LDHA
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Official Full Name
lactate dehydrogenase A
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Overview
The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. Mutations in this gene have been linked to exertional myoglobinuria. Multiple transcript variants encoding different isoforms have been found for this gene. The human genome contains several non-transcribed pseudogenes of this gene. [provided by RefSeq, Sep 2008] -
Synonyms
LDHA; lactate dehydrogenase A; LDH1; LDHM; GSD11; PIG19; HEL-S-133P; L-lactate dehydrogenase A chain; LDH-A; LDH-M; LDH muscle subunit; lactate dehydrogenase M; proliferation-inducing gene 19; renal carcinoma antigen NY-REN-59; cell proliferation-inducing gene 19 protein; epididymis secretory sperm binding protein Li 133P;
- Native Proteins
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Assay Kits
- Chicken
- Human
- Mouse
- Pig
- Rat
- Rhesus Macaque
- Staphylococcus Aureus
- Zebrafish
- Chicken
- E. coli
- E.coli
- HEK293
- HEK293T
- Human Erythrocyte
- Human Heart
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- C
- His
- Flag
- GST
- His (Fc)
- Avi
- His|GST
- His|SUMO
- MYC
- DDK
- Myc|DDK
- N/A
- N
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
- LDHA Related Articles
- LDHA Related Research Area
LDHA involved in several pathways and played different roles in them. We selected most pathways LDHA participated on our site, such as Glycolysis / Gluconeogenesis, Cysteine and methionine metabolism, Pyruvate metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with LDHA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glycolysis / Gluconeogenesis | G6PCA.1;LDHC;ALDH3B1;TPI1B;PFKMA;ENO2;PGAM1A;ALDH7A1;HK2 |
| Cysteine and methionine metabolism | DNMT3;MDH2;CBS;ADI1;CTH;SDS;MTR;GOT2A;MAT2B |
| Pyruvate metabolism | ACSS2L;FH;PDK3;ACACB;PDHB;LDHD;ALDH3A2A;FH1;LDHBA |
| Propanoate metabolism | MLYCD;LDHA;HADHAA;LDHAL6A;LDHAL6B;BCKDHB;SUCLG1;DLDH;PCCB |
| Metabolic pathways | ATP6V1D;ALDOC;PAFAH1B1A;HIBADHB;UGT2B15;NDUFA1;HYI;BCAT1;EXT1 |
| HIF- signaling pathway | ENO3;NOS2;INS2;IGF1;CAMK2G;TEK;TF;AKT2;PDHA2 |
| Central carbon metabolism in cancer | ERBB2;KIT;MAPK3;HRAS;PIK3R1;MAPK1;PIK3CG;SIRT3;RET |
LDHA has several biochemical functions, for example, L-lactate dehydrogenase activity, NAD binding, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LDHA itself. We selected most functions LDHA had, and list some proteins which have the same functions with LDHA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| L-lactate dehydrogenase activity | LDHB;LDHBB;LDHBA;LDHA;LDHAL6B;LDHAL6A;LDHC |
| NAD binding | HADHA;GRHPR;GPD1A;GRHPRA;LDHB;SORD;ME3;DLD;MDH1 |
| identical protein binding | PRDX1;STAT6;VCP;CDC42;USP4;ATL3;BNIP3;FRS3;EIF2AK3 |
| kinase binding | CEBPB;STX1A;CTNNB1;TRIP6;HPCA;PFKM;ATF5;TOLLIP;CEBPA |
| protein binding | BORA;RB1;ANLN;KLF11;RAD1;FGFRL1B;HIST1H4G;KRTAP10-4;CRX |
LDHA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LDHA here. Most of them are supplied by our site. Hope this information will be useful for your research of LDHA.
HSPA8; 1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate; 1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate; pyruvate; nadh; YWHAZ; TFAP2A; LDHB; TERF1; hpaX; dppC3; ydaJ; XRN1; metE
- Q&As
- Reviews
Q&As (5)
Ask a questionLDHA has been associated with studies of diseases such as breast, stomach and lung adenocarcinomas.
LDHA is mainly located in the cytoplasm.
LDHA inhibits the growth and invasion of gastric cancer cells and promotes apoptosis by inhibiting glycolysis.
LDHA expression levels are upregulated in breast cancer tissues.
LDHA binds directly to nicotine and is a target for nicotine.
Customer Reviews (3)
Write a reviewThe protein composition was stable and concentrated, allowing me to obtain satisfactory experimental results.
The LDHA proteins purchased from your company is suitable for ELISA.
The technician modified my experimental protocol so that my experiment went smoothly.
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