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F11R

  • Official Full Name

    F11 receptor

  • Overview

    Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple 5 alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established.
  • Synonyms

    F11R; F11 receptor; JAM1, junctional adhesion molecule 1; junctional adhesion molecule A; CD321; JAM 1; JAM A; JAMA; JCAM; PAM 1; platelet F11 receptor; platelet adhesion molecule 1; junctional adhesion molecule 1; JAM; KAT; JAM1; PAM-1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rhesus Macaque
  • Rhesus monkey
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Human Cell
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • Fc
  • hFc
  • His
  • GST
  • hIgG1
  • hIgG4
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human F11R-69H Recombinant Human F11R, Fc tagged HEK293 Fc Met 1-Ala 242
Human F11R-6785H Recombinant Human F11 Receptor, His-tagged E.coli His
Human F11R-788H Recombinant Human F11 Receptor, His-tagged Human Cell His
Human F11R-790H Recombinant Human F11R, His tagged Human Cell His
Human F11R-181H Recombinant Human F11R Protein HEK293 N/A Ser28-Val238
Human F11R-3604H Recombinant Human F11R Protein Wheat Germ N/A
Human F11R-3605H Recombinant Human F11R Protein, GST-tagged Wheat Germ GST
Human F11R-2741HCL Recombinant Human F11R cell lysate Human Cell N/A
Human F11R-6491H Recombinant Human F11R Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human F11R-961H Recombinant Human F11R Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human F11R-4480HF Recombinant Full Length Human F11R Protein, GST-tagged In Vitro Cell Free System GST 299 amino acids
Human F11R-301280H Recombinant Human F11R protein, GST-tagged E.coli GST Ser28-Ser162
Human F11R-1270H Recombinant Human F11R protein, His-tagged HEK293 His Ser28-Ala242
Human F11R-4478HF Recombinant Full Length Human F11R Protein In Vitro Cell Free System 314 amino acids
Human F11R-3548H Recombinant Human F11R Protein (Pro135-Arg228), C-Fc tagged Mammalian cells C-Fc Pro135-Arg228
Human F11R-2769H Recombinant Human F11R protein, His-tagged E.coli His 28-162 aa
Human F11R-3549H Recombinant Human F11R Protein (Pro135-Arg228), C-His tagged Mammalian cells C-His Pro135-Arg228
Human F11R-1343H Recombinant Human F11R Protein (Phe64-Leu249), N-His tagged E.coli N-His Phe64-Leu249
Human F11R-1044H Recombinant Human F11R protein(Gln24-Tyr213), hFc-tagged HEK293 C-hFc Gln24-Tyr213
Human F11R-1285H Recombinant Human F11R protein, hFc&His-tagged HEK293 hFc&His Ser28-Ala242
Human F11R-3547H Recombinant Human F11R Protein (Ser28-Val238), C-His tagged Mammalian cells C-His Ser28-Val238
Human F11R-4802H Recombinant Human F11R Protein (Met1-Val238), C-His tagged Mammalian cells C-His Met1-Val238
Mouse F11r-4032M Recombinant Mouse F11r protein(Met1-Ala242), hFc-tagged HEK293 C-hFc Met1-Ala242
Mouse F11r-1057M Recombinant Mouse F11r Protein, Fc Chimera Mammalian cells Fc
Mouse F11R-2127MCL Recombinant Mouse F11R cell lysate Human Cell N/A
Mouse F11r-44M Recombinant Mouse F11r Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse F11r-44M-B Recombinant Mouse F11r Protein Pre-coupled Magnetic Beads HEK293
Mouse F11r-2899M Recombinant Mouse F11r Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse F11r-1448M Recombinant Mouse F11r Protein, His-tagged E.coli N-His Lys27-Gly238
Rat F11R-2175R Recombinant Rat F11R Protein Mammalian Cell His
Rat F11r-7470R Recombinant Rat F11r protein, hFc-tagged HEK293 hFc Met1-Gly238
Rat F11r-8744R Recombinant Rat F11r protein(Met1-Gly238), His-tagged HEK293 C-His Met1-Gly238
Rat F11R-1437RCL Recombinant Rat F11R cell lysate Human Cell N/A
Rat F11r-1449R Recombinant Rat F11r Protein, His-tagged E.coli N-His Lys27-Gly238
Rat F11R-1832R Recombinant Rat F11R Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat F11R-1832R-B Recombinant Rat F11R Protein Pre-coupled Magnetic Beads HEK293
Rhesus monkey F11R-1731R Recombinant Rhesus Monkey F11R Protein HEK293 N/A
Rhesus monkey F11R-1732R Recombinant Rhesus Monkey F11R Protein, hIgG1-tagged HEK293 hIgG1
Rhesus monkey F11R-1733R Recombinant Rhesus Monkey F11R Protein, hIgG4-tagged HEK293 hIgG4
Mus musculus (Mouse) RFL6663MF Recombinant Full Length Mouse Junctional Adhesion Molecule A(F11R) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (27-300)
Rhesus Macaque F11R-1530R Recombinant Rhesus monkey F11R Protein, His-tagged Mammalian Cell His
Rhesus Macaque F11R-1355R-B Recombinant Rhesus Macaque F11R Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque F11R-1355R Recombinant Rhesus Macaque F11R Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken F11R-3682C Recombinant Chicken F11R Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • F11R Related Articles
  • F11R Related Research Area

F11R involved in several pathways and played different roles in them. We selected most pathways F11R participated on our site, such as Cell adhesion molecules (CAMs), Tight junction, Leukocyte transendothelial migration, which may be useful for your reference. Also, other proteins which involved in the same pathway with F11R were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cell adhesion molecules (CAMs)PTPRF;CLDNA;NLGN1;CLDND;PDCD1;PRPSAP2;LRRC4B;MPZL1L;NLGN4X
Tight junctionMYHC4;SMYHC1;YBX3;GNAI2;CLDN11;PRKCH;MYH7B;HRASA;CLDNB
Leukocyte transendothelial migrationARHGAP35;RAC1;PRKCB;VASP;ACTB;MYL12A;ITGAL;AASS;MLLT4
Epithelial cell signaling in Helicobacter pylori infectionATP6V1E2;IL-8;ATP6V1G2;MAP2K4;ATP6V1G3;MAPK9;IKBKB;PTPN11;MAPK12

F11R has several biochemical functions, for example, PDZ domain binding, protein binding, virus receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by F11R itself. We selected most functions F11R had, and list some proteins which have the same functions with F11R. You can find most of the proteins on our site.

Function Related Protein
PDZ domain bindingCIT;NLGN1;ARHGAP29;DLG3;FZD1;LLGL2;ATP2B3B;LNX1;SLC9A3
protein bindingTAGLN;SRI;ASIC1;PROM1;FAM32A;CBX5;CDC45;CHRNB2;SENP1
virus receptor activityRPSA;LAMP1;ITGAV;DPP4;SERPINB3;CR1;CR2;SLAMF1;EFNB2

F11R has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with F11R here. Most of them are supplied by our site. Hope this information will be useful for your research of F11R.

SGTA; PRKCZ; PARD3; BDNF; PEX19; CASK

Babinska, A; Clement, CC; et al. Development of New Antiatherosclerotic and Antithrombotic Drugs Utilizing F11 Receptor (F11R/JAM-A) Peptides. BIOPOLYMERS 102:322-334(2014).
Schmitt, MMN; Fraemohs, L; et al. Atherogenic mononuclear cell recruitment is facilitated by oxidized lipoprotein-induced endothelial junctional adhesion molecule-A redistribution. ATHEROSCLEROSIS 234:254-264(2014).
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