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LEP

  • Official Full Name

    leptin

  • Overview

    This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development.
  • Synonyms

    LEP; leptin; obesity factor; OB; obese; OBS;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Native Proteins
  • Transfected Stable Cell Lines
  • Protein Pre-coupled Magnetic Beads
  • Bovine
  • Cattle
  • Chicken
  • Dog
  • Equine
  • Horse
  • Human
  • Mouse
  • Murine
  • Ovine
  • Pig
  • Pufferfish
  • Rabbit
  • Rat
  • Rhesus Macaque
  • Rhesus monkey
  • Bacillus subtilis
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • Human
  • Human Cell
  • Mammalian Cell
  • Mouse
  • Ovine
  • His
  • His (Fc)
  • Avi
  • His|GST
  • His|S
  • His|T7
  • Myc
  • DDK
  • MYC
  • N/A
  • N
  • Strep II
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human LEP-260H Active Recombinant Human Leptin Antagonist Triple Mutant, PEG-tagged Human N/A
Human LEP-336H Active Recombinant Human Leptin E.coli N/A
Human LEP-81H Active Recombinant Human Leptin HEK293 N/A
Human LEP-1272H Acitve Recombinant Human LEP protein(Val22-Cys167) E. coli N/A Val22-Cys167
Human LEP-12H Recombinant Human Leptin, His Tag E.coli His
Human LEP-225H Recombinant Human LEP E.coli N/A
Human LEP-202H Recombinant Human LEP, None tagged E.coli N/A
Human LEP-277H Recombinant Human LEP, StrepII-tagged Human Cell Strep II 22-167, 146 a.a.
Human LEP-641H Recombinant Human LEP protein E.coli N/A 146
Human LEP-13H Recombinant Human Leptin, His-tagged E.coli His
Human LEP-3626H Recombinant Human Leptin E.coli N/A
Human LEP-189H Recombinant Human LEP protein E.coli N/A
Human LEP-675H Recombinant Human LEP protein, His & GST-tagged E.coli His/GST Val22~Cys167
Human LEP-4773HCL Recombinant Human LEP 293 Cell Lysate HEK293 N/A
Human LEP-27641TH Native Human LEP E.coli N/A
Human LEP-201H Active Recombinant Human LEP Protein E.coli
Human LEP-3523H Recombinant Human LEP Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human LEP-164H Recombinant Human Leptin Reference standard E.coli N/A
Human LEP-5232H Recombinant Human LEP protein, His-tagged E.coli His 29-164aa
Human LEP-01H Recombinant Human LEP Protein, Myc/DDK-tagged HEK293T Myc/DDK
Human LEP-0610H Recombinant Human LEP Protein (Val22-Cys167), Tag Free Bacillus subtilis Tag Free Val22-Cys167
Human LEP-4433H Recombinant Human LEP Protein (Val22-Cys167), N-His tagged E.coli N-His Val22-Cys167
Mouse Lep-261M Recombinant Mouse Leptin Antagonist Triple Mutant Mouse N/A
Mouse LEP-9048M Recombinant Mouse LEP Protein Mammalian Cell His
Mouse Lep-146M Recombinant Mouse Leptin, PEG E.coli N/A
Mouse Lep-226M Recombinant Mouse Lep E.coli N/A
Mouse Lep-18M Recombinant Mouse Leptin, Antagonist Triple Mutant E.coli N/A
Mouse Lep-17M Recombinant Mouse Lep Protein, His/S-tagged E.coli His/S
Mouse Lep-16M Recombinant Mouse Leptin E.coli N/A
Mouse Lep-6933M Recombinant Mouse Leptin E.coli N/A 1-250aa
Mouse LEP-5041M Recombinant Mouse LEP Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Lep-166M Recombinant Mouse Leptin Reference standard E.coli N/A
Mouse Lep-120M Active Recombinant Mouse Lep Protein E.coli
Mouse Lep-202M Active Recombinant Mouse Lep Protein E.coli
Mouse Lep-121M Recombinant Mouse Lep Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse LEP-3284M Recombinant Mouse LEP protein, His-tagged E.coli His Val22~Cys167
Mouse Lep-7253M Recombinant Mouse Lep Protein E.coli
Mouse LEP-5041M-B Recombinant Mouse LEP Protein Pre-coupled Magnetic Beads HEK293
Rat Lep-27R Active Recombinant Rat Leptin, Antagonist Triple Mutant E.coli N/A
Rat Lep-228R Recombinant Rat Lep E.coli N/A
Rat Lep-147R Recombinant Rat Leptin E.coli N/A
Rat LEP-3376R Recombinant Rat LEP Protein Mammalian Cell His
Rat Lep-28R Recombinant Rat Leptin, Antagonist Triple Mutant, Mono-PEG E.coli N/A
Rat Lep-676R Recombinant Rat Lep protein, His & T7-tagged E.coli His/T7 Val22~Cys167 (Accession # P50596)
Rat LEP-203R Active Recombinant Rat LEP Protein E.coli
Rat LEP-3032R-B Recombinant Rat LEP Protein Pre-coupled Magnetic Beads HEK293
Rat Lep-342L Active Recombinant Rat Lep Protein (147 aa) E.coli 147
Rat LEP-3032R Recombinant Rat LEP Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus monkey LEP-2725R Recombinant Rhesus monkey LEP Protein, His-tagged E.coli N-His Val22-Cys167
Rabbit Lep-338R Active Recombinant Rabbit Leptin E.coli N/A
Rabbit LEP-25R Recombinant Rabbit Leptin E.coli N/A
Rabbit LEP-1087R Recombinant Rabbit LEP Protein, His-tagged E.coli N-His Val22-Cys167
Dog LEP-09D Recombinant Dog Leptin E.coli N/A
Dog LEP-1085D Recombinant Dog LEP Protein, His-tagged E.coli N-His Val22-Cys167
Bovine LEP-06B Recombinant Bovine Leptin E.coli N/A
Cattle LEP-672C Recombinant Cattle LEP protein, His & T7-tagged E.coli His/T7 Asp29~Gln160 (Accession # P50595)
Equine LEP-10H Recombinant Horse Leptin E.coli N/A
Horse LEP-673H Recombinant Horse LEP protein, His & T7-tagged E.coli His/T7 Ile15~Ala141 (Accession # Q9TU09)
Horse LEP-1086H Recombinant Horse LEP Protein, His-tagged E.coli N-His Val13-Ser145
Murine Lep-337M Active Recombinant Murine Lep protein E.coli N/A 147 amino acid
Ovine LEP-264O Active Recombinant Ovine Leptin Antagonist Triple Mutant, PEG-tagged Ovine N/A
Ovine LEP-19O Recombinant Ovine Leptin E.coli N/A
Ovine LEP-22O Recombinant Ovine Leptin, MTS-tagged E.coli N/A
Ovine LEP-20O Recombinant Ovine Leptin, Antagonist Quadruple Mutant E.coli N/A
Ovine LEP-21O Recombinant Ovine Leptin, Antagonist Triple Mutant E.coli N/A
Pufferfish LEP-23P Recombinant Pufferfish Leptin E.coli N/A
Rhesus Macaque LEP-2496R Recombinant Rhesus monkey LEP Protein, His-tagged Mammalian Cell His
Rhesus Macaque LEP-2317R-B Recombinant Rhesus Macaque LEP Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque LEP-2317R Recombinant Rhesus Macaque LEP Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Pig LEP-24P Recombinant Porcine Leptin E.coli N/A
Pig LEP-1088P Recombinant Pig LEP Protein, His-tagged E.coli N-His Met1-Cys167
Chicken LEP-07C Recombinant Chicken Leptin E.coli N/A
Chicken LEP-08C Recombinant Chicken Leptin E.coli N/A
Chicken LEP-674C Recombinant Chicken LEP protein, His & S-tagged E.coli His/S Val19~Cys163 (Accession# O42164)
  • Involved Pathway
  • Protein Function
  • Interacting Protein

LEP involved in several pathways and played different roles in them. We selected most pathways LEP participated on our site, such as Cytokine-cytokine receptor interaction, Neuroactive ligand-receptor interaction, AMPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with LEP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionIL20RA;BMPR2;KITA;KITLGA;IL-15RA;LOC100033925;MPL;EPOR;IFNGR2
Neuroactive ligand-receptor interactionGRIN1;MC5RA;TAAR6;GHR;HTR2B;TAAR10A;DRD2L;PTGER4;LHBETA1
AMPK signaling pathwayINS2;PCK2;PIK3R3;RHEB;G6PC3;PPARG;CAMKK2;TBC1D1;EEF2K
Jak-STAT signaling pathwayPTPN2A;IFNAR1;IFNAR2;LEPA;STAT3;PIK3R3B;AKT1;IFNPHI3;IL2RGA
Adipocytokine signaling pathwayJAK2B;RXRA;NFKBIA;PRKAB2;PPARAB;SLC2A1;ADIPOR1B;PTPN11B;POMCA
Non-alcoholic fatty liver disease (NAFLD)ATF4;KCNA3;TGFB1;NDUFB2;NDUFA1;IKBKB;CASP8;PIK3CA;GSK3B

LEP has several biochemical functions, for example, growth factor activity, hormone activity, peptide hormone receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LEP itself. We selected most functions LEP had, and list some proteins which have the same functions with LEP. You can find most of the proteins on our site.

Function Related Protein
growth factor activityIL8L2;GDF9;IL6;FGF9;AGT;FGF1;AMBN;OSGIN1;IL7
hormone activityINSL5;AGT;GCG;PTH;RLN3A;IGF1;Gh;C1QTNF9;CSH1
peptide hormone receptor bindingJAK2;ADCYAP1;PTPN11;NPPC;NPPA;RUNDC3A;LEP;FYN;PTHLHA

LEP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LEP here. Most of them are supplied by our site. Hope this information will be useful for your research of LEP.

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