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LIMA1

  • Official Full Name

    LIM domain and actin binding 1

  • Overview

    This gene encodes a cytoskeleton-associated protein that inhibits actin filament depolymerization and cross-links filaments in bundles. It is downregulated in some cancer cell lines. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and expression of some of the variants maybe independently regulated.
  • Synonyms

    LIMA1; LIM domain and actin binding 1; LIM domain and actin-binding protein 1; epithelial protein lost in neoplasm beta; EPLIN; 1110021C24Rik; sterol regulatory element binding protein 3; SREBP3; FLJ38853; MGC131726;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human LIMA1-584H Recombinant Human LIMA1, GST-tagged E.coli GST C-term-400aa
Human LIMA1-4020H Recombinant Human LIMA1 Protein, GST-tagged Wheat Germ GST
Human LIMA1-4742HCL Recombinant Human LIMA1 293 Cell Lysate HEK293 N/A
Human LIMA1-4691HF Recombinant Full Length Human LIMA1 Protein, GST-tagged In Vitro Cell Free System GST 598 amino acids
Zebrafish LIMA1-9194Z Recombinant Zebrafish LIMA1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • LIMA1 Related Articles

LIMA1 involved in several pathways and played different roles in them. We selected most pathways LIMA1 participated on our site, such as Stabilization and expansion of the E-cadherin adherens junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with LIMA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Stabilization and expansion of the E-cadherin adherens junctionMYO6;KIFC3;LIMA1;PLEKHA7;LPP

LIMA1 has several biochemical functions, for example, actin filament binding, actin monomer binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LIMA1 itself. We selected most functions LIMA1 had, and list some proteins which have the same functions with LIMA1. You can find most of the proteins on our site.

Function Related Protein
actin filament bindingSHROOM3;SHROOM1;CORO1A;MTSS1;TTN;FSCN2B;PICK1;SCIN;TRIOBP
actin monomer bindingPFN4;ABL2;MKL1;LIMA1;TMSB4X;MYL3;TMSB15B;COBL;ABL1
protein bindingSLC22A5;MBNL3;CTSL1;LEPR;SEMA4C;SAC3D1;TMPRSS2;NAT8B;NINJ1
zinc ion bindingMTA3;MT2;CA15A;LIMS1;TRIM45;TRIM59;PHC2B;MKRN4;GALT

LIMA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LIMA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LIMA1.

SVIL; YWHAZ; dAK1_1; PLEKHG3; b4e2v5_human; RPSA; midostaurin; DST; PICALM; SEC16A; ACTG1; PDLIM1; MYO1C; MYO1C; PIK3C2A; Flot1; ABLIM1; GAK

Ohoka, A; Kajita, M; et al. EPLIN is a crucial regulator for extrusion of RasV12-transformed cells. JOURNAL OF CELL SCIENCE 128:781-789(2015).
Nie, ZL; Du, MQ; et al. Conversion of the LIMA1 tumour suppressor into an oncogenic LMO-like protein by API2-MALT1 in MALT lymphoma. Nature Communications 6:-(2015).
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