LGI1
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Official Full Name
leucine-rich, glioma inactivated 1
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Overview
This gene is rearranged as a result of translocations in glioblastoma cell lines. The protein contains a hydrophobic segment representing a putative transmembrane domain with the amino terminus located outside the cell. It also contains leucine-rich repeats with conserved cysteine-rich flanking sequences. This gene is predominantly expressed in neural tissues and its expression is reduced in low grade brain tumors and significantly reduced or absent in malignant gliomas. Mutations in this gene result in autosomal dominant lateral temporal epilepsy. [provided by RefSeq, Jul 2008] -
Synonyms
LGI1; leucine-rich, glioma inactivated 1; EPT; ETL1; ADLTE; ADPAEF; ADPEAF; IB1099; EPITEMPIN; leucine-rich glioma-inactivated protein 1; epitempin-1;
- Cell & Tissue Lysates
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Rhesus Macaque
- E.coli
- HEK293
- Mammalian Cell
- C
- His
- His (Fc)
- Avi
- Myc
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- LGI1 Related Articles
LGI1 involved in several pathways and played different roles in them. We selected most pathways LGI1 participated on our site, such as Developmental Biology, LGI-ADAM interactions, which may be useful for your reference. Also, other proteins which involved in the same pathway with LGI1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Developmental Biology | MED6;AP2M1;PAQR3B;HELZ2;CNTN1;EVL;UNC5D;MYF6;DPYSL5A |
| LGI-ADAM interactions | CACNG2B;CACNG8A;LGI1;LGI2B;LGI2;LGI2A;ADAM22;STX1B;ADAM23 |
LGI1 has several biochemical functions, for example, protein binding, receptor binding, NOT receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LGI1 itself. We selected most functions LGI1 had, and list some proteins which have the same functions with LGI1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | HOOK1;RSPH1;CISH;ZNF256;HSPG2;CDAN1;CCDC101;NPHS1;KCNH7 |
| receptor binding | ARPP19A;PECI;DDO;GNB2L1;IDH1;PTK2AB;ADIPOQ;ARRB2;HCK |
| NOT receptor binding | ITK;TEC;STYK1;LGI1;BMX;TXK;BTK |
LGI1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LGI1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LGI1.
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