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KL

  • Official Full Name

    klotho

  • Overview

    This gene encodes a type-I membrane protein that is related to β-glucuronidases. Reduced production of this protein has been observed in patients with chronic renal failure (CRF), and this may be one of the factors underlying the degenerative processes (
  • Synonyms

    KL; klotho;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • CHO
  • E.coli
  • HEK293
  • Mammalian Cell
  • Mammalian cells
  • Fc
  • His
  • His (Fc)
  • Avi
  • His|GST
  • His|T7
  • N/A
  • N
  • SUMO
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human KL-388H Active Recombinant Human Klotho, His-tagged Mammalian cells His
Human KL-47H Recombinant Human KLOTHO, His-tagged CHO His
Human KL-29904TH Recombinant Human KL CHO N/A
Human KL-386H Recombinant Human KL, Fc-tagged HEK293 Fc
Human KL-2155H Recombinant Human Klotho, Extracellular Domain, Fc Chimera HEK293 Fc
Human KL-4936HCL Recombinant Human KL 293 Cell Lysate HEK293 N/A
Human KL-3220H-B Recombinant Human KL Protein Pre-coupled Magnetic Beads HEK293
Human KL-1071H Recombinant Human KL Protein, His&SUMO-tagged E.coli N-His&SUMO Phe765-Ser981
Human KL-3220H Recombinant Human KL Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human KL-3302H Recombinant Human KL Protein (Glu34-Ser981), N-His tagged E.coli N-His Glu34-Ser981
Mouse Kl-362M Active Recombinant Mouse klotho protein, His-tagged CHO His
Mouse KL-8667M Recombinant Mouse KL Protein Mammalian Cell His
Mouse KL-4828M-B Recombinant Mouse KL Protein Pre-coupled Magnetic Beads HEK293
Mouse Kl-1562M Recombinant Mouse Kl protein, His-tagged E.coli His Leu59~Phe508
Mouse KL-4828M Recombinant Mouse KL Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat KL-3266R Recombinant Rat KL Protein Mammalian Cell His
Rat KL-2922R Recombinant Rat KL Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat KL-2922R-B Recombinant Rat KL Protein Pre-coupled Magnetic Beads HEK293
Rat Kl-1563R Recombinant Rat Kl protein, His & GST-tagged E.coli His/GST Leu517~Leu956
Rat Kl-1749R Recombinant Rat Kl protein, His & T7-tagged E.coli His/T7 Leu517~Leu956 (Accession # Q9Z2Y9)
Rat Kl-1714R Recombinant Rat Kl Protein, His-tagged E.coli N-His Leu517-Leu956
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • KL Related Articles
  • KL Related Gene Family

KL involved in several pathways and played different roles in them. We selected most pathways KL participated on our site, such as Pentose and glucuronate interconversions, Starch and sucrose metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with KL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Pentose and glucuronate interconversionsAKR1B7;UGT2B15;UGT1AB;DHDH;UGT1A7C;ALDH2.1;UGT2A3;UGT2A2;CRYL1
Starch and sucrose metabolismKL;TREH;UGP2A;UGDH;UGT5G1;PYGL;UGT1A6B;UGT1A7;AMY2A
Metabolic pathwaysDPYS;ALG9;DUT;PIGL;FAM213B;ACAA1A;ATP5L;EPT1;MTM1
Endocrine and other factor-regulated calcium reabsorptionGNAQ;VDR;KLK1B22;ESR1;PLCB2;GNAS;KLK1B24;BDKRB2;ATP1B2

KL has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KL itself. We selected most functions KL had, and list some proteins which have the same functions with KL. You can find most of the proteins on our site.

Function Related Protein
protein bindingRXRA;MECOM;CCNB1IP1;FAM200A;TGFB1;MED9;ITGB3B;SDCCAG3;SPRY1

KL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KL here. Most of them are supplied by our site. Hope this information will be useful for your research of KL.

rnb

Lee, EK; Martinez, MCR; et al. FGF23: Mediator of poor prognosis in a sizeable subgroup of patients with castration-resistant prostate cancer presenting with severe hypophosphatemia?. MEDICAL HYPOTHESES 83:482-487(2014).
He, Y; Siebuhr, AS; et al. Type X collagen levels are elevated in serum from human osteoarthritis patients and associated with biomarkers of cartilage degradation and inflammation. BMC MUSCULOSKELETAL DISORDERS 15:-(2014).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
How does KL protein affect cognitive function? 04/08/2022

KL protein may have a neuroprotective role and is being studied for its potential in preserving cognitive function and preventing neurodegenerative diseases.

Are there any KL protein-based therapies available for clinical use? 04/07/2022

Currently, there are no FDA-approved KL protein-based therapies, but research in this area is ongoing.

Can KL protein supplementation slow down the aging process? 10/25/2021

While research suggests a connection between KL protein and aging, it is not yet clear if KL protein supplementation can effectively slow down the aging process in humans.

How is KL protein measured in clinical settings? 07/19/2018

KL protein levels can be measured in blood and urine samples using various laboratory techniques.

Are there any clinical trials exploring KL protein-based therapies? 04/28/2016

Yes, several clinical trials are investigating the potential therapeutic benefits of KL protein supplementation in kidney disease and other disorders.

Customer Reviews (3)

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Reviews
01/31/2021

    The KL protein's reliability and ease of use have made it an essential component of my structural investigations.

    01/22/2019

      Its ability to preserve structural integrity and facilitate high-resolution imaging has greatly enhanced my understanding of protein complexes and their interactions.

      07/22/2016

        Furthermore, the KL protein has demonstrated great utility in protein electron microscopy structure analysis.

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