recombinant Full Length Human Insulin-Induced Gene 1 Protein(Insig1) Protein, His-Tagged E.coli expression system His Full Length (1-277)
Mus musculus (Mouse) RFL12905MF Recombinant Full Length Mouse Insulin-Induced Gene 1 Protein(Insig1) Protein, His-Tagged E.coli expression system His Full Length (1-259)
Xenopus laevis (African clawed frog) RFL8821XF Recombinant Full Length Xenopus Laevis Insulin-Induced Gene 1 Protein(Insig1) Protein, His-Tagged E.coli expression system His Full Length (1-251)
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) RFL27359XF Recombinant Full Length Xenopus Tropicalis Insulin-Induced Gene 1 Protein(Insig1) Protein, His-Tagged E.coli expression system His Full Length (1-251)
Zebrafish INSIG1-10242Z Recombinant Zebrafish INSIG1 Mammalian Cell His
Chicken INSIG1-2654C Recombinant Chicken INSIG1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • INSIG1 Related Articles

INSIG1 involved in several pathways and played different roles in them. We selected most pathways INSIG1 participated on our site, such as Metabolism, Metabolism of lipids and lipoproteins, Regulation of cholesterol biosynthesis by SREBP (SREBF), which may be useful for your reference. Also, other proteins which involved in the same pathway with INSIG1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MetabolismCOX16;KCNB1;CYP17A1;ACAD11;DCT;DHODH;ARSE;MAPK1IP1L;BPNT1
Metabolism of lipids and lipoproteinsTIAM2;CYP8B2;ANKRD1;MED21;ACOT7;ARSI;APOC2;SLC27A5;ACOT2
Regulation of cholesterol biosynthesis by SREBP (SREBF)INSIG2;PMVK;YY2;NFYBB;INSIG1;DHCR7;MTF1;SREBF2;NFYBA
SREBP signallingRNF139;INSIG2;INSIG1;RBP4;DBI;SEC23B

INSIG1 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by INSIG1 itself. We selected most functions INSIG1 had, and list some proteins which have the same functions with INSIG1. You can find most of the proteins on our site.

Function Related Protein
protein bindingATF4;KLF5;ANGPTL4;UNG;BAHD1;CRCP;ANGPT1;TMEM173;PML

INSIG1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with INSIG1 here. Most of them are supplied by our site. Hope this information will be useful for your research of INSIG1.

SEC27; copa_schpo; CYP2C1; CYP2C2; COP1

Wang, WX; Wilfred, BR; et al. Individual microRNAs (miRNAs) display distinct mRNA targeting "rules". RNA BIOLOGY 7:373-380(2010).
  • Q&As
  • Reviews

Q&As (7)

Ask a question
How does INSIG1 contribute to cellular lipid droplet formation? 04/14/2022

INSIG1 contributes to cellular lipid droplet formation by influencing lipid homeostasis and storage in response to sterol levels.

Is INSIG1 involved in the regulation of triglyceride metabolism? 01/08/2022

While INSIG1 primarily regulates cholesterol synthesis, its indirect influence on triglyceride metabolism is observed through modulation of SREBP-regulated pathways.

How does INSIG1 impact the degradation of HMG-CoA reductase? 02/09/2020

INSIG1 promotes the degradation of HMG-CoA reductase, a key enzyme in cholesterol synthesis, through ubiquitination and proteasomal degradation.

Are there any known inhibitors or activators of INSIG1? 12/07/2018

There are no widely recognized small-molecule inhibitors or activators of INSIG1 identified to date.

What is the significance of INSIG1 in the feedback regulation of cholesterol synthesis? 03/28/2018

INSIG1 is crucial in the feedback regulation of cholesterol synthesis, preventing excess cholesterol production by inhibiting the activation of SREBP proteins.

Does INSIG1 expression respond to changes in cellular sterol levels? 08/08/2017

Yes, the expression of INSIG1 is responsive to changes in cellular sterol levels, serving as a key component of the sterol-sensing mechanism.

What is the role of INSIG1 in the unfolded protein response (UPR)? 02/26/2017

INSIG1 is involved in the unfolded protein response (UPR), a cellular stress response pathway associated with endoplasmic reticulum (ER) stress.

Customer Reviews (3)

Write a review
Reviews
07/19/2021

    We found the product's safety and biocompatibility reassuring, especially when handling sensitive samples.

    07/23/2018

      Precise immunoprecipitation results consistently reflected the product's quality.

      07/20/2017

        The product's innovative characteristics enabled us to delve into previously uncharted cellular mechanisms.

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