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LDB3

Official Full Name

LIM domain binding 3
Overview

This gene encodes a PDZ domain-containing protein. PDZ motifs are modular protein-protein interaction domains consisting of 80-120 amino acid residues. PDZ domain-containing proteins interact with each other in cytoskeletal assembly or with other proteins involved in targeting and clustering of membrane proteins. The protein encoded by this gene interacts with alpha-actinin-2 through its N-terminal PDZ domain and with protein kinase C via its C-terminal LIM domains. The LIM domain is a cysteine-rich motif defined by 50-60 amino acids containing two zinc-binding modules. This protein also interacts with all three members of the myozenin family. Mutations in this gene have been associated with myofibrillar myopathy and dilated cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been identified; all isoforms have N-terminal PDZ domains while only longer isoforms (1, 2 and 5) have C-terminal LIM domains.
Synonyms

LDB3; LIM domain binding 3; LIM domain-binding protein 3; cypher; KIAA0613; oracle; PDLIM6; ZASP; CMD1C; HGNC:15710; KIAA01613; LDB3_HUMAN; LDB3Z1; LIM domain binding protein 3; LVNC3; PDZ and LIM domain 6; Protein cypher; Z band alternatively spliced PDZ motif; Z band alternatively spliced PDZ motif protein; Z-band alternatively spliced PDZ-motif protein; OTTHUMP00000020008; OTTHUMP00000020009; LDB3Z4;

Type

Cell & Tissue Lysates
Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse

Source

E.coli
HEK293
HEK293T
Mammalian Cell

Tag

GST
His
His (Fc)
Avi
Myc
DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	LDB3-977HCL	Recombinant Human LDB3 cell lysate		N/A		Inquiry
Human	LDB3-2154H	Recombinant Human LDB3 Protein (1-283 aa), GST-tagged	E.coli	GST	1-283 aa	Inquiry
Human	LDB3-1539H	Recombinant Human LDB3 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Mouse	LDB3-9019M	Recombinant Mouse LDB3 Protein	Mammalian Cell	His		Inquiry
Mouse	LDB3-5020M	Recombinant Mouse LDB3 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	Ldb3-3765M	Recombinant Mouse Ldb3 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Mouse	LDB3-5020M-B	Recombinant Mouse LDB3 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Chicken	LDB3-5478C	Recombinant Chicken LDB3	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

LDB3 involved in several pathways and played different roles in them. We selected most pathways LDB3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with LDB3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

LDB3 has several biochemical functions, for example, cytoskeletal protein binding, muscle alpha-actinin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LDB3 itself. We selected most functions LDB3 had, and list some proteins which have the same functions with LDB3. You can find most of the proteins on our site.

Function	Related Protein
cytoskeletal protein binding	ABI1;CDK5;RPH3AL;EPB41L3B;EPB41L4B;PACSIN1A;TNNT2A;LDB3;B4GALT1
muscle alpha-actinin binding	NRAP;TTN;PDLIM2;PKD2;PKD2L1;LDB3;MYPN;PALLD
protein binding	PPP4R4;AHI1;VPS16;HAAO;ORC3L;GPRASP2;CTNNAL1;SEPT10;GTPBP4
protein kinase C binding	TWF2;HDAC9;C1QBP;HDAC5;GLRX3;TIRAP;PARD3;SQSTM1;PICK1
zinc ion binding	CUL9;PIAS1;BIRC2;CPM;RNF214;FHL3B;ZNFL1;ZDHHC22;EHMT2

LDB3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LDB3 here. Most of them are supplied by our site. Hope this information will be useful for your research of LDB3.

ALB